FITC Anti-VCAM1 抗体 [M/K-2] (ab24853)
![Flow Cytometry - FITC Anti-VCAM1 antibody [M/K-2] (ab24853)](https://www.abcam.co.jp/ps/products/24/ab24853/Images/ab24853-395935-anti-vcam1-antibody-m-k-2-fitc-flow-cytometry-bone-marrow-cells-mouse.jpg "Flow Cytometry - FITC Anti-VCAM1 antibody [M/K-2] (ab24853)")
Key features and details
- FITC Rat monoclonal [M/K-2] to VCAM1
- Suitable for: Flow Cyt
- Reacts with: Mouse
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG1
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
FITC Anti-VCAM1 antibody [M/K-2]
VCAM1 一次抗体 製品一覧 -
製品の詳細
FITC Rat monoclonal [M/K-2] to VCAM1 -
由来種
Rat -
標識
FITC. Ex: 493nm, Em: 528nm -
アプリケーション
適用あり: Flow Cytmore details -
種交差性
交差種: Mouse -
免疫原
Tissue, cells or virus corresponding to Mouse VCAM1. BALB/3T3 and +/+2.4 cells
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C. Store In the Dark. -
バッファー
pH: 7.4 -
Concentration information loading... -
精製度
Affinity purified -
ポリ/モノ
モノクローナル -
クローン名
M/K-2 -
アイソタイプ
IgG1 -
軽鎖の種類
kappa -
研究分野
関連製品
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Alternative Versions
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab24853の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| Flow Cyt |
Use 1µg for 106 cells.
ab18404 - Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
| 特記事項 |
|---|
|
Flow Cyt
Use 1µg for 106 cells. ab18404 - Rat monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
ターゲット情報
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機能
Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with the beta-1 integrin VLA4 on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/VLA4 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. -
組織特異性
Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue. -
配列類似性
Contains 7 Ig-like C2-type (immunoglobulin-like) domains. -
ドメイン
Either the first or the fourth Ig-like C2-type domain is required for VLA4-dependent cell adhesion. -
翻訳後修飾
Sialoglycoprotein. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 22329 Mouse
- SwissProt: P29533 Mouse
- Unigene: 440909 Mouse
- Unigene: 76649 Mouse
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別名
- CD106 antibody
- CD106 Antigen antibody
- INCAM 100 antibody
see all
画像
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Flow Cytometry - FITC Anti-VCAM1 antibody [M/K-2] (ab24853)
Flow Cytometry analysis of C57BL/6 mouse bone marrow cells stained with anti VCAM1 antibody [M/K-2] (FITC) (ab24853) and Rat Anti-Mouse Ly-6G/Ly-6C-PE. 1 µg of antibody was used for 106 cells.
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (6)
ab24853 は 6 報の論文で使用されています。
- Gkouveris I et al. Vasculature submucosal changes at early stages of osteonecrosis of the jaw (ONJ). Bone 123:234-245 (2019). PubMed: 30953717
- Pagoto A et al. Paramagnetic Phospholipid-Based Micelles Targeting VCAM-1 Receptors for MRI Visualization of Inflammation. Bioconjug Chem 27:1921-30 (2016). PubMed: 27315634
- Zhang ZH et al. Protective effects of BMSCs in combination with erythropoietin in bronchopulmonary dysplasia-induced lung injury. Mol Med Rep 14:1302-8 (2016). PubMed: 27279073
- Zeng SL et al. Mesenchymal stem cells abrogate experimental asthma by altering dendritic cell function. Mol Med Rep 12:2511-20 (2015). PubMed: 25936350
- Acton SE et al. Dendritic cells control fibroblastic reticular network tension and lymph node expansion. Nature 514:498-502 (2014). Flow Cyt . PubMed: 25341788
- Ma M et al. Major histocompatibility complex-I expression on embryonic stem cell-derived vascular progenitor cells is critical for syngeneic transplant survival. Stem Cells 28:1465-75 (2010). Flow Cyt ; Mouse . PubMed: 20629173
