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AB134019

Anti-GAP43 抗体

Anti-GAP43 antibody

3

(1 Review)

|

(2 Publications)

Chicken Polyclonal GAP43 antibody. Suitable for ICC/IF and reacts with Mouse samples. Cited in 2 publications. Immunogen corresponding to Synthetic Peptide within Mouse Gap43 conjugated to Keyhole Limpet Haemocyanin.

別名を表示する

Basp2, Gap43, Neuromodulin, Axonal membrane protein GAP-43, Calmodulin-binding protein P-57, Growth-associated protein 43

Key facts

宿主種

Chicken

クローン性

Polyclonal

アイソタイプ

IgY

キャリアフリー

No

交差種

Mouse

アプリケーション

ICC/IF

applications

免疫原

Synthetic Peptide within Mouse Gap43 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P06837

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/1000 - 1/2000", "ICCIF-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
精製に関する特記事項
IgY fractions were purified from the yolks
バッファー組成
pH: 7 Preservative: 0.02% Sodium azide Constituents: PBS, 0.5% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

GAP43 commonly called Growth Associated Protein 43 or neuronal marker is a protein with a molecular weight of approximately 25-50 kDa. Researchers identify it by various names including GAP-43 GAP43 anticuerpo or GAP43 neuronal marker. This protein exhibits a specific presence in the nervous system especially in axons of neurons. It has significant expression during neural development and regeneration indicating its role in growth and repair.
Biological function summary

GAP43 plays an important role in neurite outgrowth and synaptic plasticity. It functions as an important mediator of signal transduction in neurons. GAP43 does not act alone but integrates into a network of signaling pathways that guide axonal elongation and branching. It works closely with cytoskeletal elements influencing the structural dynamics needed for effective neuronal response and adaptation.

Pathways

GAP43 is vital in the regulation of the protein kinase C pathway and the cAMP pathway both essential for neuronal growth and differentiation. It closely interacts with proteins such as calmodulin which binds to GAP43 and impacts its function in those pathways. These interactions highlight its role in the modulation of neuronal growth and synaptic plasticity making it essential for neurons' response to environmental signals.

GAP43 associates with neurodegenerative diseases and cognitive disorders particularly Alzheimer's disease and schizophrenia. Changes in GAP43 expression levels correlate with the severity and progression of these conditions. Additionally GAP43 connects to other proteins implicated in such diseases like tau in Alzheimer's suggesting a multifaceted involvement in disease mechanisms. This makes it a target of interest for therapeutic research as modulating GAP43 activity might alter disease progression.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.
See full target information Gap43
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

iScience 28:113438 PubMed41054506

2025

SARS-CoV-2 infection drives local inflammation of the intestinal epithelium in immunocompromised patients with cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Emil Lou,Christine Luo,Katherine Ladner,Allison Makovec,Phillip Wong,Jeremy Chacon,Eamon Toye,Ella Boytim,Emily Gammon Hawkins,Anthony Patregnani,Emily John,Sanyukta Padmanabhan,Akshat Sarkari,Alison Wong,Julia Stuart,Andrew C Nelson,Brian Betts,Eliseo Eugenin,Justin Hwang

Proceedings of the National Academy of Sciences of 111:2782-7 PubMed24550308

2014

Nuclear compartmentalization of odorant receptor genes.

Applications

ICC/IF

Species

Mouse

Lucia M Armelin-Correa,Luciana M Gutiyama,Débora Y C Brandt,Bettina Malnic
View all publications
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代替製品

Primary Antibodies

AB75810

Anti-GAP43 antibody [EP890Y] - Neuronal Marker

BOND RX™ Validated|RabMAb|Recombinant|Lab Essentials

Flow Cytometry (Intracellular) - Anti-GAP43 antibody [EP890Y] - Neuronal Marker (AB75810)

  • 5
  • 8
Primary Antibodies

AB196324

Alexa Fluor® 488 Anti-GAP43 antibody [EP890Y] - Neuronal Marker

RabMAb|Recombinant

Flow Cytometry (Intracellular) - Alexa Fluor® 488 Anti-GAP43 antibody [EP890Y] - Neuronal Marker (AB196324)

  • 4
  • 1
Primary Antibodies

AB208745

PE Anti-GAP43 antibody [EP890Y] - Neuronal Marker

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - PE Anti-GAP43 antibody [EP890Y] - Neuronal Marker (AB208745)

  • 0
  • 0
Primary Antibodies

AB196540

Alexa Fluor® 647 Anti-GAP43 antibody [EP890Y] - Neuronal Marker

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Alexa Fluor® 647 Anti-GAP43 antibody [EP890Y] - Neuronal Marker (AB196540)

  • 0
  • 0
Primary Antibodies

AB167162

Anti-GAP43 (phospho S41) antibody [EPR1854(2)]

RabMAb|Recombinant

Western blot - Anti-GAP43 (phospho S41) antibody [EPR1854(2)] (AB167162)

  • 0
  • 0
Primary Antibodies

AB219582

Anti-GAP43 antibody [EP890Y] - BSA and Azide free

BOND RX™ Validated|RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-GAP43 antibody [EP890Y] - BSA and Azide free (AB219582)

  • 4
  • 1

組合せ製品

Primary Antibodies

AB154859

Anti-ALKBH2 antibody [EPR6177(2)]

RabMAb|Recombinant|Trial Size

Western blot - Anti-ALKBH2 antibody [EPR6177(2)] (AB154859)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB32454

Anti-MAP2 antibody - Neuronal Marker

BOND RX™ Validated|Lab Essentials

Immunocytochemistry/ Immunofluorescence - Anti-MAP2 antibody - Neuronal Marker (AB32454)

  • 5
  • 35
Primary Antibodies

AB108986

Anti-PGP9.5 antibody [EPR4118] - Neuronal Marker

BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Western blot - Anti-PGP9.5 antibody [EPR4118] - Neuronal Marker (AB108986)

  • 5
  • 12

Abcam product promise

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