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AB51217

Anti-Filamin A 抗体

Anti-Filamin A antibody

4

(8 Reviews)

|

(16 Publications)

Rabbit Polyclonal Filamin A antibody. Suitable for WB and reacts with Human samples. Cited in 16 publications. Immunogen corresponding to Synthetic Peptide within Human FLNA.

別名を表示する

FLN, FLN1, FLNA, Filamin-A, FLN-A, Actin-binding protein 280, Alpha-filamin, Endothelial actin-binding protein, Filamin-1, Non-muscle filamin, ABP-280

1 Images
Western blot - Anti-Filamin A antibody (AB51217)
  • WB

Unknown

Western blot - Anti-Filamin A antibody (AB51217)

All lanes:

Western blot - Anti-Filamin A antibody (ab51217) at 1/300 dilution

Lane 1:

Extracts of 293 cells treated with EGF (200ng/ml, 5mins).

Lane 2:

Extracts of 293 cells treated with EGF (200ng/ml, 5mins) and peptide.

Predicted band size: 281 kDa

Observed band size: 281 kDa

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Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB

applications

免疫原

Synthetic Peptide within Human FLNA. The exact immunogen used to generate this antibody is proprietary information.

P21333

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/300 - 1/1000", "WB-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
精製に関する特記事項
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
保管に関する情報
Stable for 12 months at -20°C
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Promotes orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton and serves as a scaffold for a wide range of cytoplasmic signaling proteins. Interaction with FLNB may allow neuroblast migration from the ventricular zone into the cortical plate. Tethers cell surface-localized furin, modulates its rate of internalization and directs its intracellular trafficking (By similarity). Involved in ciliogenesis. Plays a role in cell-cell contacts and adherens junctions during the development of blood vessels, heart and brain organs. Plays a role in platelets morphology through interaction with SYK that regulates ITAM- and ITAM-like-containing receptor signaling, resulting in by platelet cytoskeleton organization maintenance (By similarity). During the axon guidance process, required for growth cone collapse induced by SEMA3A-mediated stimulation of neurons (PubMed : 25358863).
See full target information FLNA
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文献 (16)

Recent publications for all applications. Explore the full list and refine your search

The Journal of neuroscience : the official journal of the Society for Neuroscience 44: PubMed39164108

2024

Reducing Filamin A Restores Cortical Synaptic Connectivity and Early Social Communication Following Cellular Mosaicism in Autism Spectrum Disorder Pathways.

Applications

Unspecified application

Species

Unspecified reactive species

Matthew S Binder,Iris Escobar,Youfen Xu,Aidan M Sokolov,Longbo Zhang,Angélique Bordey

Journal of cellular and molecular medicine 27:2228-2238 PubMed37415307

2023

Over-expression of Dyrk1A affects bleeding by modulating plasma fibronectin and fibrinogen level in mice.

Applications

Unspecified application

Species

Unspecified reactive species

Guillaume Postic,Jean Solarz,Cécile Loubière,Janany Kandiah,Jaysen Sawmynaden,Frederic Adam,Marie Vilaire,Thibaut Léger,Jean-Michel Camadro,Daniella Balduino Victorino,Marie-Claude Potier,Eric Bun,Gautier Moroy,Alexandre Kauskot,Olivier Christophe,Nathalie Janel

Frontiers in cellular neuroscience 16:859882 PubMed35602553

2022

Stiffening of Circumferential F-Actin Bands Correlates With Regenerative Failure and May Act as a Biomechanical Brake in the Mammalian Inner Ear.

Applications

Unspecified application

Species

Unspecified reactive species

Mark A Rudolf,Anna Andreeva,Christina E Kim,Anthony C-J DeNovio,Antoan N Koshar,Wendy Baker,Alexander X Cartagena-Rivera,Jeffrey T Corwin

International journal of molecular sciences 23: PubMed35269714

2022

Quantitative Proteomics Reveals Molecular Network Driving Stromal Cell Differentiation: Implications for Corneal Wound Healing.

Applications

Unspecified application

Species

Unspecified reactive species

Krishnatej Nishtala,Trailokyanath Panigrahi,Rohit Shetty,Dhanananajay Kumar,Pooja Khamar,Rajiv R Mohan,Vrushali Deshpande,Arkasubhra Ghosh

Small (Weinheim an der Bergstrasse, Germany) 16:e2000012 PubMed32239653

2020

Anti-Atherogenic Effect of Stem Cell Nanovesicles Targeting Disturbed Flow Sites.

Applications

Unspecified application

Species

Unspecified reactive species

Jeong-Kee Yoon,Dae-Hyun Kim,Mi-Lan Kang,Hyeon-Ki Jang,Hyun-Ji Park,Jung Bok Lee,Se Won Yi,Hye-Seon Kim,Sewoom Baek,Dan Bi Park,Jin You,Seong-Deok Lee,Yoshitaka Sei,Song Ih Ahn,Young Min Shin,Chang Soo Kim,Sangsu Bae,YongTae Kim,Hak-Joon Sung

Oncology reports 41:3424-3434 PubMed31002357

2019

Overexpression of calpain‑1 predicts poor outcome in patients with colorectal cancer and promotes tumor cell progression associated with downregulation of FLNA.

Applications

Unspecified application

Species

Unspecified reactive species

Changzhao Xu,Xiaoxiao Yu,Yuesheng Zhu,Zhenzhai Cai,Lingmin Yu,Ying Lin,Hejie Yu,Zhanxiong Xue,Lingling Zhou

Integrative biology : quantitative biosciences from nano to macro 8:1049-1058 PubMed27723854

2016

High content image analysis of focal adhesion-dependent mechanosensitive stem cell differentiation.

Applications

Unspecified application

Species

Unspecified reactive species

Andrew W Holle,Alistair J McIntyre,Jared Kehe,Piyumi Wijesekara,Jennifer L Young,Ludovic G Vincent,Adam J Engler

Neuroscience letters 629:15-18 PubMed27345385

2016

Tsc1 haploinsufficiency is sufficient to increase dendritic patterning and Filamin A levels.

Applications

Unspecified application

Species

Unspecified reactive species

Longbo Zhang,Tianxiang Huang,Angélique Bordey

Nature communications 7:11642 PubMed27189435

2016

Context-dependent switch in chemo/mechanotransduction via multilevel crosstalk among cytoskeleton-regulated MRTF and TAZ and TGFβ-regulated Smad3.

Applications

Unspecified application

Species

Unspecified reactive species

Pam Speight,Michael Kofler,Katalin Szászi,András Kapus

ACS nano 9:4435-46 PubMed25768046

2015

Phage-display-guided nanocarrier targeting to atheroprone vasculature.

Applications

Unspecified application

Species

Unspecified reactive species

Lucas H Hofmeister,Sue Hyun Lee,Allison E Norlander,Kim Ramil C Montaniel,Wei Chen,David G Harrison,Hak-Joon Sung
View all publications
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