Anti-GABARAP 抗体 (ab1398)
Key features and details
- Rabbit polyclonal to GABARAP
- Suitable for: ELISA, WB
- Reacts with: Mouse, Human
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-GABARAP antibody
GABARAP 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to GABARAP -
由来種
Rabbit -
特異性
This antibody recognizes human GABARAP (14 kD). -
アプリケーション
適用あり: ELISA, WBmore details -
種交差性
交差種: Mouse, Human -
免疫原
Synthetic peptide:
RSEGEKIRKKYPDRVPV
, corresponding to amino acids 15-31 of Human GABARAP. -
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.4
Preservative: 0.02% Sodium azide -
Concentration information loading...
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精製度
Affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab1398の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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ELISA |
Use at an assay dependent concentration.
|
|
WB | (1) |
Use at an assay dependent concentration.
|
特記事項 |
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ELISA
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. |
ターゲット情報
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機能
Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in apoptosis. Involved in autophagy. Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. -
組織特異性
Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas. -
配列類似性
Belongs to the ATG8 family. -
翻訳後修飾
The precursor molecule is cleaved by ATG4B to form the cytosolic form, GABARAP-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, GABARAP-II. -
細胞内局在
Endomembrane system. Cytoplasm, cytoskeleton. Golgi apparatus membrane. Cytoplasmic vesicle, autophagosome. Largely associated with intracellular membrane structures including the Golgi apparatus and postsynaptic cisternae. Colocalizes with microtubules (By similarity). Localizes also to discrete punctae along the ciliary axoneme (By similarity). - Information by UniProt
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参照データベース
- Entrez Gene: 11337 Human
- Entrez Gene: 56486 Mouse
- Omim: 605125 Human
- SwissProt: O95166 Human
- SwissProt: Q9DCD6 Mouse
- Unigene: 647421 Human
- Unigene: 272460 Mouse
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別名
- ATG8A antibody
- FLC 3B antibody
- FLC3B antibody
see all
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (5)
ab1398 は 5 報の論文で使用されています。
- Sun C et al. BmCaspase-8-like regulates autophagy by suppressing BmDREDD-mediated cleavage of BmATG6. Insect Sci 30:365-374 (2023). PubMed: 36044542
- Sujkowski A et al. Endurance exercise ameliorates phenotypes in Drosophila models of spinocerebellar ataxias. Elife 11:N/A (2022). PubMed: 35170431
- Li L et al. Proteomic analysis of differentially expressed proteins in kidneys of brain dead rabbits. Mol Med Rep 16:215-223 (2017). WB ; Rabbit . PubMed: 28534953
- Ning HJ et al. Propofol reduces hypoxia-induced autophagic cell death through downregulating HIF 1a in alveolar epithelial type II cells of rats. Mol Med Rep 16:1509-1515 (2017). PubMed: 28586054
- Belichenko PV et al. Excitatory-inhibitory relationship in the fascia dentata in the Ts65Dn mouse model of Down syndrome. J Comp Neurol 512:453-66 (2009). Mouse . PubMed: 19034952