Anti-FKBP12 抗体 [1E5-A12] (ab58072)
![Western blot - Anti-FKBP12 antibody [1E5-A12] (ab58072)](https://www.abcam.co.jp/ps/products/58/ab58072/Images/ab58072-71816-anti-fkbp12-antibody-western-blot.jpg "Western blot - Anti-FKBP12 antibody [1E5-A12] (ab58072)")
Key features and details
- Mouse monoclonal [1E5-A12] to FKBP12
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG1
製品の概要
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製品名
Anti-FKBP12 antibody [1E5-A12]
FKBP12 一次抗体 製品一覧 -
製品の詳細
Mouse monoclonal [1E5-A12] to FKBP12 -
由来種
Mouse -
アプリケーション
適用あり: WBmore details
適用なし: ICC/IF or IHC-P -
種交差性
交差種: Human -
免疫原
Recombinant full length protein, corresponding to amino acids 1-109 of Human FKBP12
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特記事項
This product was changed from ascites to tissue culture supernatant on 24/1/19. Please note that the dilutions may need to be adjusted accordingly. If you have any questions, please do not hesitate to contact our scientific support team.
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.4 -
Concentration information loading... -
精製度
Tissue culture supernatant -
特記事項（精製）
Purified from TCS. -
ポリ/モノ
モノクローナル -
クローン名
1E5-A12 -
アイソタイプ
IgG1 -
軽鎖の種類
kappa -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab58072の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | (2) |
Use at an assay dependent concentration. Predicted molecular weight: 12 kDa.
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| 特記事項 |
|---|
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WB
Use at an assay dependent concentration. Predicted molecular weight: 12 kDa. |
ターゲット情報
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機能
May play a role in modulation of ryanodine receptor isoform-1 (RYR-1), a component of the calcium release channel of skeletal muscle sarcoplasmic reticulum. There are four molecules of FKBP12 per skeletal muscle RYR. PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. -
配列類似性
Belongs to the FKBP-type PPIase family. FKBP1 subfamily.
Contains 1 PPIase FKBP-type domain. -
細胞内局在
Cytoplasm. - Information by UniProt
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参照データベース
- Entrez Gene: 2280 Human
- Omim: 186945 Human
- SwissProt: P62942 Human
- Unigene: 471933 Human
- Unigene: 700839 Human
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別名
- 12 kDa FK506-binding protein antibody
- 12 kDa FKBP antibody
- Calstabin 1 antibody
see all
画像
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Western blot - Anti-FKBP12 antibody [1E5-A12] (ab58072)
FKBP12 antibody (ab58072) at 1μg/lane + HL-60 cell lysate at 25μg/lane.
This image was generated using the ascites version of the product.
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (6)
ab58072 は 6 報の論文で使用されています。
- Wassarman DR et al. Tissue-restricted inhibition of mTOR using chemical genetics. Proc Natl Acad Sci U S A 119:e2204083119 (2022). PubMed: 36095197
- Wang Z et al. A Temporal Examination of Cytoplasmic Ca2 + Levels, Sarcoplasmic Reticulum Ca2 + Levels, and Ca2 + -Handling-Related Proteins in Different Skeletal Muscles of Hibernating Daurian Ground Squirrels. Front Physiol 11:562080 (2020). PubMed: 33192559
- Lotteau S et al. A Mechanism for Statin-Induced Susceptibility to Myopathy. JACC Basic Transl Sci 4:509-523 (2019). PubMed: 31468006
- Højfeldt JW et al. Bifunctional ligands allow deliberate extrinsic reprogramming of the glucocorticoid receptor. Mol Endocrinol 28:249-59 (2014). PubMed: 24422633
- Buheitel J & Stemmann O Prophase pathway-dependent removal of cohesin from human chromosomes requires opening of the Smc3-Scc1 gate. EMBO J 32:666-76 (2013). WB . PubMed: 23361318
- Ström-Olsson K et al. Impact of hypoxia, simulated ischemia and reperfusion in HL-1 cells on the expression of FKBP12/FKBP12.6 and intracellular calcium dynamics. Biochem Biophys Res Commun 422:732-8 (2012). WB ; Mouse . PubMed: 22618235
