Anti-GHRHR 抗体 (ab28692)
Key features and details
- Rabbit polyclonal to GHRHR
- Suitable for: IHC-P
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-GHRHR antibody
GHRHR 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to GHRHR -
由来種
Rabbit -
アプリケーション
適用あり: IHC-Pmore details -
種交差性
交差種: Human -
免疫原
Synthetic peptide:
RTRAKWTTPSRSAAKVLTSM
conjugated to KLH, corresponding to amino acids 403-422 of Human GHRHR -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
Preservative: 0.05% Sodium azide
Constituent: Whole serum -
Concentration information loading...
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精製度
Whole antiserum -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab28692の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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IHC-P |
1/1000. Perform heat mediated antigen retrieval via the microwave method before commencing with IHC staining protocol.
Perform heat mediated antigen retrieval via the microwave method for 20 minutes in citric acid at pH 6.0. |
特記事項 |
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IHC-P
1/1000. Perform heat mediated antigen retrieval via the microwave method before commencing with IHC staining protocol. Perform heat mediated antigen retrieval via the microwave method for 20 minutes in citric acid at pH 6.0. |
ターゲット情報
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機能
Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion. -
組織特異性
Pituitary gland. -
関連疾患
Defects in GHRHR are a cause of growth hormone deficiency isolated type 1B (IGHD1B) [MIM:612781]; also known as dwarfism of Sindh. IGHD1B is an autosomal recessive deficiency of GH which causes short stature. IGHD1B patients have low but detectable levels of GH. -
配列類似性
Belongs to the G-protein coupled receptor 2 family. -
細胞内局在
Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 2692 Human
- Omim: 139191 Human
- SwissProt: Q02643 Human
- Unigene: 767 Human
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別名
- GHRFR antibody
- GHRH R antibody
- GHRH receptor antibody
see all
画像
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (27)
ab28692 は 27 報の論文で使用されています。
- Boido M et al. Agonist of growth hormone-releasing hormone improves the disease features of spinal muscular atrophy mice. Proc Natl Acad Sci U S A 120:e2216814120 (2023). PubMed: 36603028
- Kubra KT et al. Growth Hormone-Releasing Hormone Antagonist JV-1-36 Suppresses Reactive Oxygen Species Generation in A549 Lung Cancer Cells. Endocrines 3:813-820 (2022). PubMed: 36540765
- Akhter MS & Barabutis N Suppression of reactive oxygen species in endothelial cells by an antagonist of growth hormone-releasing hormone. J Biochem Mol Toxicol 35:e22879 (2021). PubMed: 34369038
- Pech-Pool S et al. Thyrotropin-Releasing Hormone (TRH) and Somatostatin (SST), but not Growth Hormone-Releasing Hormone (GHRH) nor Ghrelin (GHRL), Regulate Expression and Release of Immune Growth Hormone (GH) from Chicken Bursal B-Lymphocyte Cultures. Int J Mol Sci 21:N/A (2020). PubMed: 32093298
- Barabutis N et al. GHRH Antagonists Protect Against Hydrogen Peroxide-Induced Breakdown of Brain Microvascular Endothelium Integrity. Horm Metab Res 52:336-339 (2020). PubMed: 32403147