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AB150575

Anti-GHRHR 抗体 - C-terminal

Anti-GHRHR antibody - C-terminal

3

(1 Review)

|

(1 Publication)

Rabbit Polyclonal GHRHR antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human Growth hormone-releasing hormone receptor.

別名を表示する

Growth hormone-releasing hormone receptor, GHRH receptor, Growth hormone-releasing factor receptor, GRF receptor, GRFR, GHRHR

1 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GHRHR antibody - C-terminal (AB150575)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GHRHR antibody - C-terminal (AB150575)

Immunohistochemical analysis of formalin-fixed, paraffin embedded Human anterior pituitary tissue labeling GHRHR with ab150575 at 16ug/ml.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

IHC-P

applications

免疫原

Synthetic Peptide within Human Growth hormone-releasing hormone receptor. The exact immunogen used to generate this antibody is proprietary information.

Q02643

特異性

BLAST analysis of the peptide immunogen showed no homology with other Human proteins.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "16 µg/mL", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval before commencing with IHC staining protocol." }, "Mouse": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Common marmoset": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Gorilla": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Hamster": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Monkey": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rabbit": { "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

GHRHR also known as the growth hormone-releasing hormone receptor is an important protein that plays an important role mechanistically in the human body. This receptor is located on the cell membrane and binds to growth hormone-releasing hormone (GHRH). GHRHR is expressed predominantly in the pituitary gland. It has a molecular mass of approximately 44 kDa and its activation leads to the intracellular signaling cascades that promote growth hormone secretion.
Biological function summary

The interaction of GHRHR with GHRH is necessary for the regulation of growth hormone release. This receptor is not part of a larger complex; instead it functions individually as a receptor. GHRHR's role in stimulating growth hormone release makes it essential for normal growth metabolism and body composition. It influences processes like protein synthesis lipolysis and the maintenance of normal glucose levels.

Pathways

GHRHR operates within the growth hormone signaling pathway. This pathway involves the activation of GHRHR by GHRH which leads to the stimulation of adenylate cyclase increasing cyclic AMP levels resulting in growth hormone release. This pathway is interconnected with other signaling proteins like somatostatin which acts as an inhibitor of growth hormone secretion providing a balance in growth regulation.

GHRHR has been linked to conditions affecting growth such as dwarfism and gigantism. Mutations in the GHRHR gene can disrupt normal growth hormone signaling leading to reduced or excessive growth. Gigantism involves increased growth hormone secretion often related to pituitary gland abnormalities. In contrast dwarfism may result from insufficient growth hormone action due to receptor defects. GHRHR's interaction with GHRH and its role in growth hormone regulation highlight its significance in these growth-related disorders.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.
See full target information Growth hormone-releasing hormone receptor
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 32:1313-1322 PubMed28206609

2017

Sphingosine-1-phosphate and its receptors in anti-neutrophil cytoplasmic antibody-associated vasculitis.

Applications

Unspecified application

Species

Unspecified reactive species

Xiao-Jing Sun,Chen Wang,Lu-Xia Zhang,Feng Yu,Min Chen,Ming-Hui Zhao
View all publications
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