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AB10988

Anti-Glucagon 抗体 [K79bB10]

Anti-Glucagon antibody [K79bB10]

5

(13 Reviews)

|

(190 Publications)

Anti-Glucagon antibody [K79bB10] (ab10988) is a mouse monoclonal antibody detecting Glucagon in IHC-P. Suitable for Rat.

- Over 180 publications
- Trusted since 2004

別名を表示する

Pro-glucagon, GCG

2 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glucagon antibody [K79bB10] (AB10988)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glucagon antibody [K79bB10] (AB10988)

Formali-fixed, paraffin-embedded rat pancreas tissue stained for Glucagon using ab10988 at 10 μg/ml in immunohistochemical analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glucagon antibody [K79bB10] (AB10988)
  • IHC-P

AbReview25115****

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Glucagon antibody [K79bB10] (AB10988)

ab10988 staining Glucagon in rat pancreatic tissue by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections).

Tissue was fixed in paraformaldehyde, blocked with 2% serum for 1 hour at 25°C, then incubated with ab10988 at a 1/200 dilution for 1 hour at 25°C. The secondary used was a donkey anti-mouse IgG (H+L) conjugated to Texas Red, used at a 1/250 dilution. Nuclei counterstained with DAPI, green is staining for insulin.

Image courtesy of Thomas Schoeppe by Abreview.

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

K79bB10

アイソタイプ

IgG1

キャリアフリー

No

交差種

Rat

アプリケーション

IHC-P

applications

免疫原

Full Length Protein corresponding to Pig GCG. The exact immunogen used to generate this antibody is proprietary information.

P01274

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Cat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Common marmoset": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Dog": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Guinea pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Syrian hamster": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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製品の詳細

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Proprietary technique
精製に関する特記事項
Purified from Tissue culture supernatant.
バッファー組成
pH: 7.4 Preservative: 0.097% Sodium azide Constituents: PBS
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Glucagon also known as the “hunger hormone" is a 29-amino acid peptide hormone with a mass of approximately 3.5 kDa. It plays an important role in glucose metabolism and regulation of blood sugar levels. The human pancreas specifically the alpha cells located in the islets of Langerhans synthesizes and secretes glucagon. This hormone binds to glucagon receptors which are widely expressed across tissues including the liver and kidney where it initiates a cascade of signaling events.
Biological function summary

Glucagon plays a central role in maintaining glucose homeostasis. It increases blood glucose by promoting gluconeogenesis and glycogenolysis in the liver. Though glucagon mainly acts independently it exhibits significant interactions with other metabolic hormones such as insulin. This interaction helps balance blood sugar levels as glucagon and insulin work in opposition to ensure optimal blood glucose regulation.

Pathways

Glucagon primarily impacts the cAMP signaling pathway significantly increasing intracellular cAMP levels. This pathway initiates a complex series of downstream events including increased enzyme activity for gluconeogenesis and glycogen breakdown in the liver. Glucagon also cross-talks with insulin signaling pathways enabling the intertwined regulation of metabolism through these hormones and maintaining glucose balance.

Glucagon is closely linked to diabetes and hyperglycemia. Individuals with diabetes often exhibit dysregulated glucagon secretion leading to unstable blood sugar levels. Glucagon interacts with insulin in the pathology of diabetes where an improper balance between these hormones can exacerbate the disease. The understanding of glucagon's role in these conditions makes it a target for new therapeutic strategies including recombinant glucagon treatments and assays.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Glucagon. Plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes.. Glucagon-like peptide 1. Potent stimulator of glucose-dependent insulin release. Also stimulates insulin release in response to IL6. Plays important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Has growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis.. Glucagon-like peptide 2. Stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. The gastrointestinal tract, from the stomach to the colon is the principal target for GLP-2 action. Plays a key role in nutrient homeostasis, enhancing nutrient assimilation through enhanced gastrointestinal function, as well as increasing nutrient disposal. Stimulates intestinal glucose transport and decreases mucosal permeability.. Oxyntomodulin. Significantly reduces food intake. Inhibits gastric emptying in humans. Suppression of gastric emptying may lead to increased gastric distension, which may contribute to satiety by causing a sensation of fullness.. Glicentin. May modulate gastric acid secretion and the gastro-pyloro-duodenal activity. May play an important role in intestinal mucosal growth in the early period of life.
See full target information GCG

追加のターゲット

Glucagon
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文献 (190)

Recent publications for all applications. Explore the full list and refine your search

Nature 624:621-629 PubMed38049589

2023

Genetic risk converges on regulatory networks mediating early type 2 diabetes.

Applications

IHC-P, mIHC

Species

Human, Human

John T Walker,Diane C Saunders,Vivek Rai,Hung-Hsin Chen,Peter Orchard,Chunhua Dai,Yasminye D Pettway,Alexander L Hopkirk,Conrad V Reihsmann,Yicheng Tao,Simin Fan,Shristi Shrestha,Arushi Varshney,Lauren E Petty,Jordan J Wright,Christa Ventresca,Samir Agarwala,Radhika Aramandla,Greg Poffenberger,Regina Jenkins,Shaojun Mei,Nathaniel J Hart,Sharon Phillips,Hakmook Kang,Dale L Greiner,Leonard D Shultz,Rita Bottino,Jie Liu,Jennifer E Below,Stephen C J Parker,Alvin C Powers,Marcela Brissova

Frontiers in neuroscience 17:1179276 PubMed37397461

2023

The effects of targeted vagus nerve stimulation on glucose homeostasis in STZ-induced diabetic rodents.

Applications

Unspecified application

Species

Unspecified reactive species

Elliott W Dirr,Yogi Patel,Richard D Johnson,Kevin J Otto

Nature communications 14:3395 PubMed37296117

2023

Transparent tissue in solid state for solvent-free and antifade 3D imaging.

Applications

Unspecified application

Species

Unspecified reactive species

Fu-Ting Hsiao,Hung-Jen Chien,Ya-Hsien Chou,Shih-Jung Peng,Mei-Hsin Chung,Tzu-Hui Huang,Li-Wen Lo,Chia-Ning Shen,Hsiu-Pi Chang,Chih-Yuan Lee,Chien-Chia Chen,Yung-Ming Jeng,Yu-Wen Tien,Shiue-Cheng Tang

Frontiers in endocrinology 14:1161085 PubMed37223028

2023

Role of Delta/Notch-like EGF-related receptor in blood glucose homeostasis.

Applications

Unspecified application

Species

Unspecified reactive species

Nelmari Ruiz-Otero,Rejji Kuruvilla

Journal of diabetes 15:409-418 PubMed36942376

2023

β-Cell glucokinase expression was increased in type 2 diabetes subjects with better glycemic control.

Applications

Unspecified application

Species

Unspecified reactive species

Jingwen Liu,Hui Fu,Fuyun Kang,Guang Ning,Qicheng Ni,Weiqing Wang,Qidi Wang

Nature communications 14:1020 PubMed36823211

2023

THADA inhibition in mice protects against type 2 diabetes mellitus by improving pancreatic β-cell function and preserving β-cell mass.

Applications

Unspecified application

Species

Unspecified reactive species

Yuqing Zhang,Shan Han,Congcong Liu,Yuanwen Zheng,Hao Li,Fei Gao,Yuehong Bian,Xin Liu,Hongbin Liu,Shourui Hu,Yuxuan Li,Zi-Jiang Chen,Shigang Zhao,Han Zhao

Nature communications 14:600 PubMed36737436

2023

Cryo-EM structure supports a role of AQP7 as a junction protein.

Applications

Unspecified application

Species

Unspecified reactive species

Peng Huang,Raminta Venskutonytė,Rashmi B Prasad,Hamidreza Ardalani,Sofia W de Maré,Xiao Fan,Ping Li,Peter Spégel,Nieng Yan,Pontus Gourdon,Isabella Artner,Karin Lindkvist-Petersson

Nature communications 14:235 PubMed36646689

2023

Hyperaminoacidemia induces pancreatic α cell proliferation via synergism between the mTORC1 and CaSR-Gq signaling pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Yulong Gong,Bingyuan Yang,Dingdong Zhang,Yue Zhang,Zihan Tang,Liu Yang,Katie C Coate,Linlin Yin,Brittney A Covington,Ravi S Patel,Walter A Siv,Katelyn Sellick,Matthew Shou,Wenhan Chang,E Danielle Dean,Alvin C Powers,Wenbiao Chen

Molecular metabolism 67:101659 PubMed36529318

2022

Inhibition of stearoyl-CoA desaturase 1 in the mouse impairs pancreatic islet morphogenesis and promotes loss of β-cell identity and α-cell expansion in the mature pancreas.

Applications

Unspecified application

Species

Unspecified reactive species

Aneta M Dobosz,Justyna Janikiewicz,Ewelina Krogulec,Anna Dziewulska,Anna Ajduk,Marcin Szpila,Hanna Nieznańska,Andrzej A Szczepankiewicz,Dorota Wypych,Agnieszka Dobrzyn

EBioMedicine 87:104379 PubMed36463755

2022

A discovery-based proteomics approach identifies protein disulphide isomerase (PDIA1) as a biomarker of β cell stress in type 1 diabetes.

Applications

Unspecified application

Species

Unspecified reactive species

Farooq Syed,Divya Singhal,Koen Raedschelders,Preethi Krishnan,Robert N Bone,Madeline R McLaughlin,Jennifer E Van Eyk,Raghavendra G Mirmira,Mei-Ling Yang,Mark J Mamula,Huanmei Wu,Xiaowen Liu,Carmella Evans-Molina
View all publications
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