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AB23942

Anti-Ganglioside asialo GM2 抗体

Anti-Ganglioside asialo GM2 antibody

5

(1 Review)

|

(4 Publications)

Rabbit Polyclonal Ganglioside asialo GM2 antibody. Suitable for ELISA, WB, TLC and reacts with Chemical samples. Cited in 4 publications.

別名を表示する

Asialo GM 2, Asialo GM 2 ganglioside, Ganglioside asialo GM 2

Key facts

宿主種

Rabbit

クローン性

Polyclonal

キャリアフリー

No

アプリケーション

ELISA, TLC, WB

applications

特異性

No cross-reaction with other carbohydrate epitopes.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "TLC" : {"fullname" : "Thin Layer Chromatography", "shortname":"TLC"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Chemical": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "TLC-species-checked": "guaranteed", "TLC-species-dilution-info": "", "TLC-species-notes": "<p>Phosphate buffered saline (pH 7.4) is the recommended diluent.</p>" } } }
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製品の詳細

This product is a mix of IgG and IgM.
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出荷温度及び保存条件

製品の状態
Liquid
精製度
Whole antiserum
バッファー組成
Constituents: Whole serum
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Ganglioside asialo GM2 also known as GA2 is a biologically active glycolipid mass of approximately 1200 daltons. It typically resides in the outer layer of the plasma membrane of neuronal cells contributing to the structural integrity and functionality of cell membranes. In comparison with ganglioside GM2 asialo GM2 lacks sialic acid which affects its interactions and functions at the cellular level.
Biological function summary

This ganglioside plays an essential role in intercellular recognition and communication by participating in cell adhesion and signaling processes. It functions as part of glycoproduct complexes which impact the formation of signaling domains. These complexes influence synaptic stability and plasticity which are important for the functioning of the nervous system. Due to its structural properties asialo GM2 may also interact with proteins related to signaling pathways.

Pathways

Asialo GM2 influences neural signaling and development pathways. It associates with important cascade reactions including the PI3K/AKT signaling pathway which affects cell survival and metabolism. Additionally it potentially interacts with other glycolipids and proteins like integrins which play parts in cell adhesion and signal transmission. This interaction can modulate how cells respond to extracellular signals and maintain homeostasis.

Asialo GM2 relates notably to autoimmune neuropathies and neurodegenerative diseases. Anti-ganglioside antibodies targeting asialo GM2 may arise in conditions like Guillain-Barré syndrome an acute inflammatory disorder affecting the peripheral nervous system. These antibodies can damage neuronal gangliosides leading to nerve signal disruption. Additionally asialo GM2 may have impacts on the development of other neurodegenerative conditions where it interacts with neuropathy-associated proteins exacerbating disease progressions.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

See full target information Ganglioside asialo GM2
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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

International journal of biological sciences 21:433-453 PubMed39744431

2025

Ganglioside GA2-mediated caspase-11 activation drives macrophage pyroptosis aggravating intimal hyperplasia after arterial injury.

Applications

Unspecified application

Species

Unspecified reactive species

Yunmin Shi,Tian He,Hong Liu,Xiaodong Li,Zhengxin Li,Qing Wen,Zhaohui Dai,Xuejing Sun,Qian Tan,Wenjing Yang,Youxiang Jiang,Yuanyuan Liu,Hong Yuan,Fang Lei,Yang Yi,Jingjing Cai

Nature communications 15:2553 PubMed38519472

2024

SNX8 enables lysosome reformation and reverses lysosomal storage disorder.

Applications

Unspecified application

Species

Unspecified reactive species

Xinran Li,Cong Xiang,Shilei Zhu,Jiansheng Guo,Chang Liu,Ailian Wang,Jin Cao,Yan Lu,Dante Neculai,Pinglong Xu,Xin-Hua Feng

Heliyon 9:e18082 PubMed37539272

2023

Loss of Flot2 expression in deep cerebellar nuclei neurons of mice with Niemann-Pick disease type C.

Applications

Unspecified application

Species

Unspecified reactive species

Tsu-I Chen,Pei-Chun Hsu,Ni-Chung Lee,Yu-Han Liu,Hao-Chun Wang,Yen-Hsu Lu,Yin-Hsiu Chien,Wuh-Liang Hwu

FASEB journal : official publication of the Federa 22:3617-27 PubMed18591368

2008

Imatinib therapy blocks cerebellar apoptosis and improves neurological symptoms in a mouse model of Niemann-Pick type C disease.

Applications

Unspecified application

Species

Unspecified reactive species

Alejandra R Alvarez,Andrés Klein,Juan Castro,Gonzalo I Cancino,Julio Amigo,Matías Mosqueira,Lina M Vargas,L Fernanda Yévenes,Francisca C Bronfman,Silvana Zanlungo
View all publications
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組合せ製品

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Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

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Primary Antibodies

AB7291

Anti-alpha Tubulin antibody [DM1A] - Loading Control

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Primary Antibodies

AB2900

Anti-EEA1 antibody - Early Endosome Marker

KO Validated|Lab Essentials

Western blot - Anti-EEA1 antibody - Early Endosome Marker (AB2900)

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Primary Antibodies

AB24170

Anti-LAMP1 antibody - Lysosome Marker

BOND RX™ Validated|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-LAMP1 antibody - Lysosome Marker (AB24170)

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