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AB232772

Anti-GAP43 抗体

Anti-GAP43 antibody

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(4 Publications)

Rabbit Polyclonal GAP43 antibody. Suitable for WB, IHC-P and reacts with Rat, Human, Recombinant full length protein - Human, Pig samples. Cited in 4 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human GAP43.

別名を表示する

Neuromodulin, Axonal membrane protein GAP-43, Growth-associated protein 43, Neural phosphoprotein B-50, pp46, GAP43

6 Images
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GAP43 antibody (AB232772)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GAP43 antibody (AB232772)

Formalin-fixed, paraffin-embedded human glioma tissue stained for GAP43 using ab232772 at 10μg/ml in immunohistochemical analysis. DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GAP43 antibody (AB232772)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GAP43 antibody (AB232772)

Formalin-fixed, paraffin-embedded human brain tissue stained for GAP43 using ab232772 at 10 μg/ml in immunohistochemical analysis. DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GAP43 antibody (AB232772)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GAP43 antibody (AB232772)

Formalin-fixed, paraffin-embedded human breast cancer tissue stained for GAP43 using ab232772 at 10μg/ml in immunohistochemical analysis. DAB staining.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GAP43 antibody (AB232772)
  • IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-GAP43 antibody (AB232772)

Formalin-fixed, paraffin-embedded human pancreatic cancer tissue stained for GAP43 using ab232772 at 10μg/ml in immunohistochemical analysis. DAB staining.

Western blot - Anti-GAP43 antibody (AB232772)
  • WB

Supplier Data

Western blot - Anti-GAP43 antibody (AB232772)

All lanes:

Western blot - Anti-GAP43 antibody (ab232772) at 3 µg/mL

All lanes:

Recombinant human GAP43 protein

Secondary

All lanes:

HRP-Linked Guinea pig Anti-Rabbit Ab at 1/2000 dilution

Predicted band size: 24 kDa,52 kDa

false

Western blot - Anti-GAP43 antibody (AB232772)
  • WB

Supplier Data

Western blot - Anti-GAP43 antibody (AB232772)

All lanes:

Western blot - Anti-GAP43 antibody (ab232772) at 3 µg/mL

Lane 1:

Rat brain tissue

Lane 2:

Pig brain tissue

Secondary

All lanes:

HRP-Linked Guinea pig Anti-Rabbit Ab at 1/2000 dilution

Predicted band size: 24 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Rat, Human, Pig

アプリケーション

IHC-P, WB

applications

免疫原

Recombinant Full Length Protein corresponding to Human GAP43.

P17677

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-5 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "5-20 mg/mL", "IHCP-species-notes": "<p></p>" }, "Rat": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-5 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Chimpanzee": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Macaque monkey": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Orangutan": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Pig": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-5 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Recombinant full length protein - Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1-5 µg/mL", "WB-species-notes": "<p></p>", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
精製に関する特記事項
Antigen-specific affinity chromatography followed by Protein A affinity chromatography.
バッファー組成
pH: 7.4 Preservative: 0.011% Proclin 300 Constituents: PBS, 55.77% Glycerol (glycerin, glycerine)
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

GAP43 commonly called Growth Associated Protein 43 or neuronal marker is a protein with a molecular weight of approximately 25-50 kDa. Researchers identify it by various names including GAP-43 GAP43 anticuerpo or GAP43 neuronal marker. This protein exhibits a specific presence in the nervous system especially in axons of neurons. It has significant expression during neural development and regeneration indicating its role in growth and repair.
Biological function summary

GAP43 plays an important role in neurite outgrowth and synaptic plasticity. It functions as an important mediator of signal transduction in neurons. GAP43 does not act alone but integrates into a network of signaling pathways that guide axonal elongation and branching. It works closely with cytoskeletal elements influencing the structural dynamics needed for effective neuronal response and adaptation.

Pathways

GAP43 is vital in the regulation of the protein kinase C pathway and the cAMP pathway both essential for neuronal growth and differentiation. It closely interacts with proteins such as calmodulin which binds to GAP43 and impacts its function in those pathways. These interactions highlight its role in the modulation of neuronal growth and synaptic plasticity making it essential for neurons' response to environmental signals.

GAP43 associates with neurodegenerative diseases and cognitive disorders particularly Alzheimer's disease and schizophrenia. Changes in GAP43 expression levels correlate with the severity and progression of these conditions. Additionally GAP43 connects to other proteins implicated in such diseases like tau in Alzheimer's suggesting a multifaceted involvement in disease mechanisms. This makes it a target of interest for therapeutic research as modulating GAP43 activity might alter disease progression.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
See full target information GAP43
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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Oncology reports 49: PubMed36896786

2023

Suprabasin enhances the invasion, migration, and angiogenic ability of oral squamous cell carcinoma cells under hypoxic conditions.

Applications

Unspecified application

Species

Unspecified reactive species

Asami Houri,Yoshiki Mukudai,Yuzo Abe,Masataka Watanabe,Maki Nara,Saya Miyamoto,Mai Kurihara,Toshikazu Shimane,Tatsuo Shirota

Aging 13:23603-23619 PubMed34647904

2021

Resveratrol promotes axonal regeneration after spinal cord injury through activating Wnt/β-catenin signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Zimin Xiang,Shuai Zhang,Xiaodong Yao,Libin Xu,Jianwei Hu,Chenghui Yin,Jianmei Chen,Hao Xu

Journal of the American Heart Association 10:e020068 PubMed34369204

2021

Renal Denervation by Noninvasive Stereotactic Radiotherapy Induces Persistent Reduction of Sympathetic Activity in a Hypertensive Swine Model.

Applications

Unspecified application

Species

Unspecified reactive species

Xingxing Cai,Yichen Shen,Yuli Yang,Wei Wang,Li Qian,Jing Cai,Runmin Chi,Shunxuan Yu,Keke Li,Zhixing Wei,Taizhong Chen,Yudong Fei,Yaqin Han,Xiu Chen,Ming Liu,Yifei Liu,Dengbin Wang,Mawei Jiang,Yi-Gang Li

Scientific reports 11:2215 PubMed33500491

2021

Reduction of pTau and APP levels in mammalian brain after low-dose radiation.

Applications

Unspecified application

Species

Unspecified reactive species

Diego Iacono,Erin K Murphy,Soundarya S Avantsa,Daniel P Perl,Regina M Day
View all publications
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代替製品

Primary Antibodies

AB196324

Alexa Fluor® 488 Anti-GAP43 antibody [EP890Y] - Neuronal Marker

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Alexa Fluor® 488 Anti-GAP43 antibody [EP890Y] - Neuronal Marker (AB196324)

  • 4
  • 1
Primary Antibodies

AB208745

PE Anti-GAP43 antibody [EP890Y] - Neuronal Marker

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - PE Anti-GAP43 antibody [EP890Y] - Neuronal Marker (AB208745)

  • 0
  • 0
Primary Antibodies

AB196540

Alexa Fluor® 647 Anti-GAP43 antibody [EP890Y] - Neuronal Marker

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 647 Anti-GAP43 antibody [EP890Y] - Neuronal Marker (AB196540)

  • 0
  • 0
Primary Antibodies

AB167162

Anti-GAP43 (phospho S41) antibody [EPR1854(2)]

RabMAb|Recombinant

Western blot - Anti-GAP43 (phospho S41) antibody [EPR1854(2)] (AB167162)

  • 0
  • 0
Primary Antibodies

AB219582

Anti-GAP43 antibody [EP890Y] - BSA and Azide free

BOND RX™ Validated|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-GAP43 antibody [EP890Y] - BSA and Azide free (AB219582)

  • 4
  • 1
Primary Antibodies

AB75810

Anti-GAP43 antibody [EP890Y] - Neuronal Marker

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials

Flow Cytometry (Intracellular) - Anti-GAP43 antibody [EP890Y] - Neuronal Marker (AB75810)

  • 5
  • 8

組合せ製品

Assay Kits

AB282867

Human GAP43 ELISA Kit

Recombinant|SimpleStep

Sandwich ELISA - Human GAP43 ELISA Kit (AB282867)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB18207

Anti-beta III Tubulin antibody - Neuronal Marker

BOND RX™ Validated|Lab Essentials|KO Validated

Immunocytochemistry/ Immunofluorescence - Anti-beta III Tubulin antibody - Neuronal Marker (AB18207)

  • 5
  • 67
Primary Antibodies

AB32454

Anti-MAP2 antibody - Neuronal Marker

BOND RX™ Validated|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-MAP2 antibody - Neuronal Marker (AB32454)

  • 5
  • 35
Primary Antibodies

AB18258

Anti-PSD95 antibody - Synaptic Marker

BOND RX™ Validated|Lab Essentials

Western blot - Anti-PSD95 antibody - Synaptic Marker (AB18258)

  • 5
  • 40

Abcam product promise

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