Anti-Glutamine Synthetase 抗体 (ab49873)
Key features and details
- Rabbit polyclonal to Glutamine Synthetase
- Suitable for: WB
- Reacts with: Rat
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-Glutamine Synthetase antibody
Glutamine Synthetase 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Glutamine Synthetase -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Rat
交差が予測される動物種: Chicken, Hamster, Cow, Dog, Human, Pig, Cynomolgus monkey
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免疫原
Synthetic peptide corresponding to Mouse Glutamine Synthetase aa 350-450 (C terminal).
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ポジティブ･コントロール
- WB: Rat brain whole extract.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
pH: 7.40
Preservative: 0.097% Sodium azide
Constituent: 0.0268% PBS -
Concentration information loading... -
精製度
Ion Exchange Chromatography -
特記事項（精製）
Whole antiserum is fractionated and then further purified by ion-exchange chromatography to provide the IgG fraction of antiserum that is essentially free of other rabbit serum proteins. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab49873の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
1/10000. Predicted molecular weight: 42 kDa.
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| 特記事項 |
|---|
|
WB
1/10000. Predicted molecular weight: 42 kDa. |
ターゲット情報
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機能
This enzyme has 2 functions: it catalyzes the production of glutamine and 4-aminobutanoate (gamma-aminobutyric acid, GABA), the latter in a pyridoxal phosphate-independent manner (By similarity). Essential for proliferation of fetal skin fibroblasts. -
関連疾患
Defects in GLUL are the cause of congenital systemic glutamine deficiency (CSGD) [MIM:610015]. CSGD is a rare developmental disorder with severe brain malformation resulting in multi-organ failure and neonatal death. Glutamine is largely absent from affected patients serum, urine and cerebrospinal fluid. -
配列類似性
Belongs to the glutamine synthetase family. -
発生段階
Expressed during early fetal stages. -
細胞内局在
Cytoplasm. Mitochondrion. - Information by UniProt
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参照データベース
- Entrez Gene: 396489 Chicken
- Entrez Gene: 281199 Cow
- Entrez Gene: 2752 Human
- Entrez Gene: 396944 Pig
- Entrez Gene: 24957 Rat
- Omim: 138290 Human
- SwissProt: P16580 Chicken
- SwissProt: P15103 Cow
see all -
別名
- cell proliferation-inducing protein 59 antibody
- Cgl2214 antibody
- GLNA antibody
see all
画像
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Western blot - Anti-Glutamine Synthetase antibody (ab49873)Lane 1 : Anti-Glutamine Synthetase antibody (ab49873) at 1/5000 dilution
Lane 2 : Anti-Glutamine Synthetase antibody (ab49873) at 1/10000 dilution
Lane 3 : Anti-Glutamine Synthetase antibody (ab49873) at 1/20000 dilution
All lanes : Rat brain whole extract
Secondary
All lanes : Goat Anti-Rabbit IgG-Peroxidase
Predicted band size: 42 kDa
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (75)
ab49873 は 75 報の論文で使用されています。
- Guo PC et al. Cell atlas of CCl 4-induced progressive liver fibrosis reveals stage-specific responses. Zool Res 44:451-466 (2023). PubMed: 36994536
- Pu W et al. Bipotent transitional liver progenitor cells contribute to liver regeneration. Nat Genet 55:651-664 (2023). PubMed: 36914834
- Liu X et al. Functional ProTracer identifies patterns of cell proliferation in tissues and underlying regulatory mechanisms. NPJ Regen Med 8:41 (2023). PubMed: 37537178
- Hoehme S et al. Digital twin demonstrates significance of biomechanical growth control in liver regeneration after partial hepatectomy. iScience 26:105714 (2023). PubMed: 36691615
- Xie Z et al. Resveratrol Alleviates Retinal Ischemia-Reperfusion Injury by Inhibiting the NLRP3/Gasdermin D/Caspase-1/Interleukin-1β Pyroptosis Pathway. Invest Ophthalmol Vis Sci 64:28 (2023). PubMed: 38133508