FITC Anti-CD11b 抗体 [2F4/11] (ab34444)
Key features and details
- FITC Mouse monoclonal [2F4/11] to CD11b
- Suitable for: Flow Cyt
- Reacts with: Pig
- Conjugation: FITC. Ex: 493nm, Em: 528nm
- Isotype: IgG1
製品の概要
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製品名
FITC Anti-CD11b antibody [2F4/11]
CD11b 一次抗体 製品一覧 -
製品の詳細
FITC Mouse monoclonal [2F4/11] to CD11b -
由来種
Mouse -
標識
FITC. Ex: 493nm, Em: 528nm -
特異性
ab34444 is expressed on granulocytes, monocytes and alveolar macrophages, but not on lymphocytes, eythrocytes or platelets. -
アプリケーション
適用あり: Flow Cytmore details -
種交差性
交差種: Pig -
免疫原
Tissue, cells or virus corresponding to Pig CD11b. Immunogen is Porcine alveolar macrophages.
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ポジティブ･コントロール
- CD11b marker is expressed on granulocytes, monocytes and alveolar macrophages.
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特記事項
ab34444 is reported to block phagocytosis of complement-opsonised zymosan particles by polymononuclear granulocytes and alveolar macrophages.
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製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C or -80°C. Avoid freeze / thaw cycle. Store In the Dark. -
バッファー
pH: 7.40
Preservative: 0.09% Sodium azide
Constituent: PBS -
Concentration information loading... -
精製度
Protein G purified -
一次抗体 備考
ab34444 is reported to block phagocytosis of complement-opsonised zymosan particles by polymononuclear granulocytes and alveolar macrophages. -
ポリ/モノ
モノクローナル -
クローン名
2F4/11 -
ミエローマ
x63-Ag8.653 -
アイソタイプ
IgG1 -
研究分野
関連製品
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab34444の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| Flow Cyt |
Use at an assay dependent concentration.
Neat - 1/10. Use 10ul of the suggested working dilution to 1x10^6 cells in 100ul. ab91356 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
| 特記事項 |
|---|
|
Flow Cyt
Use at an assay dependent concentration. Neat - 1/10. Use 10ul of the suggested working dilution to 1x10^6 cells in 100ul. ab91356 - Mouse monoclonal IgG1, is suitable for use as an isotype control with this antibody. |
ターゲット情報
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機能
Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. -
組織特異性
Predominantly expressed in monocytes and granulocytes. -
関連疾患
Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. -
配列類似性
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain. -
ドメイン
The integrin I-domain (insert) is a VWFA domain. Integrins with I-domains do not undergo protease cleavage. -
細胞内局在
Membrane. - Information by UniProt
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別名
- antigen CD11b (p170) antibody
- Antigen CD11b p170 antibody
- CD11 antigen like family member B antibody
see all
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab34444 は論文での使用が確認できていません。