JavaScript is disabled in your browser. Please enable JavaScript to view this website.
AB217337

Anti-Glutamate receptor 3/GluA3 抗体

Anti-Glutamate receptor 3/GluA3 antibody

Be the first to review this product! Submit a review

|

(1 Publication)

Rabbit Polyclonal Glutamate receptor 3/GluA3 antibody. Suitable for IHC-P and reacts with Rat samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human GRIA3 aa 400 to C-terminus conjugated to Keyhole Limpet Haemocyanin.

別名を表示する

GluA3, GLUR3, GLURC, GRIA3, Glutamate receptor 3, GluR-3, AMPA-selective glutamate receptor 3, GluR-C, GluR-K3

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glutamate receptor 3/GluA3 antibody (AB217337)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glutamate receptor 3/GluA3 antibody (AB217337)

Immunohistochemical analysis of formalin-fixed, paraffin-embedded rat brain tissue labeling Glutamate receptor 3/GluA3 with ab217337 at 1/200 dilution followed by conjugation to the secondary antibody and DAB staining.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Rat

アプリケーション

IHC-P

applications

免疫原

Synthetic Peptide within Human GRIA3 aa 400 to C-terminus conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P42263

style
left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/500", "IHCP-species-notes": "<p></p>" } } }
style
left-column
style
left-column

出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Preservative: 0.02% Proclin 300 Constituents: 50% Glycerol (glycerin, glycerine), 48.98% TBS, 1X, 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
style
left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Glutamate receptor 3 also known as GluA3 or GRIA3 is an ionotropic receptor that mediates fast excitatory synaptic transmission in the central nervous system. It is part of the AMPA receptor family and has a molecular mass of approximately 100 kDa. This receptor predominantly localizes in the brain where it plays a significant role in the mediation of glutamate neurotransmission influencing synaptic plasticity and communication among neurons. Its expression is vital for transmitting signals across excitatory synapses affecting learning and memory processes.
Biological function summary

GluA3 operates as a subunit of AMPA receptors forming tetrameric complexes that facilitate synaptic signal transmission. These channels permit the influx of sodium and to a lesser extent calcium ions when activated by the neurotransmitter glutamate. The interaction of GluA3 with auxiliary proteins like transmembrane AMPA receptor regulatory proteins (TARPs) can modulate its function and trafficking. As an essential component of synaptic transmission GluA3 influences synaptic strength and is involved in various neuronal activities.

Pathways

GluA3 plays an important role in synaptic plasticity and long-term potentiation (LTP). Two important pathways associated with GluA3 are the mitogen-activated protein kinase (MAPK) pathway and the calcium/calmodulin-dependent protein kinase II (CaMKII) pathway. The regulation of these pathways through GluA3 modulation affects synaptic efficacy and memory formation. GluA3 interacts with proteins like PSD-95 which influences receptor assembly and synapse structure integrating into broader signaling networks that govern cellular responses and adaptations.

GluA3 has been linked to neurodegenerative diseases and psychiatric disorders. Alterations in GluA3 expression or function are associated with Alzheimer's disease where disrupted glutamatergic signaling contributes to cognitive decline. Additionally GluA3 plays a role in schizophrenia where AMPA receptor dysfunction affects neural circuitry and synaptic plasticity. In these contexts GluA3 often interacts with proteins like NMDA receptors where their combined dysfunction can lead to imbalances in excitatory-inhibitory signaling exacerbating disease symptoms.
style
left-column
style
left-column

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
style
left-column

ターゲットの情報

Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid (By similarity). L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission by inducing long-term potentiation (By similarity). Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of calcium (PubMed : 17989220). The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed : 17989220). In the presence of CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate (PubMed : 21172611).
See full target information GRIA3
style
left-column

文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in oncology 15:1645671 PubMed40919158

2025

Role of Meox1 in promoting lung tumor vascularization and impairing CD8 T cell mediated immunity.

Applications

Unspecified application

Species

Unspecified reactive species

Dacheng Yang,Qian Li,Zisheng Chen,Wei Kevin Zhang
View all publications
style
left-column
style
left-column
style
right-column

代替製品

Primary Antibodies

AB40845

Anti-Glutamate receptor 3/GluA3 antibody [EP813Y]

RabMAb|Recombinant

Western blot - Anti-Glutamate receptor 3/GluA3 antibody [EP813Y] (AB40845)

  • 0
  • 0
Primary Antibodies

AB232430

Anti-Glutamate receptor 3/GluA3 antibody [EP813Y] - BSA and Azide free

RabMAb|Recombinant

Western blot - Anti-Glutamate receptor 3/GluA3 antibody [EP813Y] - BSA and Azide free (AB232430)

  • 0
  • 0

組合せ製品

Primary Antibodies

AB206293

Anti-Ionotropic Glutamate receptor 2 + 3 antibody [EPR18115]

RabMAb|Recombinant|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ionotropic Glutamate receptor 2 + 3 antibody [EPR18115] (AB206293)

  • 5
  • 5
Primary Antibodies

AB109450

Anti-Glutamate Receptor 1 (AMPA subtype) antibody [EPR5479]

20ul selling size|RabMAb|Recombinant

Immunoprecipitation - Anti-Glutamate Receptor 1 (AMPA subtype) antibody [EPR5479] (AB109450)

  • 5
  • 2
Primary Antibodies

AB109182

Anti-NMDAR1 antibody [EPR2481(2)] - Neuronal Marker

20ul selling size|KO Validated|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-NMDAR1 antibody [EPR2481(2)] - Neuronal Marker (AB109182)

  • 4
  • 4
Primary Antibodies

AB150387

Anti-Metabotropic Glutamate Receptor 2 + 3 / MGLUR2 + MGLUR3 antibody [EPR8975]

20ul selling size|BOND RX™ Validated|RabMAb|Recombinant

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Metabotropic Glutamate Receptor 2 + 3 / MGLUR2 + MGLUR3 antibody [EPR8975] (AB150387)

  • 5
  • 2

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。
保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com