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FITC Anti-LAMP1 抗体 [1D4B] (ab24871)

Submit a review Q&A (2)References (6)

Key features and details

  • FITC Rat monoclonal [1D4B] to LAMP1
  • Suitable for: Electron Microscopy, IHC-Fr, IP, WB, Flow Cyt
  • Reacts with: Mouse
  • Conjugation: FITC. Ex: 493nm, Em: 528nm
  • Isotype: IgG2a

Conjugates logo Related conjugates and formulations

Unconjugated

製品の概要

  • 製品名

    FITC Anti-LAMP1 antibody [1D4B]
    LAMP1 一次抗体 製品一覧

  • 製品の詳細

    FITC Rat monoclonal [1D4B] to LAMP1

  • 由来種

    Rat

  • 標識

    FITC. Ex: 493nm, Em: 528nm

  • 特異性

    This antibody is specific to murine CD107a/LAMP1 (Mr 110-140 kDa with a core protein of Mr ~40 kDa).

  • アプリケーション

    適用あり: Electron Microscopy, IHC-Fr, IP, WB, Flow Cytmore details

  • 種交差性

    交差種: Mouse

  • 免疫原

    Tissue, cells or virus corresponding to Mouse LAMP1. Plasma membrane fraction of mouse embryo NIH/3T3 cell line

  • 特記事項

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

アプリケーション

The Abpromise guarantee

Abpromise保証は、 次のテスト済みアプリケーションにおけるab24871の使用に適用されます

アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

アプリケーション Abreviews 特記事項
Electron Microscopy
Use at an assay dependent concentration.
IHC-Fr
Use at an assay dependent concentration.
IP
Use at an assay dependent concentration.
WB
Use at an assay dependent concentration. Predicted molecular weight: 45 kDa.
Flow Cyt
Use 1µg for 106 cells.

ab18446 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.
特記事項
Electron Microscopy
Use at an assay dependent concentration.
IHC-Fr
Use at an assay dependent concentration.
IP
Use at an assay dependent concentration.
WB
Use at an assay dependent concentration. Predicted molecular weight: 45 kDa.
Flow Cyt
Use 1µg for 106 cells.

ab18446 - Rat monoclonal IgG2a, is suitable for use as an isotype control with this antibody.

ターゲット情報

  • 機能

    Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.

  • 配列類似性

    Belongs to the LAMP family.

  • 翻訳後修飾

    O- and N-glycosylated; some of the 18 N-linked glycans are polylactosaminoglycans.

  • 細胞内局在

    Cell membrane. Endosome membrane. Lysosome membrane. This protein shuttles between lysosomes, endosomes, and the plasma membrane.
  • Information by UniProt

  • 参照データベース

    • 別名

      • CD107 antigen like family member A antibody
      • CD107 antigen-like family member A antibody
      • CD107a antibody
      • CD107a antigen antibody
      • LAMP 1 antibody
      • LAMP-1 antibody
      • LAMP1 antibody
      • LAMP1_HUMAN antibody
      • LAMPA antibody
      • LGP120 antibody
      • lgpA antibody
      • Lysosomal membrane glycoprotein 120KD antibody
      • Lysosomal Associated Membrane Protein 1 antibody
      • Lysosome associated membrane glycoprotein 1 antibody
      • Lysosome-associated membrane glycoprotein 1 antibody
      • Lysosome-associated membrane protein 1 antibody
      • OTTHUMP00000040663 antibody
      see all

    参考文献 (6)

    ab24871 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

    ab24871 は 6 報の論文で使用されています。

    • Triscott J  et al. PI5P4Kα supports prostate cancer metabolism and exposes a survival vulnerability during androgen receptor inhibition. Sci Adv 9:eade8641 (2023). PubMed: 36724278
    • Robinet P  et al. Quantitative trait locus mapping identifies the Gpnmb gene as a modifier of mouse macrophage lysosome function. Sci Rep 11:10249 (2021). PubMed: 33986446
    • Li L  et al. Forkhead box O3 (FoxO3) regulates kidney tubular autophagy following urinary tract obstruction. J Biol Chem 292:13774-13783 (2017). PubMed: 28705935
    • Harper MT  et al. Absence of platelet phenotype in mice lacking the motor protein myosin Va. PLoS One 8:e53239 (2013). PubMed: 23349704
    • Rich DR & Clark AL Chondrocyte primary cilia shorten in response to osmotic challenge and are sites for endocytosis. Osteoarthritis Cartilage 20:923-30 (2012). PubMed: 22554793
    • Buckley JM  et al. Increased susceptibility of ST2-deficient mice to polymicrobial sepsis is associated with an impaired bactericidal function. J Immunol 187:4293-9 (2011). Flow Cyt ; Mouse . PubMed: 21911606

    レビューと Q&A

    Show All レビュー Q&A
    レビューを送る 質問を送る

    1-2 of 2 Abreviews or Q&A

    Question

    Is product Anti-LAMP1 antibody [1D4B] (FITC) (ab24871) suitable for use in IHC-P applications?

    Read More
    Answer

    Unfortunately, we have not yet tested suitability of product Anti-LAMP1 antibody [1D4B] (FITC) (ab24871) for use in IHC-P applications. As such, use of this Ab in IHC-P applications is not yet covered by our Abpromise Guarantee.

    However, should you wish to test this Ab in an as-yet un-tested species or application, it may qualify for our Abtrial Testing Program.

    Read More

    Question

    Can you provide any references for use of product Anti-LAMP1 antibody [1D4B] (FITC) (ab24871) in Electron Microscopy applications?

    Read More
    Answer

    Unfortunately, we do not yet have any information on publications using product Anti-LAMP1 antibody [1D4B] (FITC) (ab24871) in Electron Microscopy applications.

    However, the following publication cites use of clone [1D4B] in Electron Microscopy experiments: The targeting of Lamp1 to lysosomes is dependent on the spacing of its cytoplasmic tail tyrosine sorting motif relative to the membrane (PMID: 8647888).

    Per the Materials and Methods: this report references use of frozen murine L cells, fixed in 1% glutaraldehyde (in HEPES saline) and infiltrated in PVP/sucrose; sections were probed with clone 1D4B followed by goat anti-rat IgG conjugated to 6nm gold.

    Read More

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