Anti-GFAP 抗体 [6F2] (ab8975)
![Immunohistochemistry (Frozen sections) - Anti-GFAP antibody [6F2] (ab8975)](https://www.abcam.co.jp/ps/products/8/ab8975/Images/ab8975-15929-anti-gfap-antibody-6f2-immunohistochemistry.jpg "Immunohistochemistry (Frozen sections) - Anti-GFAP antibody [6F2] (ab8975)")
Key features and details
- Mouse monoclonal [6F2] to GFAP
- Suitable for: IHC-Fr
- Reacts with: Human
- Isotype: IgG1
製品の概要
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製品名
Anti-GFAP antibody [6F2]
GFAP 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [6F2] to GFAP -
由来種
Mouse -
特異性
Reacts exclusively with glial fibrillary acidic protein which is present in astrocytes in the central nervous system and Schwann cells. -
アプリケーション
適用あり: IHC-Frmore details -
種交差性
交差種: Human -
免疫原
Tissue, cells or virus corresponding to Human GFAP. Glial fibrillary acidic protein (full length) from human brain.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
Preservative: 0.09% Sodium azide
Constituent: PBS -
Concentration information loading... -
精製度
Protein G purified -
ポリ/モノ
モノクローナル -
クローン名
6F2 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
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Related Products
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab8975の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| IHC-Fr |
Use at an assay dependent concentration.
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| 特記事項 |
|---|
|
IHC-Fr
Use at an assay dependent concentration. |
ターゲット情報
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機能
GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells. -
組織特異性
Expressed in cells lacking fibronectin. -
関連疾患
Defects in GFAP are a cause of Alexander disease (ALEXD) [MIM:203450]. Alexander disease is a rare disorder of the central nervous system. It is a progressive leukoencephalopathy whose hallmark is the widespread accumulation of Rosenthal fibers which are cytoplasmic inclusions in astrocytes. The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade. Infants with Alexander disease develop a leukoencephalopathy with macrocephaly, seizures, and psychomotor retardation. Patients with juvenile or adult forms typically experience ataxia, bulbar signs and spasticity, and a more slowly progressive course. -
配列類似性
Belongs to the intermediate filament family. -
翻訳後修飾
Phosphorylated by PKN1. -
細胞内局在
Cytoplasm. Associated with intermediate filaments. - Information by UniProt
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参照データベース
- Entrez Gene: 2670 Human
- Omim: 137780 Human
- SwissProt: P14136 Human
- Unigene: 514227 Human
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別名
- wu:fb34h11 antibody
- ALXDRD antibody
- cb345 antibody
see all
画像
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Immunohistochemistry (Frozen sections) - Anti-GFAP antibody [6F2] (ab8975)
GFAP immunogold labelling TEM of corticobasal degeneration brain tissue showing heavy and highly-specific labelling over a glial process. Bar =
100 nm.This picture was kindly supplied as part of the review submitted by Dr Julian Thorpe (University of Sussex).
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (5)
ab8975 は 5 報の論文で使用されています。
- Luo L et al. Application of bioactive hydrogels combined with dental pulp stem cells for the repair of large gap peripheral nerve injuries. Bioact Mater 6:638-654 (2021). PubMed: 33005828
- Kim B et al. Ontogeny of inter-alpha inhibitor protein (IAIP) expression in human brain. J Neurosci Res 98:869-887 (2020). PubMed: 31797408
- Keren L et al. MIBI-TOF: A multiplexed imaging platform relates cellular phenotypes and tissue structure. Sci Adv 5:eaax5851 (2019). Mass Cytometry . PubMed: 31633026
- Cai S et al. Directed Differentiation of Human Bone Marrow Stromal Cells to Fate-Committed Schwann Cells. Stem Cell Reports 9:1097-1108 (2017). WB ; Human . PubMed: 28890164
- Niapour A et al. Cotransplantation of human embryonic stem cell-derived neural progenitors and schwann cells in a rat spinal cord contusion injury model elicits a distinct neurogenesis and functional recovery. Cell Transplant 21:827-43 (2012). PubMed: 21944670