AB150876

Anti-FRY 抗体

Name: Anti-FRY 抗体 (ab150876) | Abcam
Brand: Abcam Limited
SKU: AB150876
Price: 90000 JPY
Availability: InStock

Anti-FRY antibody

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(1 Publication)

Rabbit Polyclonal FRY antibody. Suitable for IHC-P and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Recombinant Fragment Protein within Human FRY aa 650-750.

別名を表示する

C13orf14, FRY, Protein furry homolog

4 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FRY antibody (AB150876)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FRY antibody (AB150876)

Immunohistochemical analysis of human kidney tissue labeling FRY in the cytoplasm of cells in tubules with ab150876 at a 1/200 dilution.

Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FRY antibody (AB150876)

Immunohistochemical analysis of human endometrium tissue labeling FRY in the cytoplasm of glandular cells with ab150876 at a 1/200 dilution.

Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FRY antibody (AB150876)

Immunohistochemical analysis of human heart muscle tissue labeling FRY in the cytoplasm of myocytes with ab150876 at a 1/200 dilution.

Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FRY antibody (AB150876)

Immunohistochemical analysis of human gastrointestinal tissue labeling FRY in the cytoplasm of glandular cells with ab150876 at a 1/200 dilution.

Performed heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

IHC-P

applications

免疫原

Recombinant Fragment Protein within Human FRY aa 650-750. The exact immunogen used to generate this antibody is proprietary information.

Q5TBA9

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/200 - 1/500", "IHCP-species-notes": "<p></p> Perform heat-mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol." } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

FRY also known as furry homolog or protein fetal andadults-1 is a protein with an approximate mass of 240 kDa. It plays a critical mechanical role in cellular processes by interacting with microtubules which are structures that assist with cell division and shape maintenance. FRY is expressed widely in tissues but shows particularly high levels in the brain liver and lungs indicating its importance in various organ functions. Researchers also notice influence on gene regulation owing to its role in transcriptional activities.

Biological function summary

FRY contributes to diverse cell activities beyond mechanical support. This protein is part of a complex contributing to cell polarity and mitosis essential for proper cell orientation and division. An important function includes its participation in the organization of mitotic spindles structures needed during cell division to evenly separate chromosomes. Given these functions FRY maintains cell structure integrity and supports proper DNA segregation among daughter cells during mitosis.

Pathways

FRY connects to pivotal cellular pathways such as the cell cycle regulation and spindle assembly pathways. It interacts closely with proteins like Aurora kinase B which is vital for correct chromosome alignment and segregation. FRY’s role within these pathways ensures smooth transitions between different cell cycle stages. This integration shows its multifaceted influence in both central and supporting roles concerning cellular dynamics.

Mutations and abnormalities in FRY expression associate with brain-related conditions including glioma and other neurodevelopmental disorders. Research indicates FRY's linkage to cancer development through its interaction with tumor suppressor proteins like p53 which plays a prominent role in cell cycle arrest and apoptosis. These connections suggest FRY's potential as a target for novel disease treatments and better understanding could lead to advances in therapeutic strategies.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

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ターゲットの情報

Plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity by promoting PLK1 activity at the spindle poles in early mitosis. May function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation.

See full target information FRY

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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

iScience 26:106559 PubMed37123228

2023

Multiomic landscape of immune pathogenesis in Kimura's disease.

Applications

Unspecified application

Species

Unspecified reactive species

Xunyao Wu,Anqi Wang,Sumei Zhang,Xiaoxi Wang,Dan Guo,Weiguo Zhu,Yang Jiao,Jiaxin Zhou,Wen Zhang,Linyi Peng,Minghui Duan,Yunyun Fei

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-FRY 抗体

Anti-FRY antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FRY antibody (AB150876)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FRY antibody (AB150876)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FRY antibody (AB150876)

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FRY antibody (AB150876)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (1)

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise