FITC Anti-CD11c 抗体 [BU15] (ab22540)
Key features and details
- FITC Mouse monoclonal [BU15] to CD11c
- Suitable for: Flow Cyt
- Reacts with: Dog, Human, Cynomolgus monkey
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG1
製品の概要
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製品名
FITC Anti-CD11c antibody [BU15]
CD11c 一次抗体 製品一覧 -
製品の詳細
FITC Mouse monoclonal [BU15] to CD11c -
由来種
Mouse -
標識
FITC. Ex: 493nm, Em: 528nm -
特異性
This antibody recognises the integrin alphax subunit, a 150kD glycoprotein expressed by macrophages, monocytes, granulocytes and NK cells. The antigen is also expressed by hairy cell leukaemia cells. Ligands for CD11c are ICAM 1, iC3b, and fibrinogen. The molecule has a role in mediating adherence of granulocytes and monocytes to endothelium and fibrinogen. -
アプリケーション
適用あり: Flow Cytmore details -
種交差性
交差種: Dog, Human, Cynomolgus monkey -
免疫原
The details of the immunogen for this antibody are not available.
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. -
バッファー
Preservative: 0.09% Sodium azide
Constituent: 1% BSA -
Concentration information loading... -
精製度
Protein G purified -
ポリ/モノ
モノクローナル -
クローン名
BU15 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Alternative Versions
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab22540の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| Flow Cyt |
1/1 - 1/10.
ab91356 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. Use 10µl of working dilution for 106 cells. |
| 特記事項 |
|---|
|
Flow Cyt
1/1 - 1/10. ab91356 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. Use 10µl of working dilution for 106 cells. |
ターゲット情報
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機能
Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis. -
組織特異性
Predominantly expressed in monocytes and granulocytes. -
配列類似性
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain. -
ドメイン
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. -
細胞内局在
Membrane. - Information by UniProt
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参照データベース
- Entrez Gene: 3687 Human
- Omim: 151510 Human
- SwissProt: P20702 Human
- Unigene: 248472 Human
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別名
- 95 alpha chain antibody
- 95 antibody
- CD 11c antibody
see all
データシートおよび資料
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Datasheet download
参考文献 (4)
ab22540 は 4 報の論文で使用されています。
- Hopfensperger K et al. Convergent Evolution of HLA-C Downmodulation in HIV-1 and HIV-2. mBio 11:N/A (2020). PubMed: 32665270
- Langer S et al. HIV-1 Vpu is a potent transcriptional suppressor of NF-?B-elicited antiviral immune responses. Elife 8:N/A (2019). PubMed: 30717826
- Braun E et al. Guanylate-Binding Proteins 2 and 5 Exert Broad Antiviral Activity by Inhibiting Furin-Mediated Processing of Viral Envelope Proteins. Cell Rep 27:2092-2104.e10 (2019). PubMed: 31091448
- Rezzonico R et al. Ligation of CD11b and CD11c beta(2) integrins by antibodies or soluble CD23 induces macrophage inflammatory protein 1alpha (MIP-1alpha) and MIP-1beta production in primary human monocytes through a pathway dependent on nuclear factor-kappaB. Blood 97:2932-40 (2001). PubMed: 11342414
