AB108619

Anti-Glycophorin C/GPC 抗体 [EPR4115]

Anti-Glycophorin C/GPC antibody [EPR4115]

RabMAb
Recombinant
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(3 Publications)

Rabbit Recombinant Monoclonal Glycophorin C/GPC antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications.

別名を表示する

CD236, GLPC, GPC, GYPC, Glycophorin-C, Glycoconnectin, Glycophorin-D, Glycoprotein beta, PAS-2', Sialoglycoprotein D, GPD

1 Images

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Western blot - Anti-Glycophorin C/GPC antibody [EPR4115] (AB108619)

All lanes:

Western blot - Anti-Glycophorin C/GPC antibody [EPR4115] (ab108619) at 1/1000 dilution

Lane 1:

TF1 cell lysates at 10 µg

Lane 2:

K562 cell lysates at 10 µg

Predicted band size: 14 kDa

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Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR4115

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }

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製品の詳細

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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出荷温度及び保存条件

製品の状態

Liquid

精製度

Tissue culture supernatant

バッファー組成

pH: 7.2 - 7.4 Preservative: 0.05% Sodium azide Constituents: 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 9.85% Tris glycine, 0.1% BSA

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

-20°C

保管に関する情報

Stable for 12 months at -20°C

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Glycophorin C also known as GPC is a membrane glycoprotein with a molecular mass of approximately 32 kDa. GPC is recognized by other names such as Glycophorin A-like and it is a significant component of the erythrocyte membrane. Researchers frequently refer to glycophorin C by its common abbreviation GPC. GPC expression occurs specifically in red blood cells where it plays a role in maintaining the cell structure and integrity by forming part of the interface between the cell membrane and the cytoskeleton.

Biological function summary

Glycophorin C modulates red blood cell characteristics by interacting with band 4.1 protein complex. The protein participates in the regulation of cell shape and mechanical flexibility which are important for the red blood cells to flow through capillaries effectively. This process involves interactions with spectrin and actin within the cytoskeleton underpinning the cellular architecture. The protein's function as an anchor for the band 4.1 complex links it with other glycophorins such as Glycophorin A.

Pathways

GPC integrates into erythrocyte membrane-associated pathways supporting membrane stability. It is key to the cytoskeleton-membrane linkage pathway where it interacts with proteins like spectrin and actin. Aimed at preserving the biconcave shape of erythrocytes these interactions enhance membrane elasticity and durability ensuring proper red blood cell function in the circulation. Additionally its association with the protein Rh-linked ankyrin connects GPC with pathways involving erythrocyte ion transport processes.

GPC plays a notable role in elliptocytosis and malaria. Elliptocytosis arises from mutations affecting GPC and other erythrocyte proteins such as band 4.1 leading to elongated and dysfunctional erythrocytes. Individuals with altered GPC expression show increased susceptibility or resistance to malaria caused by the Plasmodium parasite’s interaction with erythrocyte membrane proteins. Glycophorin C therefore remains an important focus of study for understanding the molecular basis of these conditions and designing therapeutic interventions.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

This protein is a minor sialoglycoprotein in human erythrocyte membranes. The blood group Gerbich antigens and receptors for Plasmodium falciparum merozoites are most likely located within the extracellular domain. Glycophorin-C plays an important role in regulating the stability of red cells.

See full target information GYPC

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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 13:6801 PubMed36357417

2022

Wireless theranostic smart contact lens for monitoring and control of intraocular pressure in glaucoma.

Applications

Unspecified application

Species

Unspecified reactive species

Tae Yeon Kim,Jee Won Mok,Sang Hoon Hong,Sang Hoon Jeong,Hyunsik Choi,Sangbaie Shin,Choun-Ki Joo,Sei Kwang Hahn

Journal of translational medicine 18:313 PubMed32795291

2020

Identification and validation of smoking-related genes in lung adenocarcinoma using an in vitro carcinogenesis model and bioinformatics analysis.

Applications

Unspecified application

Species

Unspecified reactive species

Jin Wang,Tao Chen,Xiaofan Yu,Nan OUYang,Lirong Tan,Beibei Jia,Jian Tong,Jianxiang Li

British journal of haematology 168:429-42 PubMed25283956

2014

Novel antibodies directed against the human erythropoietin receptor: creating a basis for clinical implementation.

Applications

Unspecified application

Species

Unspecified reactive species

Perry Maxwell,Florinda Melendez-Rodríguez,Kyle B Matchett,Julian Aragones,Nathalie Ben-Califa,Heidelinde Jaekel,Ludger Hengst,Herbert Lindner,Andre Bernardini,Ulf Brockmeier,Joachim Fandrey,Fritz Grunert,Howard S Oster,Moshe Mittelman,Mohamed El-Tanani,Markus Thiersch,Edith M Schneider Gasser,Max Gassmann,David Dangoor,Robert J Cuthbert,Alexandra Irvine,Anne Jordan,Terence Lappin,John Thompson,Drorit Neumann

View all publications

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