AB167162

Anti-GAP43 (phospho S41) 抗体 [EPR1854(2)]

Anti-GAP43 (phospho S41) antibody [EPR1854(2)]

RabMAb
Recombinant
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(4 Publications)

Rabbit Recombinant Monoclonal GAP43 phospho S41 antibody. Suitable for WB and reacts with Human samples. Cited in 4 publications.

別名を表示する

Neuromodulin, Axonal membrane protein GAP-43, Growth-associated protein 43, Neural phosphoprotein B-50, pp46, GAP43

1 Images

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Western blot - Anti-GAP43 (phospho S41) antibody [EPR1854(2)] (AB167162)

All lanes:

Western blot - Anti-GAP43 (phospho S41) antibody [EPR1854(2)] (ab167162) at 1/1000 dilution

Lane 1:

Untreated SH-SY5Y cell lysates at 10 µg

Lane 2:

SH-SY5Y cell lysates treated with Okadaic Acid and Calyculin A. at 10 µg

Predicted band size: 24 kDa

false

Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR1854(2)

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/1000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Mouse": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "", "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "notRecommended", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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製品の詳細

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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出荷温度及び保存条件

製品の状態

Liquid

精製度

Tissue culture supernatant

バッファー組成

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 50% Tissue culture supernatant, 40% Glycerol (glycerin, glycerine), 0.05% BSA

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

GAP43 commonly called Growth Associated Protein 43 or neuronal marker is a protein with a molecular weight of approximately 25-50 kDa. Researchers identify it by various names including GAP-43 GAP43 anticuerpo or GAP43 neuronal marker. This protein exhibits a specific presence in the nervous system especially in axons of neurons. It has significant expression during neural development and regeneration indicating its role in growth and repair.

Biological function summary

GAP43 plays an important role in neurite outgrowth and synaptic plasticity. It functions as an important mediator of signal transduction in neurons. GAP43 does not act alone but integrates into a network of signaling pathways that guide axonal elongation and branching. It works closely with cytoskeletal elements influencing the structural dynamics needed for effective neuronal response and adaptation.

Pathways

GAP43 is vital in the regulation of the protein kinase C pathway and the cAMP pathway both essential for neuronal growth and differentiation. It closely interacts with proteins such as calmodulin which binds to GAP43 and impacts its function in those pathways. These interactions highlight its role in the modulation of neuronal growth and synaptic plasticity making it essential for neurons' response to environmental signals.

GAP43 associates with neurodegenerative diseases and cognitive disorders particularly Alzheimer's disease and schizophrenia. Changes in GAP43 expression levels correlate with the severity and progression of these conditions. Additionally GAP43 connects to other proteins implicated in such diseases like tau in Alzheimer's suggesting a multifaceted involvement in disease mechanisms. This makes it a target of interest for therapeutic research as modulating GAP43 activity might alter disease progression.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.

See full target information GAP43 phospho S41

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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Biology 14: PubMed40906138

2025

Nanogel Loaded with Leaf-Derived Exosome-like Nanovesicles and Indomethacin for the Treatment of Inflammatory Arthritis.

Applications

Unspecified application

Species

Unspecified reactive species

Xianqiang Li,Fei Wang,Rui Wang,Yanjie Cheng,Jinhuan Liu,Wanhe Luo

Nature communications 15:968 PubMed38320988

2024

A clinically applicable connectivity signature for glioblastoma includes the tumor network driver CHI3L1.

Applications

Unspecified application

Species

Unspecified reactive species

Ling Hai,Dirk C Hoffmann,Robin J Wagener,Daniel D Azorin,David Hausmann,Ruifan Xie,Magnus-Carsten Huppertz,Julien Hiblot,Philipp Sievers,Sophie Heuer,Jakob Ito,Gina Cebulla,Alexandros Kourtesakis,Leon D Kaulen,Miriam Ratliff,Henriette Mandelbaum,Erik Jung,Ammar Jabali,Sandra Horschitz,Kati J Ernst,Denise Reibold,Uwe Warnken,Varun Venkataramani,Rainer Will,Mario L Suvà,Christel Herold-Mende,Felix Sahm,Frank Winkler,Matthias Schlesner,Wolfgang Wick,Tobias Kessler

Renal failure 45:2171886 PubMed36715439

2023

Salt-induced phosphoproteomic changes in the subfornical organ in rats with chronic kidney disease.

Applications

Unspecified application

Species

Unspecified reactive species

Xin Wang,Huizhen Wang,Jiawen Li,Lanying Li,Yifan Wang,Aiqing Li

Journal of cellular physiology 235:2986-3001 PubMed31535381

2019

Role of liraglutide in brain repair promotion through Sirt1-mediated mitochondrial improvement in stroke.

Applications

Unspecified application

Species

Unspecified reactive species

Weiliang He,Haoyuan Wang,Congying Zhao,Xiaochao Tian,Litao Li,Hebo Wang

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-GAP43 (phospho S41) 抗体 [EPR1854(2)]

Anti-GAP43 (phospho S41) antibody [EPR1854(2)]

Western blot - Anti-GAP43 (phospho S41) antibody [EPR1854(2)] (AB167162)

関連する標識済み抗体及び組成の異なる製品 (1)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

製品の詳細

出荷温度及び保存条件

製品の状態

精製度

バッファー組成

出荷温度

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (4)

代替製品

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組合せ製品

Assay Kits

Secondary Antibodies

Primary Antibodies

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Abcam product promise