AB85104

Anti-Ghrelin Receptor/GHS-R 抗体

Name: Anti-Ghrelin Receptor/GHS-R 抗体 (ab85104) | Abcam
Brand: Abcam Limited
SKU: AB85104
Price: 72000 JPY
Availability: InStock
Rating: 4 (4 reviews)

Anti-Ghrelin Receptor/GHS-R antibody

(4 Reviews)

(13 Publications)

Rabbit Polyclonal Ghrelin Receptor/GHS-R antibody. Suitable for WB, IHC-P and reacts with Rat, Human samples. Cited in 13 publications.

別名を表示する

Growth hormone secretagogue receptor type 1, GHS-R, GH-releasing peptide receptor, Ghrelin receptor, GHRP, GHSR

2 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ghrelin Receptor/GHS-R antibody (AB85104)

IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ghrelin Receptor/GHS-R antibody (AB85104)

ab85104 at 1/200 dilution staining Ghrelin Receptor/GHS-R in human fetal brain tissue section by immunohistochemistry (Formalin/ PFA fixed, paraffin-embedded tissue sections).

Unknown

Western blot - Anti-Ghrelin Receptor/GHS-R antibody (AB85104)

Rat liver lysate, 1 : 500 dilution.

All lanes:

Western blot - Anti-Ghrelin Receptor/GHS-R antibody (ab85104)

Predicted band size: 41 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Rat, Human

アプリケーション

IHC-P, WB

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/200", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/200 - 1/1000", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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出荷温度及び保存条件

製品の状態

Lyophilized

再構成

reconstitute with water at 200µL

精製方法

Affinity purification Immunogen

バッファー組成

Preservative: 0.02% Sodium azide Constituents: 2% BSA

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The Ghrelin Receptor also known as GHS-R or GHSR is a G protein-coupled receptor responsible for binding ghrelin the hunger hormone which is a ligand composed of ghrelin peptides. The receptor weighing approximately 44 kDa exhibits a chemical structure typical for G-protein-coupled receptors which enables signal transduction across cell membranes. The receptor is expressed extensively in the hypothalamus pituitary gland and other peripheral tissues including heart and adipose tissue indicating its widespread role in energy homeostasis.

Biological function summary

This target modulates several physiological processes. It notably has a significant influence on appetite regulation and energy balance reflecting its function as part of the larger neuroendocrine system. The Ghrelin Receptor does not form a larger protein complex but interacts directly with ghrelin analogues to mediate its effects. This interaction plays a critical role in stimulating growth hormone release influencing metabolic processes.

Pathways

The Ghrelin Receptor is integral to the growth hormone secretagogue pathway where it interacts closely with the growth hormone-releasing hormone receptor (GHRHR). This pathway exemplifies the receptor’s role in energy metabolism and regulation of body composition. In addition to this the receptor is involved in neuroendocrine signaling pathways impacting appetite and feeding behaviors by signaling to orexigenic neurons in the arcuate nucleus of the hypothalamus.

Research indicates that dysregulation of Ghrelin Receptor activity is linked to obesity and metabolic syndromes. Alterations in ghrelin signaling can lead to abnormal energy balance and fat storage. Moreover the receptor is associated with conditions like Prader-Willi Syndrome where ghrelin levels commonly increase exacerbating feeding behaviors. The Ghrelin Receptor's relationship with the growth hormone and its dynamic interaction with GHRHR also highlight its broader relevance in metabolic and growth-related disorders.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine).

See full target information Growth hormone secretagogue receptor type 1

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文献 (13)

Recent publications for all applications. Explore the full list and refine your search

Canadian journal of gastroenterology & hepatology 2023:1629777 PubMed38187112

2024

Ghrelin/GHSR Axis Induced M2 Macrophage and Alleviated Intestinal Barrier Dysfunction in a Sepsis Rat Model by Inactivating E2F1/NF-B Signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Lei Zhu,Zhimin Dou,Wei Wu,Qiliang Hou,Sen Wang,Ziqian Yuan,Bin Li,Jian Liu

Frontiers in endocrinology 13:932761 PubMed36387867

2022

Involvement of POMC neurons in LEAP2 regulation of food intake and body weight.

Applications

Unspecified application

Species

Unspecified reactive species

Guangpin Chu,Hualing Peng,Nana Yu,Yuejin Zhang,Xueling Lin,Yisheng Lu

International journal of molecular sciences 23: PubMed35409338

2022

Ghrelin Represses Thymic Stromal Lymphopoietin Gene Expression through Activation of Glucocorticoid Receptor and Protein Kinase C Delta in Inflamed Skin Keratinocytes.

Applications

Unspecified application

Species

Unspecified reactive species

Hayan Jeong,Hyo-Jin Chong,Jangho So,Yejin Jo,Tae-Young Yune,Bong-Gun Ju

International journal of molecular sciences 23: PubMed35328456

2022

Effect of Bacterial Infection on Ghrelin Receptor Regulation in Periodontal Cells and Tissues.

Applications

Unspecified application

Species

Unspecified reactive species

Andressa V B Nogueira,Marjan Nokhbehsaim,Anna Damanaki,Sigrun Eick,Svenja Beisel-Memmert,Christian Kirschneck,Agnes Schröder,Thamiris Cirelli,Natalia D P Leguizamón,Joni A Cirelli,James Deschner

Molecular medicine reports 20:5050-5058 PubMed31638214

2019

Effects of β‑hydroxybutyric acid and ghrelin on the motility and inflammation of gastric antral smooth muscle cells involving the regulation of growth hormone secretagogue receptor.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaolin Hu,Li You,Changhua Hu,Juan Wu,Min Ai,Xiaoyan He,Wenjie Huang,Zonghui Wu

American journal of physiology. Gastrointestinal a 316:G453-G461 PubMed30702902

2019

Chronic alcohol exposure alters circulating insulin and ghrelin levels: role of ghrelin in hepatic steatosis.

Applications

Unspecified application

Species

Unspecified reactive species

Karuna Rasineni,Paul G Thomes,Jacy L Kubik,Edward N Harris,Kusum K Kharbanda,Carol A Casey

Cell communication and signaling : CCS 17:8 PubMed30683114

2019

Gut ghrelin regulates hepatic glucose production and insulin signaling via a gut-brain-liver pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Yao Lin,Zerong Liang,Liping He,Mengliu Yang,Dongfang Liu,Harvest F Gu,Hua Liu,Zhiming Zhu,Hongting Zheng,Ling Li,Gangyi Yang

Cell metabolism 27:461-469.e6 PubMed29233536

2017

LEAP2 Is an Endogenous Antagonist of the Ghrelin Receptor.

Applications

Unspecified application

Species

Unspecified reactive species

Xuecai Ge,Hong Yang,Maria A Bednarek,Hadas Galon-Tilleman,Peirong Chen,Michael Chen,Joshua S Lichtman,Yan Wang,Olivier Dalmas,Yiyuan Yin,Hui Tian,Lutz Jermutus,Joseph Grimsby,Cristina M Rondinone,Anish Konkar,Daniel D Kaplan

Mediators of inflammation 2017:4916971 PubMed29317796

2017

Regulation of Ghrelin Receptor by Periodontal Bacteria and .

Applications

IHC

Species

Human

Marjan Nokhbehsaim,Anna Damanaki,Andressa Vilas Boas Nogueira,Sigrun Eick,Svenja Memmert,Xiaoyan Zhou,Shanika Nanayakkara,Werner Götz,Joni Augusto Cirelli,Andreas Jäger,James Deschner

Polish journal of veterinary sciences 20:467-475 PubMed29166288

2017

Spirulina Platensis Affects Factors Involved in Spermatogenesis and Increases Ghrelin Receptors in Testis Tissue of Rats Fed a High-Fat Diet.

Applications

Unspecified application

Species

Unspecified reactive species

O B B Esener,E Gurel-Gurevin,B Isbilen-Basok,F Yigit,T Bilal,A Altiner,N Yilmazer,E I Armutak

View all publications

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Abcam product promise

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Anti-Ghrelin Receptor/GHS-R 抗体

Anti-Ghrelin Receptor/GHS-R antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Ghrelin Receptor/GHS-R antibody (AB85104)

Western blot - Anti-Ghrelin Receptor/GHS-R antibody (AB85104)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

再構成

精製方法

バッファー組成

出荷温度

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (13)

代替製品

Primary Antibodies

Primary Antibodies

組合せ製品

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise