AB29041

Anti-gamma Catenin (phospho Y550) 抗体

Name: Anti-gamma Catenin (phospho Y550) 抗体 (ab29041) | Abcam
Brand: Abcam Limited
SKU: AB29041
Price: 76000 JPY
Availability: InStock

Anti-gamma Catenin (phospho Y550) antibody

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(1 Publication)

Rabbit Polyclonal gamma Catenin phospho Y550 antibody. Suitable for WB and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human JUP phospho Y550 conjugated to Keyhole Limpet Haemocyanin.

別名を表示する

CTNNG, DP3, JUP, Junction plakoglobin, Catenin gamma, Desmoplakin III, Desmoplakin-3

1 Images

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Western blot - Anti-gamma Catenin (phospho Y550) antibody (AB29041)

Western blot analysis of gamma-Catenin immunoprecipitated from lysates prepared from A431 cells treated with pervanadate. The immunoprecipitation was performed using mouse monoclonal anti-gamma-Catenin. The blots were probed with anti-phospho-gamma-Catenin (Tyr-550) antibody. The immunoprecipitated gamma-Catenin was untreated (lane 1) or treated with alkaline phosphatase (lane 2) then probed with the antibody. In addition, the anti-phospho-gamma-Catenin (Tyr-550) was used in the presence of phospho-gamma-Catenin (Tyr-550) peptide (lane 3) or phospho-gamma-Catenin (Tyr-644) peptide (lane 4).

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Western blot - Anti-gamma Catenin (phospho Y550) antibody (ab29041)

Predicted band size: 82 kDa

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Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

applications

免疫原

Synthetic Peptide within Human JUP phospho Y550 conjugated to Keyhole Limpet Haemocyanin. The exact immunogen used to generate this antibody is proprietary information.

P14923

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Reactivity data

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

精製に関する特記事項

ab29041 was cross adsorbed to both phospho tyrosine coupled to agarose and to dephosphorylated gamma Catenin (Tyr550) peptide before immunogen affinity purification (without carrier protein).

バッファー組成

Preservative: 0.05% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.1% BSA

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Gamma Catenin also known as Junction Plakoglobin (JUP) is a protein with a molecular mass of approximately 82 kDa. It plays an important role in cell adhesion mechanisms. This protein is expressed widely in various tissue types prominently in epithelial tissues. Gamma Catenin contributes significantly to the structure of adherens junctions and desmosomes physically connecting cells to one another and stabilizing those connections within tissues.

Biological function summary

Gamma Catenin is an integral component of the armadillo family of proteins and part of desmosomal and adherens junction complexes. It plays an essential role in maintaining the integrity and mechanical strength of tissues. Through interacting with other proteins in these complexes gamma Catenin facilitates cell signaling and communication. It associates with cadherins and catenins including plakophilin and β-catenin to ensure proper cell-cell adhesion and signaling across the cell membrane.

Pathways

Gamma Catenin is involved in the Wnt signaling pathway an important route governing cellular processes such as proliferation differentiation and migration. Gamma Catenin interacts with β-catenin in this pathway influencing transcriptional regulation in the nucleus. It also plays roles in the cadherin-mediated cell adhesion pathway working alongside other proteins like E-cadherin to modulate cell behavior. These pathways highlight its importance in cellular architecture and signaling.

Alterations in gamma Catenin expression or function relate to conditions such as heart diseases specifically arrhythmogenic right ventricular cardiomyopathy and cancer particularly affecting epithelial tissues. In these conditions abnormal gamma Catenin interactions with other junction proteins like desmoplakin and plakophilin contribute to disease progression. These disruptions suggest its potential as a therapeutic target providing insight into disease mechanisms and opportunities for intervention.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

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ターゲットの情報

Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton (By similarity).

See full target information JUP phospho Y550

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Leukemia 27:336-43 PubMed22858986

2012

γ-Catenin is overexpressed in acute myeloid leukemia and promotes the stabilization and nuclear localization of β-catenin.

Applications

Unspecified application

Species

Unspecified reactive species

R G Morgan,L Pearn,K Liddiard,S L Pumford,A K Burnett,A Tonks,R L Darley

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-gamma Catenin (phospho Y550) 抗体

Anti-gamma Catenin (phospho Y550) antibody

Western blot - Anti-gamma Catenin (phospho Y550) antibody (AB29041)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

精製に関する特記事項

バッファー組成

出荷温度

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (1)

代替製品

Primary Antibodies

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Primary Antibodies

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組合せ製品

Primary Antibodies

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise