Anti-GDNF Receptor alpha 1/GFRA1 抗体 (ab186855)
Key features and details
- Rabbit polyclonal to GDNF Receptor alpha 1/GFRA1
- Suitable for: ICC/IF, WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-GDNF Receptor alpha 1/GFRA1 antibody
GDNF Receptor alpha 1/GFRA1 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to GDNF Receptor alpha 1/GFRA1 -
由来種
Rabbit -
アプリケーション
適用あり: ICC/IF, WBmore details -
種交差性
交差種: Human -
免疫原
Recombinant fragment corresponding to Human GDNF Receptor alpha 1/GFRA1 aa 25-280.
Database link: P56159 -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Positive Controls
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab186855の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| ICC/IF |
Use at an assay dependent concentration.
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| WB |
1/500 - 1/2000. Predicted molecular weight: 51 kDa.
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| 特記事項 |
|---|
|
ICC/IF
Use at an assay dependent concentration. |
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WB
1/500 - 1/2000. Predicted molecular weight: 51 kDa. |
ターゲット情報
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機能
Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. -
配列類似性
Belongs to the GDNFR family. -
細胞内局在
Cell membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 2674 Human
- Omim: 601496 Human
- SwissProt: P56159 Human
- Unigene: 388347 Human
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別名
- GDNF family receptor alpha 1 antibody
- GDNF family receptor alpha-1 antibody
- GDNF R antibody
see all
画像
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Immunocytochemistry/ Immunofluorescence - Anti-GDNF Receptor alpha 1/GFRA1 antibody (ab186855)Immunocytochemistry/Immunofluorescence analysis of U2OS cells using ab186855. Blue DAPI for nuclear staining.
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Western blot - Anti-GDNF Receptor alpha 1/GFRA1 antibody (ab186855)All lanes : Anti-GDNF Receptor alpha 1/GFRA1 antibody (ab186855) at 1/500 dilution
Lane 1 : MCF7 cell extract
Lane 2 : A549 cell extract
Lane 3 : SW480 cell extract
Predicted band size: 51 kDa
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (4)
ab186855 は 4 報の論文で使用されています。
- Lin Y et al. Thy1-Positive Spermatogonia Suppress the Proliferation of Spermatogonial Stem Cells by Extracellular Vesicles In Vitro. Endocrinology 162:N/A (2021). PubMed: 33713403
- Lei JH et al. Cytotoxicity of nonylphenol on spermatogonial stem cells via phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin pathway. World J Stem Cells 12:500-513 (2020). PubMed: 32742567
- Li W et al. Dl-3-n-Butylphthalide Reduces Cognitive Impairment Induced by Chronic Cerebral Hypoperfusion Through GDNF/GFRa1/Ret Signaling Preventing Hippocampal Neuron Apoptosis. Front Cell Neurosci 13:351 (2019). PubMed: 31456664
- Zhang YP et al. Mifepristone attenuates depression-like changes induced by chronic central administration of interleukin-1ß in rats. Behav Brain Res 347:436-445 (2018). PubMed: 29580890