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AB272898

Anti-FBXL16 抗体

Anti-FBXL16 antibody

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Rabbit Polyclonal FBXL16 antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human, Rat samples. Immunogen corresponding to Recombinant Fragment Protein within Human FBXL16.

別名を表示する

C16orf22, FBL16, FBXL16, F-box/LRR-repeat protein 16, F-box and leucine-rich repeat protein 16

4 Images
Immunocytochemistry/ Immunofluorescence - Anti-FBXL16 antibody (AB272898)
  • ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-FBXL16 antibody (AB272898)

Paraformaldehyde-fixed MCF7 cells stained for FBXL16 (green) using ab272898 at 1/500 dilution in ICC/IF analysis.

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FBXL16 antibody (AB272898)
  • IHC-P

Unknown

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FBXL16 antibody (AB272898)

Paraffin embedded rat brain tissue stained for FBXL16 using ab272898 at 1/500 dilution in immunohistochemical analysis. Antigen retrieval using EDTA based, pH 8.0 buffer, 15 minutes.

Western blot - Anti-FBXL16 antibody (AB272898)
  • WB

Unknown

Western blot - Anti-FBXL16 antibody (AB272898)

All lanes:

Western blot - Anti-FBXL16 antibody (ab272898) at 1/1000 dilution

Lane 1:

U-87 MG cell lysate at 30 µg

Lane 2:

SK-N-SH cell lysate at 30 µg

Lane 3:

IMR32 cell lysate at 30 µg

Lane 4:

SK-N-AS cell lysate at 30 µg

Secondary

All lanes:

HRP-conjugated anti-rabbit IgG antibody

Predicted band size: 51 kDa

false

Western blot - Anti-FBXL16 antibody (AB272898)
  • WB

Unknown

Western blot - Anti-FBXL16 antibody (AB272898)

All lanes:

Western blot - Anti-FBXL16 antibody (ab272898) at 1/1000 dilution

All lanes:

U-87 MG cell lysate at 30 µg

Predicted band size: 51 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Rat, Human

アプリケーション

ICC/IF, WB, IHC-P

applications

免疫原

Recombinant Fragment Protein within Human FBXL16. The exact immunogen used to generate this antibody is proprietary information.

Q8N461

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Reactivity data

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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: PBS, 20% Glycerol (glycerin, glycerine), 1% BSA
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

FBXL16 also known as F-box and leucine-rich repeat protein 16 is a member of the F-box protein family which contains an F-box motif responsible for protein-protein interactions. This protein weighs approximately 46 kDa and plays an important role in tagging proteins for ubiquitin-dependent proteolysis. Scientists find FBXL16 ubiquitously expressed with significant presence in tissues such as the brain heart and testis suggesting its versatile functional significance across different organ systems.
Biological function summary

FBXL16 serves within the cellular context by acting as a component of the Skp1-Cul1-F-box protein (SCF) E3 ubiquitin ligase complex directing specific substrate proteins for ubiquitination. By tagging these substrates FBXL16 contributes to regulated protein turnover modulating pathways necessary for various cellular activities such as cell cycle control and signaling. The efficiency of these cellular processes heavily depends on FBXL16's proper functioning within this complex.

Pathways

FBXL16 interacts with signaling cascades such as the cell cycle regulation pathway and the ubiquitin-proteasome system. These pathways ensure precise control of cell division and protein turnover. Within these pathways FBXL16 works alongside proteins like Skp2 and Cullin1 that form part of the SCF complexes ensuring selective and appropriate degradation of various cellular proteins.

FBXL16 shows links to cancer and neurodegenerative diseases. Its role in regulating cell cycle and protein degradation implicates FBXL16 in tumor progression when dysregulated. Further in neurodegenerative disorders FBXL16 might interact with proteins such as Parkin involved in ubiquitination suggesting its influence on neuronal health. Understanding FBXL16's role in these contexts can offer insights into potential therapeutic strategies targeting its pathway interactions.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex.
See full target information FBXL16
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Abcam product promise

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