AB34176

FITC Anti-Integrin alpha 1 抗体 [TS2/7]

Name: FITC Anti-Integrin alpha 1 抗体 [TS2/7] (ab34176) | Abcam
Brand: Abcam Limited
SKU: AB34176
Price: 23000 JPY
Availability: InStock

FITC Anti-Integrin alpha 1 antibody [TS2/7]

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(4 Publications)

Anti-Integrin alpha 1 antibody [TS2/7] conjugated to FITC - suitable for flow cytometry, and reacts with human samples. Clone [TS2/7] is a mouse monoclonal antibody cited in 48 publications.

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別名を表示する

CD49a, Integrin alpha-1, CD49 antigen-like family member A, Laminin and collagen receptor, VLA-1, ITGA1

1 Images

Flow Cytometry - FITC Anti-Integrin alpha 1 antibody [TS2/7] (AB34176)

Flow Cyt

Supplier Data

Flow Cytometry - FITC Anti-Integrin alpha 1 antibody [TS2/7] (AB34176)

Flow Cytometry analysis of HeLa cells labeling Integrin alpha 1 with ab34176.

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

TS2/7

アイソタイプ

IgG1

標識

FITC

励起波長/蛍光波長

Ex: 495nm, Em: 519nm

キャリアフリー

交差種

Human

アプリケーション

Flow Cyt

applications

免疫原

Cell preparation containing ITGA1 protein. The exact immunogen used to generate this antibody is proprietary information.

P56199

特異性

This antibody recognises the human alpha 1 integrin subunit.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "1/1 - 1/5", "FlowCyt-species-notes": "<p><a href='/products/primary-antibodies/fitc-mouse-igg1-b11-6-isotype-control-ab91356'>ab91356</a> - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody.</p>" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein G

精製に関する特記事項

Purified IgG prepared by affinity chromatography on Protein G from tissue culture supernatant

バッファー組成

pH: 7.4 Preservative: 0.09% Sodium azide Constituents: PBS, 1% BSA

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

+4°C

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Integrin alpha 1 also called CD49a is a protein that functions as a mechanical link between cells and the extracellular matrix. It is part of the integrin protein family and partners with beta 1 integrin to form the integrin alpha 1 beta 1 complex. This protein is a heterodimer and weighs approximately 180 kDa. The integrin alpha 1 is expressed in various tissues including the dermis cartilage and the immune system especially on activated T cells and natural killer cells.

Biological function summary

Integrin alpha 1 beta 1 mediates cell adhesion and migration. It plays an important role in collagen binding influencing various cellular processes like proliferation and differentiation. Integrin alpha 1 forms a complex with ligand molecules notably collagen which assists in remodeling the extracellular matrix. This activity contributes to the development and repair of tissues offering structural support and pathways for cell signaling events.

Pathways

Integrin alpha 1 engages in the MAPK signaling pathway and regulation of the TGF-beta signaling cascade. By mediating interactions between cells and their environment it influences downstream signaling and gene expression. Integrins including integrin alpha 1 have roles in pathways related to cellular stress responses and signal modulation interacting with proteins such as fibronectin within these processes.

Integrin alpha 1 has been linked to fibrosis and chronic inflammatory diseases. By modulating matrix-related signals it influences the pathology of fibrosis through upregulation of matrix metalloproteinases. In chronic inflammatory diseases its interaction with collagen and other matrix proteins can affect immune cell trafficking and signaling. Understanding these connections helps in exploring potential therapeutic targets and interventions.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth.

See full target information ITGA1

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文献 (4)

Recent publications for all applications. Explore the full list and refine your search

Nature communications 16:6870 PubMed40715114

2025

Mammalian cells measure the extracellular matrix area and respond through switching the adhesion state.

Applications

Unspecified application

Species

Unspecified reactive species

Xiaole Wang,Pengli Wang,Lihang Zhang,Tianyu Xu,Seungkuk Ahn,Upnishad Sharma,Han Yu,Nico Strohmeyer,Daniel J Müller

Antioxidants (Basel, Switzerland) 11: PubMed36139739

2022

AMPK-Nrf2 Signaling Pathway in Phrenic Motoneurons following Cervical Spinal Cord Injury.

Applications

Unspecified application

Species

Unspecified reactive species

Pauline Michel-Flutot,Laurie Efthimiadi,Lynda Djerbal,Therese B Deramaudt,Marcel Bonay,Stéphane Vinit

Annals of the rheumatic diseases 69:270-5 PubMed19279017

2009

Transforming growth factor beta1 and laminin-111 cooperate in the induction of interleukin-16 expression in synovial fibroblasts from patients with rheumatoid arthritis.

Applications

Unspecified application

Species

Unspecified reactive species

K Warstat,M Hoberg,M Rudert,S Tsui,T Pap,B Angres,M Essl,T J Smith,W W Cruikshank,G Klein,S Gay,W K Aicher

The Journal of biological chemistry 280:13848-57 PubMed15647274

2005

A streptococcal collagen-like protein interacts with the alpha2beta1 integrin and induces intracellular signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Joseph O Humtsoe,Jiyeun K Kim,Yi Xu,Douglas R Keene,Magnus Höök,Slawomir Lukomski,Kishore K Wary

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

FITC Anti-Integrin alpha 1 抗体 [TS2/7]

FITC Anti-Integrin alpha 1 antibody [TS2/7]

Flow Cytometry - FITC Anti-Integrin alpha 1 antibody [TS2/7] (AB34176)

関連する標識済み抗体及び組成の異なる製品 (1)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

標識

励起波長/蛍光波長

キャリアフリー

交差種

アプリケーション

免疫原

特異性

代替製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

精製に関する特記事項

バッファー組成

出荷温度

短期保存温度

長期保存温度

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (4)

Abcam product promise