AB153960

Anti-FVT1 抗体

Name: Anti-FVT1 抗体 (ab153960) | Abcam
Brand: Abcam Limited
SKU: AB153960
Price: 74000 JPY
Availability: InStock

Anti-FVT1 antibody

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(3 Publications)

Rabbit Polyclonal FVT1 antibody. Suitable for WB and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human KDSR aa 50 to C-terminus.

別名を表示する

FVT1, SDR35C1, KDSR, 3-ketodihydrosphingosine reductase, KDS reductase, 3-dehydrosphinganine reductase, Follicular variant translocation protein 1, Short chain dehydrogenase/reductase family 35C member 1, FVT-1

1 Images

Unknown

Western blot - Anti-FVT1 antibody (AB153960)

10% SDS PAGE

All lanes:

Western blot - Anti-FVT1 antibody (ab153960) at 1/1000 dilution

All lanes:

293T whole cell lysate at 30 µg

Predicted band size: 36 kDa

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Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

applications

免疫原

Recombinant Fragment Protein within Human KDSR aa 50 to C-terminus. The exact immunogen used to generate this antibody is proprietary information.

Q06136

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

FVT1 also known as Lipin-1 is a phosphatidate phosphatase enzyme primarily involved in lipid metabolism. The protein has a molecular mass of approximately 100 kDa and expresses significantly in adipose tissue muscle and liver. It regulates the conversion of phosphatidic acid to diacylglycerol an important reaction in triglyceride and phospholipid synthesis. Through its enzymatic activity FVT1 plays roles in lipid droplet formation and storage impacting energy homeostasis in cells.

Biological function summary

FVT1 contributes to the regulation of lipid balance within metabolic processes. It participates in the formation of a complex with other proteins involved in lipid biosynthesis. Lipin-1 modulates transcriptional activation of genes related to lipid metabolism via its interaction with transcription factors like PPARγ. By controlling lipid synthesis and storage it influences cellular lipid composition and energy storage which are important for normal metabolic function.

Pathways

FVT1 lies within the glycerolipid synthesis and fatty acid oxidation pathways. It interacts closely with proteins such as AGPAT and DGAT which are essential for triglyceride synthesis. These pathways involve the conversion of simple glycerol-based molecules into complex lipids which are vital for membrane formation and energy storage. In fatty acid oxidation FVT1 supports energy provision from lipids during metabolic demands.

FVT1 has associations with metabolic conditions such as lipodystrophy and rhabdomyolysis. Mutations in FVT1 can lead to lipin-1 deficiency contributing to muscle weakness and exercise intolerance seen in rhabdomyolysis. Additionally the protein connects to disorders characterized by abnormal lipid storage or metabolism often involving proteins like perilipin and adiponectin. Understanding FVT1's role aids in uncovering novel therapeutic approaches for these metabolic dysfunctions.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Catalyzes the reduction of 3'-oxosphinganine (3-ketodihydrosphingosine/KDS) to sphinganine (dihydrosphingosine/DHS), the second step of de novo sphingolipid biosynthesis.

See full target information KDSR

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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Leukemia 36:100-110 PubMed34373586

2021

3-Ketodihydrosphingosine reductase maintains ER homeostasis and unfolded protein response in leukemia.

Applications

Unspecified application

Species

Unspecified reactive species

Qiao Liu,Anthony K N Chan,Wen-Han Chang,Lu Yang,Sheela Pangeni Pokharel,Kazuya Miyashita,Nicole Mattson,Xiaobao Xu,Mingli Li,Wei Lu,Ren-Jang Lin,Shao-Yuan Wang,Chun-Wei Chen

Journal of cellular and molecular medicine 24:12633-12641 PubMed32945076

2020

Decreased long non-coding RNA lincFOXF1 indicates poor progression and promotes cell migration and metastasis in osteosarcoma.

Applications

Unspecified application

Species

Unspecified reactive species

Shengquan Yang,Jian Chen,Bin Lv,Jun Zhang,Deli Li,Mengyuan Huang,Li Yuan,Guoyong Yin

Journal of proteomics 208:103482 PubMed31401171

2019

Integrated analysis of proteomics and metabolomics reveals the potential sex determination mechanism in Odontobutis potamophila.

Applications

Unspecified application

Species

Unspecified reactive species

Tao Wang,Wenxu Zhu,Hongyan Zhang,Xin Wen,Shaowu Yin,Yongyi Jia

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-FVT1 抗体

Anti-FVT1 antibody

Western blot - Anti-FVT1 antibody (AB153960)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (3)

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise