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AB234190

Anti-FOLR2 抗体 [EM-35]

Anti-FOLR2 antibody [EM-35]

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(2 Publications)

Mouse Monoclonal FOLR2 antibody. Suitable for Flow Cyt and reacts with Transfected cell line samples. Cited in 2 publications. Immunogen corresponding to Cell preparation containing FOLR2 protein.

別名を表示する

Folate receptor beta, FR-beta, Folate receptor 2, Placental folate-binding protein, FBP, FOLR2

1 Images
Flow Cytometry - Anti-FOLR2 antibody [EM-35] (AB234190)
  • Flow Cyt

Supplier Data

Flow Cytometry - Anti-FOLR2 antibody [EM-35] (AB234190)

Flow cytometric analysis of FOLR2 transfectants labeling FOLR2 with ab234190 (red) compared with a negative control (blue). Surface staining.

関連する標識済み抗体及び組成の異なる製品 (1)

  • 578 PE

    PE Anti-FOLR2 antibody [EM-35]

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

EM-35

アイソタイプ

IgG1

キャリアフリー

No

アプリケーション

Flow Cyt

applications

免疫原

Cell preparation containing FOLR2 protein. The exact immunogen used to generate this antibody is proprietary information.

P14207

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Mouse": { "FlowCyt-species-checked": "notRecommended", "FlowCyt-species-dilution-info": "1-4 µg/mL", "FlowCyt-species-notes": "<p></p>" }, "Transfected cell line": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1-4 µg/mL", "FlowCyt-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
精製に関する特記事項
Purity > 95% (by SDS-PAGE).
バッファー組成
pH: 7.4 Preservative: 0.0975% Sodium azide Constituents: PBS
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Folate receptor beta also known as FOLR2 is a protein with a molecular mass of approximately 32 kDa. It facilitates the transport of folate into cells. FOLR2 binds folate with high affinity and plays an important role in cellular metabolism. The receptor is mainly expressed in the placenta and certain myeloid cells such as macrophages and monocytes. Its expression is also notable in certain cancer cells but not in most normal tissues.
Biological function summary

Folate receptor beta plays a significant role in folate uptake contributing to DNA synthesis and repair processes. FOLR2 as a part of the cell membrane forms a complex with other molecules to capture and internalize folate from the extracellular environment. This process is essential for the proliferation and survival of cells that require large amounts of folate including developing embryos and certain immune cells.

Pathways

The function of folate receptor beta connects with the folate-mediated one-carbon metabolism pathway critical for nucleotide biosynthesis and methylation reactions. This pathway influences the synthesis of purines and pyrimidines supporting DNA replication and repair. FOLR2 interacts with folate transport proteins and enzymes involved in the methionine cycle which interlinks with amino acid metabolism and epigenetic regulation.

Folate receptor beta is associated with rheumatoid arthritis and ovarian cancer. In rheumatoid arthritis FOLR2 expression on activated macrophages indicates its potential as a biomarker and target for therapy. The overexpression of FOLR2 in ovarian cancer makes it a target for folate-linked therapeutic agents. The relationship between FOLR2 and immune proteins in inflammatory conditions highlights its role in modulating immune responses in disease contexts.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.
See full target information FOLR2
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Breast cancer research : BCR 27:31 PubMed40045365

2025

Unveiling the key mechanisms of FOLR2+ macrophage-mediated antitumor immunity in breast cancer using integrated single-cell RNA sequencing and bulk RNA sequencing.

Applications

Unspecified application

Species

Unspecified reactive species

Sixuan Wu,Baohong Jiang,Zhimin Li,Yuanbin Tang,Lunqi Luo,Wenjie Feng,Yiling Jiang,Yeru Tan,Yuehua Li

PloS one 8:e60136 PubMed23565196

2013

The TNF-family cytokine TL1A inhibits proliferation of human activated B cells.

Applications

Unspecified application

Species

Unspecified reactive species

Chiara Cavallini,Ornella Lovato,Anna Bertolaso,Luciano Pacelli,Elisa Zoratti,Elisabetta Zanolin,Mauro Krampera,Alberto Zamò,Cristina Tecchio,Marco A Cassatella,Giovanni Pizzolo,Maria T Scupoli
View all publications
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