Anti-Fibrillin 2 抗体 (ab128026)
Key features and details
- Rabbit polyclonal to Fibrillin 2
- Suitable for: ELISA, IHC-P, ICC, IP, WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-Fibrillin 2 antibody
Fibrillin 2 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Fibrillin 2 -
由来種
Rabbit -
特異性
No cross-reactivity with Fibrillin 1. -
アプリケーション
適用あり: ELISA, IHC-P, ICC, IP, WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Cow -
免疫原
Recombinant fragment containing glycine-rich domain of exon 10 of Human Fibrillin 2.
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ポジティブ・コントロール
- Human Prostate, Extra Cellular tissue
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. -
バッファー
pH: 7.4
Constituents: 99% Whole serum, 1% PBS -
Concentration information loading...
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精製度
Whole antiserum -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
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Recombinant Protein
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab128026の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
アプリケーション | Abreviews | 特記事項 |
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ELISA |
Use at an assay dependent concentration.
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IHC-P |
Use at an assay dependent concentration.
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ICC |
Use at an assay dependent concentration.
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IP |
Use at an assay dependent concentration.
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WB |
Use at an assay dependent concentration.
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特記事項 |
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ELISA
Use at an assay dependent concentration. |
IHC-P
Use at an assay dependent concentration. |
ICC
Use at an assay dependent concentration. |
IP
Use at an assay dependent concentration. |
WB
Use at an assay dependent concentration. |
ターゲット情報
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機能
Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. -
関連疾患
Defects in FBN2 are the cause of congenital contractural arachnodactyly (CCA) [MIM:121050]; also known as Beals syndrome or distal arthrogryposis type 9 (DA9). CCA is a rare, autosomal dominant connective tissue disorder characterized by contractures, arachnodactyly, scoliosis, and crumpled ears. Phenotypically similar to Marfan syndrome, CCA does not affect the aorta and the eyes. -
配列類似性
Belongs to the fibrillin family.
Contains 47 EGF-like domains.
Contains 9 TB (TGF-beta binding) domains. -
細胞内局在
Secreted > extracellular space > extracellular matrix. - Information by UniProt
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参照データベース
- Entrez Gene: 281155 Cow
- Entrez Gene: 2201 Human
- Omim: 121050 Human
- SwissProt: P35556 Human
- Unigene: 519294 Human
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別名
- CCA antibody
- congenital contractural arachnodactyly (Marfanoid-like) antibody
- DA9 antibody
see all
プロトコール
データシートおよび資料
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Datasheet download
参考文献 (3)
ab128026 は 3 報の論文で使用されています。
- Williams JL et al. Defining the molecular signatures of human right heart failure. Life Sci 196:118-126 (2018). PubMed: 29366750
- Villain G et al. MAGP-1 and fibronectin control EGFL7 functions by driving its deposition into distinct endothelial extracellular matrix locations. FEBS J 285:4394-4412 (2018). PubMed: 30338930
- Gilpin SE et al. Fibrillin-2 and Tenascin-C bridge the age gap in lung epithelial regeneration. Biomaterials 140:212-219 (2017). PubMed: 28662401