AB270647

FITC Anti-CD206 抗体 [15-2]

Name: FITC Anti-Mannose Receptor 抗体 [15-2] (ab270647) | Abcam
Brand: Abcam Limited
SKU: AB270647
Price: 17000 JPY
Availability: InStock

FITC Anti-CD206 antibody [15-2]

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(16 Publications)

Anti-CD206 antibody [15-2] conjugated to FITC - suitable for flow cytometry, and reacts with human samples. Clone [15-2] is a mouse monoclonal antibody cited in 32 publications.

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別名を表示する

CD206, CLEC13D, CLEC13DL, MRC1L1, MRC1, Macrophage mannose receptor 1, MMR, C-type lectin domain family 13 member D, C-type lectin domain family 13 member D-like, Human mannose receptor, Macrophage mannose receptor 1-like protein 1, hMR

3 Images

Flow Cytometry - FITC Anti-CD206 antibody [15-2] (AB270647)

Flow Cyt

Supplier Data

Flow Cytometry - FITC Anti-CD206 antibody [15-2] (AB270647)

Flow cytometry analysis of dendritic cells differentiated upon monocyte stimulation (GM-CSF + IL-4) (red) and non-stimulated lymphocytes (black) cells labeling CD206 using ab270647. Concentration of 4 μl reagent/100μl peripheral whole blood.

Flow Cyt

Supplier Data

Flow Cytometry - FITC Anti-CD206 antibody [15-2] (AB270647)

Flow cytometry analysis of human stimulated monocytes cells labeling CD206 using ab270647. Concentration of 4 μl reagent per milion cells 100μl of cell suspension.

Flow Cyt

Supplier Data

Flow Cytometry - FITC Anti-CD206 antibody [15-2] (AB270647)

Flow cytometry multicolour surface staining analysis of human stimulated monocytes (GM-CSF + IL-4) cells labeling CD206 using ab270647. Concentration of 4 μl reagent per milion cells in 100μl of cell suspension.

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

15-2

アイソタイプ

IgG1

軽鎖のタイプ

kappa

標識

FITC

励起波長/蛍光波長

Ex: 495nm, Em: 519nm

キャリアフリー

交差種

Human

アプリケーション

Flow Cyt

applications

免疫原

Native Full Length Protein corresponding to Human MRC1.

P22897

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "4 µL for 10^6 Cells", "FlowCyt-species-notes": "<p></p>" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Size-exclusion chromatography

バッファー組成

pH: 7.4 Preservative: 0.1% Sodium azide Constituents: PBS

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

+4°C

保管に関する情報

Store in the dark

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

The CD206 or MRC1 is a type of C-type lectin receptor with a molecular weight of 175 kDa. It is expressed on the surface of macrophages and dendritic cells. This receptor binds to complex carbohydrates like mannose and fucose found on pathogen surfaces playing an important role in their recognition. CD206 acts as endocytic receptors aiding in the internalization and degradation of pathogens.

Biological function summary

The CD206 functions in pathogen recognition and clearance by binding to specific carbohydrates on the pathogen's surface. It is not part of a larger molecular complex but works independently to facilitate phagocytosis. The receptor is essential in immune responses allowing macrophages and dendritic cells to efficiently capture and process antigens for presentation to T cells. This enables the initiation of adaptive immune responses.

Pathways

Researchers know that the CD206 plays an important role in immune signaling pathways particularly in antigen processing and presentation. It interacts with proteins involved in these pathways including those necessary for the internalization and degradation of bound antigens. Moreover it works alongside scavenger receptors contributing to the regulation of immune and inflammatory responses.

The CD206 is often linked to pulmonary tuberculosis and certain types of cancer. When macrophages express this receptor it can modulate immune responses against Mycobacterium tuberculosis by aiding in its recognition. In cancer altered expression of CD206 can indicate tumor-associated macrophages which promote tumor growth by suppressing immune responses. These connections highlight the receptor's potential as a diagnostic marker and therapeutic target.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Mediates the endocytosis of glycoproteins by macrophages. Binds both sulfated and non-sulfated polysaccharide chains.. (Microbial infection) Acts as a phagocytic receptor for bacteria, fungi and other pathogens.. (Microbial infection) Acts as a receptor for Dengue virus envelope protein E.. (Microbial infection) Interacts with Hepatitis B virus envelope protein.

See full target information MRC1

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文献 (16)

Recent publications for all applications. Explore the full list and refine your search

Scientific reports 15:25065 PubMed40645977

2025

Construction of a macrophage-related prognostic signature and assessment of immune checkpoint inhibitor efficacy of HCC.

Applications

Unspecified application

Species

Unspecified reactive species

Shouge Zang,Hongwei Chen,Yuqian Han,Di Cui,Jiangtao Yu

Scientific reports 15:20507 PubMed40592997

2025

Sphingosine 1-phosphate derived from tumor-educated hepatic stellate cells combining with S1PR4 promotes tumor associated macrophages differentiation through FAO modulation.

Applications

Unspecified application

Species

Unspecified reactive species

Rui Feng,Zilin Cui,Long Yang,Zirong Liu

Journal of orthopaedic surgery and research 20:336 PubMed40176111

2025

USP15-modified ADMSCs-Exo alleviates chondrocyte damage and effectively relieved osteoarthritis by inducing M2 polarization of macrophages through deubiquitinating FOXC1.

Applications

Unspecified application

Species

Unspecified reactive species

Qibin Liang,Qinghe Ding,Liang Zhao,Jingchao Tan,Wei Niu

Cancer cell international 25:95 PubMed40089803

2025

ZEB1 promotes the immune escape of ovarian cancer through the MCSF-CCL18 axis.

Applications

Unspecified application

Species

Unspecified reactive species

Yan-Ping Jin,Guo-Wei Li,Qian-Qian Xu,Xiao-Lan Wang

Molecular medicine reports 31: PubMed40052573

2025

N‑methyladenosine reader YTHDF2‑mediated AC026691.1 degradation promotes gastric cancer cell proliferation, migration and M2 macrophage polarization.

Applications

Unspecified application

Species

Unspecified reactive species

Cong-Fei Ji,Jin-Feng Ji,Xiao-Bing Yu,Zhen-Xin Wang

European journal of medical research 30:12 PubMed39773303

2025

GATA1-mediated macrophage polarization via TrkB/cGMP-PKG signaling pathway to promote the development of preeclampsia.

Applications

Unspecified application

Species

Unspecified reactive species

Wushan Li,Fei Hou,Di Cheng,Fengchun Gao,Jin Wang,Baoxia Cui

Journal of biochemical and molecular toxicology 38:e23707 PubMed38622979

2024

M2 macrophage-derived paracrine factor TNFSF13 affects the fibrogenic alterations in endothelial cells and cardiac fibroblasts by mediating the NF-κB and Akt pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaoli Tan,Jintang Wang,Xiangyang Liu,Genyuan Xie,Fan Ouyang

Thoracic cancer 15:227-238 PubMed38087801

2023

Tumor-related exosomal circ_0001715 promotes lung adenocarcinoma cell proliferation and metastasis via enhancing M2 macrophage polarization by regulating triggering receptor expressed on myeloid cells-2.

Applications

Unspecified application

Species

Unspecified reactive species

Mengjun Chen,Chengzhang Cao,Jun Ma

Chinese medicine 18:143 PubMed37919806

2023

Xinyang tablet ameliorates sepsis-induced myocardial dysfunction by regulating Beclin-1 to mediate macrophage autophagy and M2 polarization through LncSICRNT1 targeting E3 ubiquitin ligase TRAF6.

Applications

Unspecified application

Species

Unspecified reactive species

Yuanyuan Luo,Yuanmei Li,Liwei He,Haitao Tu,Xinfeng Lin,Fengli Zhao,Yusheng Huang,Minyong Wen,Lingjun Wang,Zhongqi Yang

Heliyon 9:e19934 PubMed37809369

2023

BMP-7 modified exosomes derived from synovial mesenchymal stem cells attenuate osteoarthritis by M2 polarization of macrophages.

Applications

Unspecified application

Species

Unspecified reactive species

Weixue Sun,Shaozheng Qu,Mingxia Ji,Yanli Sun,Baiqiang Hu

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

FITC Anti-CD206 抗体 [15-2]

FITC Anti-CD206 antibody [15-2]

Flow Cytometry - FITC Anti-CD206 antibody [15-2] (AB270647)

Flow Cytometry - FITC Anti-CD206 antibody [15-2] (AB270647)

Flow Cytometry - FITC Anti-CD206 antibody [15-2] (AB270647)

関連する標識済み抗体及び組成の異なる製品 (1)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

軽鎖のタイプ

標識

励起波長/蛍光波長

キャリアフリー

交差種

アプリケーション

免疫原

組合せ製品

Assay Kits

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (16)

Abcam product promise