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AB20391

FITC Anti-Respiratory Syncytial Virus 抗体

FITC Anti-Respiratory Syncytial Virus antibody

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(8 Publications)

Goat Polyclonal Respiratory Syncytial Virus antibody - conjugated to FITC. Suitable for ELISA, IHC-P and reacts with Respiratory syncytial virus samples. Cited in 8 publications. Immunogen corresponding to Virus preparation containing Respiratory Syncytial Virus protein.

別名を表示する

RS virus, RSV

Key facts

宿主種

Goat

クローン性

Polyclonal

アイソタイプ

IgG

標識

FITC

励起波長/蛍光波長

Ex: 495nm, Em: 519nm

キャリアフリー

No

交差種

Respiratory syncytial virus

アプリケーション

IHC-P, ELISA

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Respiratory syncytial virus": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "IHCP-species-checked": "guaranteed", "IHCP-species-dilution-info": "", "IHCP-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製度
IgG fraction
バッファー組成
Preservative: 0.1% Sodium azide Constituents: PBS, 1% BSA
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
+4°C
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Respiratory Syncytial Virus (RSV) is a negative-sense single-stranded RNA virus known to cause respiratory infections. It belongs to the Paramyxoviridae family and is sometimes referred to by its alternate names like Human Orthopneumovirus. RSV is approximately 15 kb in size. It is predominantly expressed in the respiratory tract where it attacks epithelial cells leading to infection. The virus's ability to form a syncytium a large multinucleate cell is one of its mechanical strategies to aid in the spread across the host cells.
Biological function summary

The virus propagates efficiently within the host tissue leading to serious respiratory illness in infants and young children. RSV is not part of a specific complex but it engages host cellular machinery to promote its replication and prevent immune detection. The fusion (F) protein of RSV plays a critical role in mediating membrane fusion facilitating viral entry into the host cells. The involvement of viral proteins in modulating host immune responses is significant for the virus's life cycle.

Pathways

Respiratory infections caused by RSV connect to the host's immune signaling pathways including the toll-like receptor (TLR) pathways and the interferon response pathway. The interaction of RSV proteins with these pathways leads to an increased inflammatory response. Proteins such as the RSV G protein interface with the chemokine receptor pathway which helps in modulation of the immune system to allow viral persistence. These interactions demonstrate the virus's strategies to evade immune surveillance and promote infection.

Respiratory syncytial virus is a major cause of bronchiolitis and pneumonia in infants and young children. The virus's activity in the respiratory tract contributes to severe inflammation and cell damage which can lead to hospitalization. Other proteins like RSV M protein are involved in virus assembly and budding and they passively influence disease progression by impacting viral load and the host's immune response. Understanding these interactions is important for developing therapeutic strategies including anti-RSV monoclonal antibodies like palivizumab (2F7) which target prominent viral components to prevent severe disease outcomes.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

See full target information Respiratory Syncytial Virus
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文献 (8)

Recent publications for all applications. Explore the full list and refine your search

Journal of virology 98:e0153624 PubMed39508604

2024

Both chebulagic acid and punicalagin inhibit respiratory syncytial virus entry via multi-targeting glycoprotein and fusion protein.

Applications

Unspecified application

Species

Unspecified reactive species

Yingcai Xiong,Keyu Tao,Tao Li,Yinghui Zhou,Zhaowei Zhang,Weiying Ou,Zhao Wang,Shouchuan Wang,Yayi Hou,Peng Cao,Jianjian Ji

International journal of molecular sciences 24: PubMed38069117

2023

APOBEC3G Is a p53-Dependent Restriction Factor in Respiratory Syncytial Virus Infection of Human Cells Included in the p53/Immune Axis.

Applications

Unspecified application

Species

Unspecified reactive species

Wesley Gladwell,Oriana Yost,Heather Li,Whitney J Bell,Shih-Heng Chen,James M Ward,Steven R Kleeberger,Michael A Resnick,Daniel Menendez

Journal of immunology (Baltimore, Md. : 1950) 199:212-223 PubMed28566367

2017

Heme Oxygenase-1 Modulates Human Respiratory Syncytial Virus Replication and Lung Pathogenesis during Infection.

Applications

Unspecified application

Species

Unspecified reactive species

Janyra A Espinoza,Miguel A León,Pablo F Céspedes,Roberto S Gómez,Gisela Canedo-Marroquín,Sebastían A Riquelme,Francisco J Salazar-Echegarai,Phillipe Blancou,Thomas Simon,Ignacio Anegon,Margarita K Lay,Pablo A González,Claudia A Riedel,Susan M Bueno,Alexis M Kalergis

Journal of virology 90:4876-4888 PubMed26656699

2016

Investigating the Influence of Ribavirin on Human Respiratory Syncytial Virus RNA Synthesis by Using a High-Resolution Transcriptome Sequencing Approach.

Applications

IF

Species

Unspecified reactive species

Waleed Aljabr,Olivier Touzelet,Georgios Pollakis,Weining Wu,Diane C Munday,Margaret Hughes,Christiane Hertz-Fowler,John Kenny,Rachel Fearns,John N Barr,David A Matthews,Julian A Hiscox

The Journal of pharmacy and pharmacology 67:300-18 PubMed25533920

2014

Proteomic analysis of mitochondria in respiratory epithelial cells infected with human respiratory syncytial virus and functional implications for virus and cell biology.

Applications

Unspecified application

Species

Unspecified reactive species

Diane C Munday,Gareth Howell,John N Barr,Julian A Hiscox

American journal of respiratory and critical care medicine 190:196-207 PubMed24941423

2014

Respiratory syncytial virus increases the virulence of Streptococcus pneumoniae by binding to penicillin binding protein 1a. A new paradigm in respiratory infection.

Applications

Unspecified application

Species

Unspecified reactive species

Claire M Smith,Sara Sandrini,Sumit Datta,Primrose Freestone,Sulman Shafeeq,Priya Radhakrishnan,Gwyneth Williams,Sarah M Glenn,Oscar P Kuipers,Robert A Hirst,Andrew J Easton,Peter W Andrew,Christopher O'Callaghan

Journal of virology 85:10300-9 PubMed21795354

2011

Characterization of the interaction between human respiratory syncytial virus and the cell cycle in continuous cell culture and primary human airway epithelial cells.

Applications

Unspecified application

Species

Unspecified reactive species

Weining Wu,Diane C Munday,Gareth Howell,Gareth Platt,John N Barr,Julian A Hiscox

Molecular & cellular proteomics : MCP 9:2438-59 PubMed20647383

2010

Quantitative proteomic analysis of A549 cells infected with human respiratory syncytial virus.

Applications

ICC/IF

Species

Unspecified reactive species

Diane C Munday,Edward Emmott,Rebecca Surtees,Charles-Hugues Lardeau,Weining Wu,W Paul Duprex,Brian K Dove,John N Barr,Julian A Hiscox
View all publications
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