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AB21011

Anti-FSH 抗体 [INN-hFSH-117]

Anti-FSH antibody [INN-hFSH-117]

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Anti-FSH antibody [INN-hFSH-117] (ab21011) is a mouse monoclonal antibody detecting FSH in ELISA. Suitable for Human.

- Trusted since 2005

別名を表示する

Anterior pituitary glycoprotein hormones common subunit alpha, CG-ALPHA, CGA, Choriogonadotropin alpha chain, Chorionic gonadotrophin alpha subunit, Chorionic gonadotropin alpha polypeptide, FSH A, FSH-alpha, FSH-beta, Follicle Stimulating Hormone Beta, Follicle stimulating hormone beta polypeptide, Follicle stimulating hormone beta subunit, Follitropin alpha chain, Follitropin beta chain, Follitropin subunit beta, GPHA 1, GPHa, Glycoprotein hormones alpha chain, Glycoprotein hormones alpha polypeptide, HCG, LHA, LSH-alpha, Luteinizing hormone alpha chain, Lutropin alpha chain, OTTHUMP00000016825, TSH-alpha, TSHA, Thyroid stimulating hormone alpha chain, Thyrotropin alpha chain, follicle-stimulating hormone alpha chain

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

INN-hFSH-117

アイソタイプ

IgG1

キャリアフリー

No

交差種

Human

アプリケーション

ELISA, RIA

applications

エピトープ

ab21011 recognizes the c1 epitope, a conformational epitope which is only detectable when the alpha and beta subunits of FSH are associated (intact FSH).

特異性

Specific for Human Follicle Stimulating Hormone (FSH) intact. No cross-reaction is detected in RIA with human FSH beta or any other human glycoprotein hormone or subunits thereof.

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Reactivity data

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製品の詳細

What is this antibody validated in?
Anti-FSH antibody [INN-hFSH-117] (ab21011) is a mouse monoclonal antibody and is validated for use in ELISA in Human samples.
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
精製に関する特記事項
>95% pure (SDS-PAGE).
バッファー組成
Preservative: 0.09% Sodium azide Constituents: PBS
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Follicle-stimulating hormone (FSH) is a glycoprotein with a molecular mass of approximately 35 kDa. It is synthesized and secreted by the anterior pituitary gland. FSH sometimes referred to as Follitropin consists of two subunits: the alpha subunit which is common among other pituitary glycoprotein hormones like luteinizing hormone (LH) and thyroid-stimulating hormone (TSH) and the beta subunit which is unique to FSH and imparts its biological specificity. Expression mainly occurs in the pituitary gland and influences various reproductive tissues.
Biological function summary

FSH plays a significant role in the reproductive processes of both males and females. In females it stimulates the growth of ovarian follicles and promotes estrogen production in the ovaries. In males FSH acts on the Sertoli cells of the testes to aid in spermatogenesis. This hormone functions as part of a larger protein complex that interacts with specific FSH receptors on target cells triggering a cascade of intracellular events. These actions involve cyclic adenosine monophosphate (cAMP) as a second messenger and activate related signaling pathways.

Pathways

FSH integrates into the hypothalamic-pituitary-gonadal (HPG) axis a critical regulatory system for reproductive health. FSH is released in response to gonadotropin-releasing hormone (GnRH) and functions in accordance with other related proteins like LH impacting ovarian and testicular function. FSH also participates in the estrogen regulation pathway by modulating estrogen-levels through its action on the ovaries. Interactions with proteins such as inhibin and activin provide feedback control within these pathways.

FSH levels and activity have been linked to conditions such as Polycycstic Ovary Syndrome (PCOS) and hypogonadism. PCOS often involves an imbalance in FSH and LH ratios leading to disrupted follicular development and ovulation issues. In hypogonadism insufficient FSH affects sexual development and reproductive function. FSH-related dysfunctions can also interconnect with other hormonal conditions involving LH and prolactin illustrating its importance in maintaining reproductive health. Researchers use assays like FSH ELISA to measure and study the hormone's levels in these contexts.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

See full target information FSH
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