AB30486

FITC Anti-Integrin alpha 2 抗体 [AK7]

Name: FITC Anti-Integrin alpha 2 抗体 [AK7] (ab30486) | Abcam
Brand: Abcam Limited
SKU: AB30486
Price: 76000 JPY
Availability: InStock

FITC Anti-Integrin alpha 2 antibody [AK7]

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(4 Publications)

Mouse Monoclonal Integrin alpha 2 antibody - conjugated to FITC. Suitable for Flow Cyt and reacts with Human, Monkey samples. Cited in 4 publications.

別名を表示する

CD49b, CD49B, ITGA2, Integrin alpha-2, CD49 antigen-like family member B, Collagen receptor, Platelet membrane glycoprotein Ia, VLA-2 subunit alpha, GPIa

1 Images

Flow Cytometry - FITC Anti-Integrin alpha 2 antibody [AK7] (AB30486)

Flow Cyt

Unknown

Flow Cytometry - FITC Anti-Integrin alpha 2 antibody [AK7] (AB30486)

Flow cytometric analysis of human peripheral blood platlets with 10μl for 10⁶ cells of anti human CD49b FITC conjugated (ab30486).

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

AK7

アイソタイプ

IgG1

標識

FITC

励起波長/蛍光波長

Ex: 495nm, Em: 519nm

キャリアフリー

交差種

Human, Monkey

アプリケーション

Flow Cyt

applications

特異性

ab30486 recognises the integrin alpha 2 subunit, which is a 160kD glycoprotein that non covalently associates with the 130kD integrin beta 1 subunit (CD29) to form the VLA2 complex.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/1 - 1/5", "FlowCyt-species-notes": "<p><a href='/products/primary-antibodies/fitc-mouse-igg1-b11-6-isotype-control-ab91356'>ab91356</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>" }, "Monkey": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/1 - 1/5", "FlowCyt-species-notes": "<p><a href='/products/primary-antibodies/fitc-mouse-igg1-b11-6-isotype-control-ab91356'>ab91356</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein G

バッファー組成

pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS, 1% BSA

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

+4°C

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Integrin alpha 2 also known as CD49b ITGA2 and A2 is a protein that functions as part of the integrin family. Integrins are transmembrane receptors that facilitate cell-extracellular matrix adhesion. Integrin alpha 2 has a molecular mass of approximately 130 kDa and is widely expressed in epithelial cells fibroblasts and platelets. This protein is important for mediating adhesion between cells and the extracellular matrix affecting cell signaling and behavior. Through this adhesion cells can communicate with their environment adjusting their functions accordingly.

Biological function summary

Integrin alpha 2 plays a significant role in cellular processes like migration and proliferation. It forms a heterodimer complex by pairing with the beta 1-integrin subunit contributing to its adhesive and signaling functions. This association enables the integrin alpha 2 complex to bind specific extracellular matrix components such as collagen and laminin. Through these interactions it regulates processes like wound healing and tissue remodeling and affects how cells respond to mechanical stress.

Pathways

Integrin alpha 2 is involved in major signaling routes that influence cell fate and movement. Notably it participates in the PI3K/AKT and MAPK pathways which are important for regulating cell growth and survival. It interacts with signaling proteins like focal adhesion kinase (FAK) and Src family kinases linking extracellular matrix changes to intracellular responses. These pathways help in transmitting signals that coordinate the cell's structural and functional adjustments in response to its surroundings.

Integrin alpha 2 has connections to cancer and fibrosis. In cancers its altered expression may contribute to tumor progression and metastasis often involving interactions with other integrins and matrix metalloproteinases that degrade extracellular components. In fibrosis excessive integrin alpha 2 activity can lead to abnormal tissue remodeling and scarring implicating its role alongside collagen-producing cells. Understanding these connections is vital for developing therapies targeting integrin-mediated pathways in these diseases.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix.. (Microbial infection) Integrin ITGA2 : ITGB1 acts as a receptor for Human rotavirus A.. (Microbial infection) Integrin ITGA2 : ITGB1 acts as a receptor for Human echoviruses 1 and 8.

See full target information ITGA2

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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Journal of cellular and molecular medicine 24:13853-13862 PubMed33124775

2020

The stiffness-controlled release of interleukin-6 by cardiac fibroblasts is dependent on integrin α2β1.

Applications

Unspecified application

Species

Unspecified reactive species

Małgorzata Gałdyszyńska,Justyna Bobrowska,Małgorzata Lekka,Paulina Radwańska,Lucyna Piera,Jacek Szymański,Jacek Drobnik

Radiation oncology (London, England) 7:59 PubMed22500976

2012

Cancer-associated fibroblasts from human NSCLC survive ablative doses of radiation but their invasive capacity is reduced.

Applications

Flow Cyt

Species

Human

Turid Hellevik,Ingvild Pettersen,Vivian Berg,Jan Olof Winberg,Bjørn T Moe,Kristian Bartnes,Ruth H Paulssen,Lill-Tove Busund,Roy Bremnes,Anthony Chalmers,Iñigo Martinez-Zubiaurre

Cell transplantation 21:175-89 PubMed21294955

2011

Autologous lung-derived mesenchymal stem cell transplantation in experimental emphysema.

Applications

Unspecified application

Species

Unspecified reactive species

Edward P Ingenito,Larry Tsai,Shankar Murthy,Shivraj Tyagi,Melissa Mazan,Andrew Hoffman

Journal of tissue engineering and regenerative medicine 4:259-72 PubMed20020503

2009

Design and testing of biological scaffolds for delivering reparative cells to target sites in the lung.

Applications

Unspecified application

Species

Unspecified reactive species

Edward P Ingenito,Elif Sen,Larry W Tsai,Shankar Murthy,Andrew Hoffman

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

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FITC Anti-Integrin alpha 2 抗体 [AK7]

FITC Anti-Integrin alpha 2 antibody [AK7]

Flow Cytometry - FITC Anti-Integrin alpha 2 antibody [AK7] (AB30486)

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Key facts

宿主種

クローン性

クローン番号

アイソタイプ

標識

励起波長/蛍光波長

キャリアフリー

交差種

アプリケーション

特異性

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存温度

長期保存温度

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (4)

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