AB108616

Anti-Fibrinogen alpha chain 抗体 [EPR2918]

Anti-Fibrinogen alpha chain antibody [EPR2918]

RabMAb
Recombinant
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(5 Publications)

Rabbit Recombinant Monoclonal Fibrinogen alpha chain antibody. Suitable for WB and reacts with Human samples. Cited in 5 publications.

別名を表示する

Fibrinogen alpha chain, FGA

2 Images

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Western blot - Anti-Fibrinogen alpha chain antibody [EPR2918] (AB108616)

Blocking and diluting buffer : 5% NFDM/TBST

All lanes:

Western blot - Anti-Fibrinogen alpha chain antibody [EPR2918] (ab108616) at 0.9 µg/mL

All lanes:

Human plasma lysates at 15 µg

Secondary

All lanes:

Goat Anti-Rabbit IgG (HRP) with minimal cross-reactivity with human IgG at 1/2000 dilution

Predicted band size: 95 kDa

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Western blot - Anti-Fibrinogen alpha chain antibody [EPR2918] (AB108616)

All lanes:

Western blot - Anti-Fibrinogen alpha chain antibody [EPR2918] (ab108616) at 1/2000 dilution

Lane 1:

Human plasma lysates at 10 µg

Lane 2:

Human fetal liver lysates at 10 µg

Secondary

All lanes:

HRP labelled goat anti-rabbit at 1/2000 dilution

Predicted band size: 95 kDa

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Key facts

宿主種

Rabbit

クローン性

Monoclonal

クローン番号

EPR2918

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

applications

免疫原

The exact immunogen used to generate this antibody is proprietary information.

特異性

The immunogen is derived from isoform alpha-E, UniProt accession P02671-1, and the antibody is not expected to detect isoform alpha.

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "IP" : {"fullname" : "Immunoprecipitation", "shortname":"IP"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "IP-species-checked": "notRecommended", "IP-species-dilution-info": "", "IP-species-notes": "", "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/2000 - 1/10000", "WB-species-notes": "", "IHCP-species-checked": "notRecommended", "IHCP-species-dilution-info": "", "IHCP-species-notes": "" } } }

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製品の詳細

Species reactivity
Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species.
Please contact us for more information.

Patented technology
Our RabMAb^® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb^® patents.

What are the advantages of a recombinant monoclonal antibody?
This product is a recombinant monoclonal antibody, which offers several advantages including:

- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production

For more information, read more on recombinant antibodies.

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Protein A

バッファー組成

pH: 7.2 - 7.4 Preservative: 0.01% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine), 0.05% BSA

出荷温度

Conditional Ambient

短期保存温度

+4°C

長期保存温度

-20°C

保管に関する情報

Stable for 12 months at -20°C

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.

See full target information FGA

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文献 (5)

Recent publications for all applications. Explore the full list and refine your search

European journal of medical research 30:859 PubMed41013641

2025

RHBDD1 induces cell cycle arrest in TP53-mutant NSCLC cells by promoting endoplasmic reticulum-associated degradation of p53 and DNA-PKcs.

Applications

Unspecified application

Species

Unspecified reactive species

Yun Chen,Yang Wang,Shuai Shen,Libin Zhang,Jun Liu,Xiangyun Yan,Hao Peng,Zheyuan Xu

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 22:e00538 PubMed39904669

2025

Fibrinogen degradation products exacerbate alpha-synuclein aggregation by inhibiting autophagy via downregulation of Beclin1 in multiple system atrophy.

Applications

Unspecified application

Species

Unspecified reactive species

Huanzhu Liu,Ruoyang Yu,Muwei Zhang,Xiaoyan Zheng,Lizi Zhong,Wanlin Yang,Yuqi Luo,Zifeng Huang,Jialing Zheng,Hui Zhong,Xiaobo Wei,Wenhua Zheng,Yinghua Yu,Qing Wang

Frontiers in genetics 11:551065 PubMed33424913

2020

Integration of Transcriptome Resequencing and Quantitative Proteomics Analyses of Collagenase VII-Induced Intracerebral Hemorrhage in Mice.

Applications

Unspecified application

Species

Unspecified reactive species

Fang Cao,Yu Guo,Qiang Zhang,Yinchun Fan,Qian Liu,Jiancheng Song,Hua Zhong,Shengtao Yao

Proteomics. Clinical applications 14:e1900099 PubMed32677377

2020

Isoform 1 of Fibrinogen Alpha Chain Precursor is a Potential Biomarker for Steroid-Induced Osteonecrosis of the Femoral Head.

Applications

Unspecified application

Species

Unspecified reactive species

Liying Liu,Jidong Song,Jun Li,Na Huang,Juan Yang,Shugang Hu,Rui Ma,Wei Wang

Blood advances 4:2939-2949 PubMed32603423

2020

Dominant role of αIIbβ3 in platelet interactions with cross-linked fibrin fragment D-dimer.

Applications

Unspecified application

Species

Unspecified reactive species

Lorena Buitrago,Hina Zafar,Yixiao Zhang,Jihong Li,Thomas Walz,Barry S Coller

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-Fibrinogen alpha chain 抗体 [EPR2918]

Anti-Fibrinogen alpha chain antibody [EPR2918]

Western blot - Anti-Fibrinogen alpha chain antibody [EPR2918] (AB108616)

Western blot - Anti-Fibrinogen alpha chain antibody [EPR2918] (AB108616)

関連する標識済み抗体及び組成の異なる製品 (1)

Key facts

宿主種

クローン性

クローン番号

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

特異性

代替製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

組合せ製品

Assay Kits

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

製品の詳細

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存温度

長期保存温度

保管に関する情報

製品プロトコール

ターゲットの情報

文献 (5)

Abcam product promise