Anti-Glutamate Transporter 1 抗体 (ab106289)
Key features and details
- Rabbit polyclonal to Glutamate Transporter 1
- Suitable for: WB
- Reacts with: Mouse, Rat
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-Glutamate Transporter 1 antibody -
製品の詳細
Rabbit polyclonal to Glutamate Transporter 1 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Mouse, Rat
交差が予測される動物種: Human
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免疫原
Synthetic peptide corresponding to Rat Glutamate Transporter 1 (C terminal). A 16 residue synthetic peptide derived from the C terminal domain of Rat glutamate transporter 1.
Database link: P31596 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Avoid freeze / thaw cycle. -
バッファー
Constituent: Whole serum -
Concentration information loading... -
精製度
Whole antiserum -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab106289の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
1/200 - 1/5000. Predicted molecular weight: 62 kDa.
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| 特記事項 |
|---|
|
WB
1/200 - 1/5000. Predicted molecular weight: 62 kDa. |
ターゲット情報
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機能
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium. -
配列類似性
Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family. SLC1A2 subfamily. -
翻訳後修飾
Glycosylated.
Palmitoylation at Cys-38 is not required for correct subcellular localization, but is important for glutamate uptake activity. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 6506 Human
- Entrez Gene: 20511 Mouse
- Entrez Gene: 29482 Rat
- Omim: 600300 Human
- SwissProt: P43004 Human
- SwissProt: P43006 Mouse
- SwissProt: P31596 Rat
- Unigene: 502338 Human
see all -
別名
- EAA2_HUMAN antibody
- EAAT2 antibody
- Excitatory amino acid transporter 2 antibody
see all
画像
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Western blot - Anti-Glutamate Transporter 1 antibody (ab106289)All lanes : Anti-Glutamate Transporter 1 antibody (ab106289) at 1/1000 dilution
Lane 1 : Protein extract from rat brain
Lane 2 : Protein extract from mouse brain
Predicted band size: 62 kDa
Lane 3 shows inhibition of the immunoreactivity of ab106289 with blocking peptide.
Glutamate Transporter 1 protein is detected at 35 kDa and 70 kDa as a dimer.
データシートおよび資料
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Datasheet download
参考文献 (11)
ab106289 は 11 報の論文で使用されています。
- Postnikova TY et al. Delayed Impairment of Hippocampal Synaptic Plasticity after Pentylenetetrazole-Induced Seizures in Young Rats. Int J Mol Sci 23:N/A (2022). PubMed: 36362260
- Sanches E et al. Dose-Dependent Neuroprotective Effects of Bovine Lactoferrin Following Neonatal Hypoxia-Ischemia in the Immature Rat Brain. Nutrients 13:N/A (2021). PubMed: 34836132
- Yan M et al. Ginkgo biloba extract protects diabetic rats against cerebral ischemia-reperfusion injury by suppressing oxidative stress and upregulating the expression of glutamate transporter 1. Mol Med Rep 21:1809-1818 (2020). PubMed: 32319622
- Lu Y et al. Neuron-Derived Estrogen Is Critical for Astrocyte Activation and Neuroprotection of the Ischemic Brain. J Neurosci 40:7355-7374 (2020). PubMed: 32817249
- Wang J et al. Astrocyte-Derived Estrogen Regulates Reactive Astrogliosis and is Neuroprotective following Ischemic Brain Injury. J Neurosci 40:9751-9771 (2020). PubMed: 33158962
