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AB67681

Anti-FGD5 抗体

Anti-FGD5 antibody

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Mouse Polyclonal FGD5 antibody - Carrier free. Suitable for WB and reacts with Human samples.

別名を表示する

ZFYVE23, FGD5, Zinc finger FYVE domain-containing protein 23

1 Images
Western blot - Anti-FGD5 antibody (AB67681)
  • WB

Unknown

Western blot - Anti-FGD5 antibody (AB67681)

All lanes:

Western blot - Anti-FGD5 antibody (ab67681) at 1/500 dilution

Lane 1:

FGD5 transfected 293T cell lysate at 25 µg

Lane 2:

Non-transfected 293T cell lysate at 25 µg

Secondary

All lanes:

Goat Anti-Mouse IgG (H&L)-HRP Conjugate at 1/2500 dilution

Predicted band size: 160 kDa

Observed band size: 65 kDa

false

Key facts

宿主種

Mouse

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

Yes

交差種

Human

アプリケーション

WB

applications

免疫原

Recombinant Full Length Protein corresponding to Human FGD5.

Q6ZNL6

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein A
バッファー組成
pH: 7.4 Constituents: PBS
出荷温度
Blue Ice
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

FGD5 also known as Faciogenital Dysplasia 5 is a protein that functions mechanically as a Rho GTPase exchange factor. It has an approximate mass of 145 kilodaltons. FGD5 features an FYVE finger domain which is essential for its binding to phosphatidylinositol 3-phosphate. It is expressed significantly in endothelial cells suggesting a role in vascular development. Additionally FGD5 can be found in various tissues throughout the body highlighting its potential diverse functions.
Biological function summary

FGD5 contributes to cytoskeletal organization by activating the Rho family of GTPases which are important for cell shape and movement. The protein does not appear to be part of a larger protein complex but its interactions with the cytoskeleton suggest it plays an important role in endothelial cell function. These activities point to its involvement in angiogenesis and other vascular processes.

Pathways

FGD5 acts in the MAPK signaling pathway contributing to cellular responses triggered by external signals like growth factors. It is also linked to the VEGF pathway which is critical for blood vessel formation. Interactions with other proteins such as VEGFR2 and ERK1/2 enable FGD5 to regulate endothelial cell proliferation and migration thereby influencing vascular remodeling.

FGD5 has been implicated in cardiovascular diseases and cancer. Its role in blood vessel formation and maintenance associates it with pathological conditions where abnormal angiogenesis is a factor. FGD5 alterations can affect disease progression with possible links to the overexpression of proteins like VEGF and PDGF in cancer highlighting its importance in understanding these diseases.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.
See full target information FGD5
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