Anti-Glucose Transporter GLUT2 抗体 (ab111117)
Key features and details
- Goat polyclonal to Glucose Transporter GLUT2
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-Glucose Transporter GLUT2 antibody
Glucose Transporter GLUT2 一次抗体 製品一覧 -
製品の詳細
Goat polyclonal to Glucose Transporter GLUT2 -
由来種
Goat -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human
交差が予測される動物種: Rat, Cow
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免疫原
Synthetic peptide corresponding to Human Glucose Transporter GLUT2 aa 250-350 (internal sequence) conjugated to keyhole limpet haemocyanin (Cysteine residue).
Database link: P11168 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: Tris buffered saline, 0.5% BSA -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab111117の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-P | (2) |
Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
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| 特記事項 |
|---|
|
IHC-P
Use a concentration of 2.5 µg/ml. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol. |
ターゲット情報
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機能
Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. -
組織特異性
Liver, insulin-producing beta cell, small intestine and kidney. -
関連疾患
Fanconi-Bickel syndrome -
配列類似性
Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily. -
翻訳後修飾
N-glycosylated; required for stability and retention at the cell surface of pancreatic beta cells. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 6514 Human
- Entrez Gene: 25351 Rat
- Omim: 138160 Human
- SwissProt: P11168 Human
- SwissProt: P12336 Rat
- Unigene: 167584 Human
- Unigene: 89295 Rat
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別名
- liver antibody
- Glucose Transporter 2 antibody
- Glucose Transporter GLUT2 antibody
see all
画像
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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glucose Transporter GLUT2 antibody (ab111117)ab111117, at 2.5µg/ml, staining Glucose Transporter GLUT2 in formalin-fixed, paraffin-embedded Human Liver tissue by Immunohistochemistry.
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (9)
ab111117 は 9 報の論文で使用されています。
- Oppenländer L et al. Vertical sleeve gastrectomy triggers fast β-cell recovery upon overt diabetes. Mol Metab 54:101330 (2021). PubMed: 34500108
- Blanco AM et al. FGF21 Mimics a Fasting-Induced Metabolic State and Increases Appetite in Zebrafish. Sci Rep 10:6993 (2020). PubMed: 32332781
- Blanco AM et al. Feeding and food availability modulate brain-derived neurotrophic factor, an orexigen with metabolic roles in zebrafish. Sci Rep 10:10727 (2020). PubMed: 32612127
- Blanco AM et al. Goldfish adipocytes are pancreatic beta cell-like, glucose-responsive insulin-producing cells. J Cell Physiol 235:6875-6886 (2020). PubMed: 31989646
- Farnsworth NL et al. Exendin-4 overcomes cytokine-induced decreases in gap junction coupling via protein kinase A and Epac2 in mouse and human islets. J Physiol 597:431-447 (2019). PubMed: 30412665
- Giatromanolaki A et al. Programmed death-1 receptor (PD-1) and PD-ligand-1 (PD-L1) expression in non-small cell lung cancer and the immune-suppressive effect of anaerobic glycolysis. Med Oncol 36:76 (2019). PubMed: 31342270
- Merigo F et al. Glucose transporter expression in the human colon. World J Gastroenterol 24:775-793 (2018). PubMed: 29467549
- Blanco AM et al. Ghrelin Facilitates GLUT2-, SGLT1- and SGLT2-mediated Intestinal Glucose Transport in Goldfish (Carassius auratus). Sci Rep 7:45024 (2017). PubMed: 28338019
- Kahraman S et al. Diabetes-resistant NOR mice are more severely affected by streptozotocin compared to the diabetes-prone NOD mice: correlations with liver and kidney GLUT2 expressions. J Diabetes Res 2015:450128 (2015). IF . PubMed: 25699277