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AB239245

FITC Anti-CD89 抗体 [A59]

FITC Anti-CD89 antibody [A59]

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Mouse Monoclonal CD89 antibody - conjugated to FITC. Suitable for Flow Cyt and reacts with Human samples. Immunogen corresponding to Cell preparation containing FCAR protein.

別名を表示する

CD89, FCAR, Immunoglobulin alpha Fc receptor, IgA Fc receptor

1 Images
Flow Cytometry - FITC Anti-CD89 antibody [A59] (AB239245)
  • Flow Cyt

Supplier Data

Flow Cytometry - FITC Anti-CD89 antibody [A59] (AB239245)

Flow cytometric analysis of human peripheral blood labeling CD89 with ab239245. Surface staining. Gated on leukocytes.

関連する標識済み抗体及び組成の異なる製品 (1)

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

A59

アイソタイプ

IgG1

標識

FITC

励起波長/蛍光波長

Ex: 495nm, Em: 519nm

キャリアフリー

No

交差種

Human

アプリケーション

Flow Cyt

applications

免疫原

Cell preparation containing FCAR protein. The exact immunogen used to generate this antibody is proprietary information.

P24071

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "FlowCyt" : {"fullname" : "Flow Cytometry", "shortname":"Flow Cyt"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "FlowCyt-species-checked": "testedAndGuaranteed", "FlowCyt-species-dilution-info": "4 µL for 10^6 Cells", "FlowCyt-species-notes": "<p>(or 100 μl of whole blood).</p>" }, "Primates": { "FlowCyt-species-checked": "predicted", "FlowCyt-species-dilution-info": "", "FlowCyt-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Size-exclusion chromatography
精製に関する特記事項
Purified antibody is conjugated with Fluorescein isothiocyanate (FITC) under optimum conditions. The reagent is free of unconjugated FITC and adjusted for direct use. No reconstitution is necessary.
バッファー組成
pH: 7.4 Preservative: 0.0975% Sodium azide Constituents: PBS
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
+4°C
保管に関する情報
Store in the dark
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

CD89 also known as the Fc alpha receptor (FcαR) is a protein receptor with a molecular mass of approximately 55 to 75 kDa. It is encoded by the FCAR gene and predominantly expressed on myeloid cells such as neutrophils eosinophils monocytes and some macrophages. CD89 acts as an important component of the immune system by binding to the Fc region of immunoglobulin A (IgA) facilitating various immune responses. This receptor mediates diverse immune functions by activating cellular responses upon IgA ligand binding.
Biological function summary

CD89 plays an important role in regulating immune surveillance and response. It associates with the gamma chain of the Fc receptor complex which is necessary for its signaling ability. The binding of IgA to CD89 triggers various processes including phagocytosis antibody-dependent cellular cytotoxicity (ADCC) and the release of pro-inflammatory cytokines. These processes are fundamental for host defense against pathogens particularly those entering through mucosal surfaces where IgA is typically abundant.

Pathways

CD89 is part of the immune effector pathway and participates actively in the immunoregulatory signaling cascade. One significant pathway is the IgA-mediated immune response pathway where CD89 cooperates with other Fc receptors and integrins to clear infections. Additionally its interaction with the complement system enhances opsonization and pathogen elimination. Related proteins in these pathways include other Fc receptors like FcγR which share similar signaling mechanisms and immune functions.

CD89 is associated with conditions involving dysregulated immune responses or infections. For example it is implicated in IgA nephropathy where abnormal IgA deposits in the kidneys may trigger inflammation through CD89-mediated pathways. Furthermore alterations in CD89 expression or function have been studied in the context of inflammatory bowel disease (IBD) illustrating the receptor's role in aberrant immune responses. The target’s interaction with proteins such as IgA and complement C3 provides insight into its involvement in these pathological conditions.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production.
See full target information FCAR
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Abcam product promise

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保証に関する詳細については利用規約をご確認ください。
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