Anti-Gemin 2 抗体 [EPR10040(B)] (ab150383)
![Western blot - Anti-Gemin 2 antibody [EPR10040(B)] (ab150383)](https://www.abcam.co.jp/ps/products/150/ab150383/Images/Gemin-2-Primary-antibodies-ab150383-1.jpg "Western blot - Anti-Gemin 2 antibody [EPR10040(B)] (ab150383)")
Key features and details
- Produced recombinantly (animal-free) for high batch-to-batch consistency and long term security of supply
- Rabbit monoclonal [EPR10040(B)] to Gemin 2
- Suitable for: WB
- Reacts with: Human
Related conjugates and formulations
製品の概要
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製品名
Anti-Gemin 2 antibody [EPR10040(B)]
Gemin 2 一次抗体 製品一覧 -
製品の詳細
Rabbit monoclonal [EPR10040(B)] to Gemin 2 -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details
適用なし: Flow Cyt,ICC/IF or IHC-P -
種交差性
交差種: Human
交差が予測される動物種: Mouse, Rat
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免疫原
Synthetic peptide within Human Gemin 2 aa 1-100. The exact sequence is proprietary.
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ポジティブ･コントロール
- HepG2, K562 and HeLa cell lysates
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特記事項
This product is a recombinant monoclonal antibody, which offers several advantages including:
- - High batch-to-batch consistency and reproducibility
- - Improved sensitivity and specificity
- - Long-term security of supply
- - Animal-free production
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.2
Preservative: 0.01% Sodium azide
Constituents: 9% PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA, 50% Tissue culture supernatant -
Concentration information loading... -
精製度
Tissue culture supernatant -
ポリ/モノ
モノクローナル -
クローン名
EPR10040(B) -
アイソタイプ
IgG -
研究分野
関連製品
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Alternative Versions
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Isotype control
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Positive Controls
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab150383の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
1/1000 - 1/10000. Predicted molecular weight: 31 kDa.
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| 特記事項 |
|---|
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WB
1/1000 - 1/10000. Predicted molecular weight: 31 kDa. |
追加情報
Is unsuitable for Flow Cyt,ICC/IF or IHC-P.
ターゲット情報
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機能
The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. -
配列類似性
Belongs to the gemin-2 family. -
細胞内局在
Nucleus > gem. Cytoplasm. Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs. Also found in the cytoplasm. - Information by UniProt
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参照データベース
- Entrez Gene: 8487 Human
- Entrez Gene: 66603 Mouse
- Entrez Gene: 84404 Rat
- Omim: 602595 Human
- SwissProt: O14893 Human
- SwissProt: Q9CQQ4 Mouse
- SwissProt: Q9QZP1 Rat
- Unigene: 652307 Human
see all -
別名
- Component of gems 2 antibody
- Gem (nuclear organelle) associated protein 2 antibody
- Gem associated protein 2 antibody
see all
画像
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Western blot - Anti-Gemin 2 antibody [EPR10040(B)] (ab150383)All lanes : Anti-Gemin 2 antibody [EPR10040(B)] (ab150383) at 1/1000 dilution
Lane 1 : HepG2 cell lysate
Lane 2 : K562 cell lysate
Lane 3 : HeLa cell lysate
Lysates/proteins at 10 µg per lane.
Secondary
All lanes : HRP labeled goat anti-rabbit at 1/2000 dilution
Predicted band size: 31 kDa -
![Anti-Gemin 2 antibody [EPR10040(B)] (ab150383)](https://www.abcam.co.jp/ps/products/150/ab150383/Images/ab150383-2-benefits-of-recombinant-antibodies.png)
Anti-Gemin 2 antibody [EPR10040(B)] (ab150383)
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (1)
ab150383 は 1 報の論文で使用されています。
- Rodriguez-Muela N et al. Blocking p62-dependent SMN degradation ameliorates spinal muscular atrophy disease phenotypes. J Clin Invest 128:3008-3023 (2018). PubMed: 29672276