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FITC Anti-CD11b 抗体 [ICRF44] (ab176541)

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Flow Cytometry - FITC Anti-CD11b antibody [ICRF44] (ab176541)

    Key features and details

    • FITC Mouse monoclonal [ICRF44] to CD11b
    • Suitable for: Flow Cyt
    • Reacts with: Human
    • Conjugation: FITC. Ex: 493nm, Em: 528nm
    • Isotype: IgG1

    Conjugates logo Related conjugates and formulations

    Alexa Fluor® 488 APC APC/Cy7® Biotin FITC PE/Cy7® PE/Cy7® Unconjugated

    製品の概要

    • 製品名

      FITC Anti-CD11b antibody [ICRF44]
      CD11b 一次抗体 製品一覧

    • 製品の詳細

      FITC Mouse monoclonal [ICRF44] to CD11b

    • 由来種

      Mouse

    • 標識

      FITC. Ex: 493nm, Em: 528nm

    • アプリケーション

      適用あり: Flow Cytmore details

    • 種交差性

      交差種: Human

    • 免疫原

      Tissue, cells or virus corresponding to Human CD11b. Rheumatoid synovial cells and Human monocytes.

    • 特記事項

      The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

      If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

    製品の特性

    アプリケーション

    The Abpromise guarantee

    Abpromise保証は、 次のテスト済みアプリケーションにおけるab176541の使用に適用されます

    アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

    アプリケーション Abreviews 特記事項
    Flow Cyt
    Use at an assay dependent concentration.
    特記事項
    Flow Cyt
    Use at an assay dependent concentration.

    ターゲット情報

    • 機能

      Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.

    • 組織特異性

      Predominantly expressed in monocytes and granulocytes.

    • 関連疾患

      Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.

    • 配列類似性

      Belongs to the integrin alpha chain family.
      Contains 7 FG-GAP repeats.
      Contains 1 VWFA domain.

    • ドメイン

      The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage.

    • 細胞内局在

      Membrane.
    • Information by UniProt

    • 参照データベース

      • 別名

        • antigen CD11b (p170) antibody
        • Antigen CD11b p170 antibody
        • CD11 antigen like family member B antibody
        • CD11 antigen-like family member B antibody
        • CD11b antibody
        • CD11b/CD18 antibody
        • CD49d antibody
        • Cell surface glycoprotein MAC-1 subunit alpha antibody
        • Complement component 3 receptor 3 subunit antibody
        • Complement Component Receptor 3 Alpha antibody
        • Complement receptor type 3 antibody
        • Complement receptor type 3, alpha subunit antibody
        • CR 3 alpha chain (CR3A) antibody
        • CR 3 alpha chain antibody
        • CR-3 alpha chain antibody
        • CR3 antibody
        • CR3A antibody
        • F730045J24Rik antibody
        • Integrin Alpha M antibody
        • Integrin alpha M chain antibody
        • Integrin alpha-M antibody
        • Integrin beta 2 alpha subunit antibody
        • Integrin subunit alpha M antibody
        • integrin, alpha M (complement component 3 receptor 3 subunit) antibody
        • ITAM_HUMAN antibody
        • ITGAM antibody
        • Leukocyte adhesion receptor MO1 antibody
        • Ly-40 antibody
        • MAC 1 antibody
        • Mac-1a antibody
        • MAC1 antibody
        • Mac1, alpha subunit antibody
        • MAC1A antibody
        • Macrophage antigen alpha polypeptide antibody
        • MGC117044 antibody
        • Mo1 antibody
        • Mo1, alpha subunit antibody
        • MO1A antibody
        • Neutrophil adherence receptor alpha M subunit antibody
        • Neutrophil adherence receptor antibody
        • SLEB6 antibody
        see all

      画像

      • Flow Cytometry - FITC Anti-CD11b antibody [ICRF44] (ab176541)
        Flow Cytometry - FITC Anti-CD11b antibody [ICRF44] (ab176541)

        Flow cytometry analysis showing Human peripheral blood monocytes stained with ab176541 (solid line). The isotype control was FITC Mouse IgG1 (dashed line).

         

      参考文献 (1)

      ab176541 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

      ab176541 は 1 報の論文で使用されています。

      • Yoshimori M  et al. Interferon-γ Produced by EBV-Positive Neoplastic NK-Cells Induces Differentiation into Macrophages and Procoagulant Activity of Monocytes, Which Leads to HLH. Cancers (Basel) 13:N/A (2021). PubMed: 34680246

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