AB71548

Anti-FSTL1/FRP 抗体

Anti-FSTL1/FRP antibody

3

(1 Review)

|

(12 Publications)

Rabbit Polyclonal FSTL1/FRP antibody. Suitable for WB, IHC-P and reacts with Human samples. Cited in 12 publications.

別名を表示する

FRP, FSTL1, Follistatin-related protein 1, Follistatin-like protein 1

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

IHC-P, WB

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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代替製品

Primary Antibodies

AB223287

Anti-FSTL1/FRP antibody [EPR21933-155]

RabMAb|Recombinant|KO Validated

Immunoprecipitation - Anti-FSTL1/FRP antibody [EPR21933-155] (AB223287)

0
0

Primary Antibodies

AB11805

Anti-FSTL1/FRP antibody

Western blot - Anti-FSTL1/FRP antibody (AB11805)

3
1

Primary Antibodies

AB234961

Anti-FSTL1/FRP antibody [EPR21933-155] - BSA and Azide free

RabMAb|Recombinant|KO Validated

Immunoprecipitation - Anti-FSTL1/FRP antibody [EPR21933-155] - BSA and Azide free (AB234961)

0
0

組合せ製品

Primary Antibodies

AB181602

Anti-GAPDH antibody [EPR16891] - Loading Control

RabMAb|Recombinant|Lab Essentials|20ul selling size

5
23

Primary Antibodies

AB268020

Anti-Fibronectin antibody [EPR23110-46]

KO Validated|RabMAb|Recombinant|Lab Essentials|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Fibronectin antibody [EPR23110-46] (AB268020)

4
5

Primary Antibodies

AB32503

Anti-Bax antibody [E63]

BOND RX™ Validated|20ul selling size|RabMAb|Recombinant|KO Validated

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Bax antibody [E63] (AB32503)

4
12

Primary Antibodies

AB124964

Anti-alpha smooth muscle Actin antibody [EPR5368]

BOND RX™ Validated|RabMAb|Recombinant|KO Validated|20ul selling size

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-alpha smooth muscle Actin antibody [EPR5368] (AB124964)

5
19

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "guaranteed", "WB-species-dilution-info": "", "WB-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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製品の詳細

We are constantly working hard to ensure we provide our customers with best in class antibodies. As a result, we are pleased to offer this antibody in a purified format as of 19th February 2018. The following lots is/are still unpurified and still in stock as of 19th February 2018 - GR200980-7, GR200980-9, GR200980-10. Lot numbers other than GR200980-7, GR200980-9, GR200980-10 will be purified. Please note that the dilutions may need to be adjusted accordingly. Purified antibodies have the advantage of being enriched for the fraction of immunoglobulin that specifically reacts with the target antigen and for having a reduction of serum proteins.

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出荷温度及び保存条件

製品の状態

Lyophilized

再構成

Reconstitute with 100µl Water.

精製方法

Affinity purification Protein A

バッファー組成

Constituents: 2% Sucrose, 1.21% Tris, 0.92% Glycerol (glycerin, glycerine)

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

FSTL1 also known as FRP is a protein that plays an important role in various cellular functions. The protein is a glycoprotein with a molecular mass of approximately 32 kDa and is expressed in a variety of tissues including heart lung and placenta. FSTL1 contains several domains that facilitate its interaction with other proteins and cellular components. It is located both intracellularly and secreted in the extracellular matrix contributing to its role in cell signaling and structural integrity.

Biological function summary

FSTL1 serves as a modulator in inflammatory and developmental processes. It is a part of a complex that regulates immune responses and cell growth. The protein has been shown to affect the activity of multiple growth factors including Bone Morphogenetic Proteins (BMPs) revealing its regulatory capacity in tissue development and repair. FSTL1 can influence cell differentiation proliferation and survival highlighting its significance in maintaining cellular homeostasis.

Pathways

FSTL1 has important roles in the regulation of the BMP signaling and Wnt pathways. In the BMP pathway FSTL1 interacts with other signaling molecules to modulate pathway intensity and cellular outcomes. The protein links with BMP proteins to influence processes like bone formation and tissue repair. In the Wnt pathway FSTL1 can modulate key interactions that affect cellular proliferation and development. Through these pathways FSTL1 also relates to proteins such as TGF-beta which participate in various cellular processes.

FSTL1 has relevance in conditions such as rheumatoid arthritis and pulmonary hypertension. The protein shows increased expression in inflammatory environments indicating its involvement in rheumatoid arthritis where it engages with immune response pathways. The connection with pulmonary hypertension also positions FSTL1 as a significant factor in cardiovascular pathologies. In both conditions FSTL1 interacts with cytokines and other immune-related proteins influencing disease progression and response to treatment.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Secreted glycoprotein that is involved in various physiological processes, such as angiogenesis, regulation of the immune response, cell proliferation and differentiation (PubMed : 22265692, PubMed : 29212066). Plays a role in the development of the central nervous system, skeletal system, lungs, and ureter (By similarity). Promotes endothelial cell survival, migration and differentiation into network structures in an AKT-dependent manner. Also promotes survival of cardiac myocytes (By similarity). Initiates various signaling cascades by activating different receptors on the cell surface such as DIP2A, TLR4 or BMP receptors (PubMed : 20054002, PubMed : 22265692).

See full target information FSTL1

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文献 (12)

Recent publications for all applications. Explore the full list and refine your search

Genome medicine 16:98 PubMed39138551

2024

Spatial multiomics reveals a subpopulation of fibroblasts associated with cancer stemness in human hepatocellular carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Si-Yu Jing,Dan Liu,Na Feng,Hui Dong,He-Qi Wang,Xi Yan,Xu-Feng Chen,Min-Cheng Qu,Ping Lin,Bin Yi,Feiling Feng,Lei Chen,Hong-Yang Wang,Hong Li,Yu-Fei He

Oncology reports 50: PubMed37888756

2023

Analysis of the expression and mechanism of follistatin‑like protein 1 in cervical cancer.

Applications

Unspecified application

Species

Unspecified reactive species

Zhen Liu,Hong Zhang,Xiaoxia Hu

Nature communications 14:6047 PubMed37770480

2023

Metabolic crosstalk between skeletal muscle cells and liver through IRF4-FSTL1 in nonalcoholic steatohepatitis.

Applications

Unspecified application

Species

Unspecified reactive species

Shanshan Guo,Yonghao Feng,Xiaopeng Zhu,Xinyi Zhang,Hui Wang,Ruwen Wang,Qiongyue Zhang,Yiming Li,Yan Ren,Xin Gao,Hua Bian,Tiemin Liu,Huanqing Gao,Xingxing Kong

Frontiers in cardiovascular medicine 9:1050310 PubMed36684598

2023

Role of follistatin-like 1 levels and functions in calcific aortic stenosis.

Applications

Unspecified application

Species

Unspecified reactive species

Qianru Zhang,Jiawen Ye,Gan Yang,Ling Yang,Zhongli Chen,Ke Yang,Jia Teng Sun,Yan Liu

Reproduction (Cambridge, England) 163:57-68 PubMed34866594

2021

Follistatin-like I promotes endometriosis by increasing proinflammatory factors and promoting angiogenesis.

Applications

Unspecified application

Species

Unspecified reactive species

Sha-Ting Lei,Ming-Qing Li,Yan-Ling Cao,Shu-Hui Hou,Hai-Yan Peng,Dong Zhao,Jing Sun

BMC pulmonary medicine 21:45 PubMed33509151

2021

FSTL1 aggravates cigarette smoke-induced airway inflammation and airway remodeling by regulating autophagy.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Liu,Jiawei Xu,Tian Liu,Jinxiang Wu,Jiping Zhao,Junfei Wang,Minfang Zou,Lili Cao,Xiaofei Liu,Yun Pan,Siyuan Huang,Liang Dong

Molecular medicine reports 20:5345-5352 PubMed31638229

2019

Downregulation of FSTL‑1 attenuates the inflammation injury during Streptococcus pneumoniae infection by inhibiting the NLRP3 and TLR4/NF‑κB signaling pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Liang Chen,Zhenshe Liu

Oncology reports 42:2806-2813 PubMed31578589

2019

Follistatin‑like protein 1 knockdown elicits human gastric cancer cell apoptosis via a STAT6‑dependent pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xingang Peng,Peige Wang,Shikuan Li,Yingjun Jiang,Changliang Wu

Oxidative medicine and cellular longevity 2014:294150 PubMed24790701

2014

BMP-2 overexpression augments vascular smooth muscle cell motility by upregulating myosin Va via Erk signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Ming Zhang,Min Yang,Li-ping Liu,Wayne Bond Lau,Hai Gao,Man-kun Xin,Li-Xiao Su,Jian Wang,Shu-Juan Cheng,Qian Fan,Jing-Hua Liu

Genes & development 27:1217-22 PubMed23752588

2013

State-dependent signaling by Cav1.2 regulates hair follicle stem cell function.

Applications

Unspecified application

Species

Unspecified reactive species

Gozde Yucel,Banu Altindag,Natalia Gomez-Ospina,Anshul Rana,Georgia Panagiotakos,Maria Fernanda Lara,Ricardo Dolmetsch,Anthony E Oro

View all publications

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Abcam product promise

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