AB25973

Anti-GIP 抗体

Name: Anti-GIP 抗体 (ab25973) | Abcam
Brand: Abcam Limited
SKU: AB25973
Price: 73000 JPY
Availability: InStock
Rating: 4 (1 reviews)

Anti-GIP antibody

(1 Review)

(4 Publications)

Rabbit Polyclonal GIP antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 4 publications. Immunogen corresponding to Synthetic Peptide within Human C1QTNF1.

別名を表示する

CTRP1, UNQ310/PRO353, C1QTNF1, Complement C1q tumor necrosis factor-related protein 1, G protein-coupled receptor-interacting protein, GIP

3 Images

Immunocytochemistry/ Immunofluorescence - Anti-GIP antibody (AB25973)

ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-GIP antibody (AB25973)

Immunofluorescence of CTRP1 in Human Kidney cells using ab25973 at 20 ug/ml.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GIP antibody (AB25973)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GIP antibody (AB25973)

ab25973 at 10μg/ml staining GIP in human kidney tissue by IHC

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Western blot - Anti-GIP antibody (AB25973)

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Western blot - Anti-GIP antibody (ab25973) at 1 µg/mL

Lane 2:

Western blot - Anti-GIP antibody (ab25973) at 2 µg/mL

All lanes:

Human kidneycell lysate

Predicted band size: 32 kDa

Observed band size: 30 kDa

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Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

ICC/IF, WB, IHC-P

applications

免疫原

Synthetic Peptide within Human C1QTNF1. The exact immunogen used to generate this antibody is proprietary information.

Q9BXJ1

特異性

ab25973 recognises GIP (G protein coupled receptor interacting protein 1, GIP).

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1 µg/mL", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "10 µg/mL", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "20 µg/mL", "ICCIF-species-notes": "" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

+4°C

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The Glucose-dependent Insulinotropic Polypeptide (GIP) also known as gastric inhibitory polypeptide is a hormone with a molecular mass around 5 kDa. It is a 42-amino acid peptide secreted by the K cells in the duodenum and jejunum of the small intestine. This protein interacts with the GIP receptor which is found in various tissues including pancreatic beta cells adipose tissue and the central nervous system. Researchers utilize GIP ELISA for detecting and quantifying this peptide in research studies.

Biological function summary

The GIP plays a significant role in stimulating insulin secretion in response to glucose intake which does not function alone. It works as part of the enteroinsular axis influencing nutrient uptake and metabolism. GIP also regulates fat metabolism by acting on adipocytes therefore playing a part in energy homeostasis. The exploration of GIP activity often involves MSD assay development to better understand its biological implications.

Pathways

The glucose-stimulated insulin secretion pathway incorporates GIP to enhance the release of insulin from the pancreas. It interacts with other proteins such as insulin and glucagon-like peptide-1 (GLP-1) to exert its glucose-lowering effects. GIP's involvement in the incretin pathway supports the body's maintenance of energy balance and glucose homeostasis under normal physiological conditions.

Glucose homeostasis dysfunction links GIP to type 2 diabetes and obesity. Impairments in GIP secretion or receptor signaling are associated with these metabolic disorders. Studies suggest that dysregulation of GIP along with related proteins like insulin can contribute to disease progression. By targeting GIP researchers at places like Abcam are looking for potential therapies to tackle these health challenges.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

See full target information C1QTNF1

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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Frontiers in physiology 15:1357730 PubMed38595641

2024

Expression of glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide in the rat submandibular gland is influenced by pre- and post-natal high-fat diet exposure.

Applications

Unspecified application

Species

Unspecified reactive species

Pornchanok Sangsuriyothai,Ippei Watari,Saranya Serirukchutarungsee,Sirichom Satrawaha,Katarzyna Anna Podyma-Inoue,Takashi Ono

Biomolecules & biomedicine 24:939-951 PubMed38498315

2024

Dynamic network biomarker C1QTNF1 regulates tumor formation at the tipping point of hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Haoyuan Yu,Xijing Yan,Guanxing Chen,Rong Li,Zhou Yang,Zhixing Liang,Linsen Ye,Yunhao Chen,Yang Li

International journal of molecular sciences 24: PubMed37047812

2023

C1q/TNF-Related Proteins 1, 6 and 8 Are Involved in Corneal Epithelial Wound Closure by Targeting Relaxin Receptor RXFP1 In Vitro.

Applications

Unspecified application

Species

Unspecified reactive species

Hagen Fabian Nicolaus,Thomas Klonisch,Friedrich Paulsen,Fabian Garreis

International journal of molecular medicine 48: PubMed34278465

2021

Bruton's tyrosine kinase regulates macrophage‑induced inflammation in the diabetic kidney via NLRP3 inflammasome activation.

Applications

Unspecified application

Species

Unspecified reactive species

Jing Zhao,Juan Chen,Yuan-Yuan Li,Ling-Ling Xia,Yong-Gui Wu

View all publications

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代替製品

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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GIP antibody [EPR20410] (AB209792)

Abcam product promise

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