Anti-FBXO31 抗体 (ab68067)
Key features and details
- Mouse polyclonal to FBXO31
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
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製品名
Anti-FBXO31 antibody
FBXO31 一次抗体 製品一覧 -
製品の詳細
Mouse polyclonal to FBXO31 -
由来種
Mouse -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human -
免疫原
Recombinant full length protein within Human FBXO31 aa 1-400. The exact immunogen sequence used to generate this antibody is proprietary information. If additional detail on the immunogen is needed to determine the suitability of the antibody for your needs, please contact our Scientific Support team to discuss your requirements.
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ポジティブ･コントロール
- FBXO31 transfected mammalian cell lysate
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特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. -
バッファー
pH: 7.4
Constituent: PBS -
Concentration information loading... -
精製度
Protein A purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Compatible Secondaries
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab68067の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB | (1) |
1/500 - 1/1000. Predicted molecular weight: 66 kDa.
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| 特記事項 |
|---|
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WB
1/500 - 1/1000. Predicted molecular weight: 66 kDa. |
ターゲット情報
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機能
Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in G1 arrest following DNA damage. Specifically recognizes phosphorylated cyclin-D1 (CCND1), promoting its ubiquitination and degradation by the proteasome, resulting in G1 arrest. May act as a tumor suppressor. -
組織特異性
Highly expressed in brain. Expressed at moderate levels in most tissues, except bone marrow. -
パスウェイ
Protein modification; protein ubiquitination. -
配列類似性
Belongs to the FBXO31 family.
Contains 1 F-box domain. -
発生段階
Expression is cell-cycle regulated, and peaks at late G2 to early G1 phase (at protein level). -
翻訳後修飾
Phosphorylation at Ser-278 by ATM following gamma-irradiation results in its stabilization. - Information by UniProt
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参照データベース
- Entrez Gene: 79791 Human
- Omim: 609102 Human
- SwissProt: Q5XUX0 Human
- Unigene: 567582 Human
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別名
- DKFZp434B027 antibody
- DKFZp434J1815 antibody
- F box only protein 31 antibody
see all
画像
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Western blot - Anti-FBXO31 antibody (ab68067)All lanes : Anti-FBXO31 antibody (ab68067) at 1/500 dilution
Lane 1 : FBXO31 (aa 1-367) transfected 293T cell lysate
Lane 2 : Non-transfected 293T cell lysate
Lysates/proteins at 25 µg per lane.
Secondary
All lanes : Goat Anti-Mouse IgG (H&L)-HRP Conjugated at 1/2500 dilution
Predicted band size: 66 kDa
Observed band size: 40 kDa why is the actual band size different from the predicted?
データシートおよび資料
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Datasheet download
参考文献 (0)
ab68067 は論文での使用が確認できていません。
