Anti-gamma Synuclein/SNCG 抗体 (ab55424)
Key features and details
- Rabbit polyclonal to gamma Synuclein/SNCG
- Suitable for: ELISA, ICC/IF, IHC-Fr, WB, IHC-P
- Reacts with: Mouse, Rat, Human
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-gamma Synuclein/SNCG antibody
gamma Synuclein/SNCG 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to gamma Synuclein/SNCG -
由来種
Rabbit -
アプリケーション
適用あり: ELISA, ICC/IF, IHC-Fr, WB, IHC-Pmore details -
種交差性
交差種: Mouse, Rat, Human -
免疫原
Synthetic peptide. This information is proprietary to Abcam and/or its suppliers.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C. -
バッファー
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: 50% Glycerol, 0.87% Sodium chloride, PBS
Without Mg+2 and Ca+2 -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab55424の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| ELISA |
Use at an assay dependent concentration.
|
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| ICC/IF | (1) |
Use at an assay dependent concentration.
|
| IHC-Fr | (4) |
Use at an assay dependent concentration.
|
| WB | (3) |
1/500 - 1/1000. Detects a band of approximately 13 kDa (predicted molecular weight: 13 kDa).
|
| IHC-P |
Use at an assay dependent concentration.
|
| 特記事項 |
|---|
|
ELISA
Use at an assay dependent concentration. |
|
ICC/IF
Use at an assay dependent concentration. |
|
IHC-Fr
Use at an assay dependent concentration. |
|
WB
1/500 - 1/1000. Detects a band of approximately 13 kDa (predicted molecular weight: 13 kDa). |
|
IHC-P
Use at an assay dependent concentration. |
ターゲット情報
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機能
Plays a role in neurofilament network integrity. May be involved in modulating axonal architecture during development and in the adult. In vitro, increases the susceptibility of neurofilament-H to calcium-dependent proteases (By similarity). May also function in modulating the keratin network in skin. Activates the MAPK and Elk-1 signal transduction pathway. -
組織特異性
Highly expressed in brain, particularly in the substantia nigra. Also expressed in the corpus callosum, heart, skeletal muscle, ovary, testis, colon and spleen. Weak expression in pancreas, kidney and lung. -
配列類似性
Belongs to the synuclein family. -
翻訳後修飾
Phosphorylated. Phosphorylation by GRK5 appears to occur on residues distinct from the residue phosphorylated by other kinases. -
細胞内局在
Cytoplasm > perinuclear region. Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle. Associated with centrosomes in several interphase cells. In mitotic cells, localized to the poles of the spindle. - Information by UniProt
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参照データベース
- Entrez Gene: 6623 Human
- Entrez Gene: 20618 Mouse
- Entrez Gene: 64347 Rat
- Omim: 602998 Human
- SwissProt: O76070 Human
- SwissProt: Q9Z0F7 Mouse
- SwissProt: Q63544 Rat
- Unigene: 349470 Human
see all -
別名
- BCSG1 antibody
- Breast cancer specific gene 1 protein antibody
- Breast cancer specific protein 1 antibody
see all
画像
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Western blot - Anti-gamma Synuclein/SNCG antibody (ab55424)All lanes : Anti-gamma Synuclein/SNCG antibody (ab55424) at 1/500 dilution
Lane 1 : HT29 cell extract, without immunizing peptide
Lane 2 : HT29 cell extract, with immunizing peptide
Predicted band size: 13 kDa
Observed band size: 13 kDa -
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-gamma Synuclein/SNCG antibody (ab55424)Immunohistochemical analysis of paraffin-embedded human lung carcinoma tissue using ab55424 (1/50 dilution), in the presence or absence of the immunizing peptide.
プロトコール
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (25)
ab55424 は 25 報の論文で使用されています。
- Dias SB et al. Age-Related Changes of the Synucleins Profile in the Mouse Retina. Biomolecules 13:N/A (2023). PubMed: 36671565
- Nadal-Nicolás FM et al. Pan-retinal ganglion cell markers in mice, rats, and rhesus macaques. Zool Res 44:226-248 (2023). PubMed: 36594396
- Liu W et al. Self-formation of concentric zones of telencephalic and ocular tissues and directional retinal ganglion cell axons. Elife 12:N/A (2023). PubMed: 37665325
- Pavia-Collado R et al. Up and Down γ-Synuclein Transcription in Dopamine Neurons Translates into Changes in Dopamine Neurotransmission and Behavioral Performance in Mice. Int J Mol Sci 23:N/A (2022). PubMed: 35163729
- Zeng H et al. Systemic Treatment with Pioglitazone Reverses Vision Loss in Preclinical Glaucoma Models. Biomolecules 12:N/A (2022). PubMed: 35204782