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Anti-FBP17 抗体 (ab113961)

Submit a review Q&A (2)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FBP17 antibody (ab113961)
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FBP17 antibody (ab113961)
  • Western blot - Anti-FBP17 antibody (ab113961)

Key features and details

  • Goat polyclonal to FBP17
  • Suitable for: WB, IHC-P
  • Reacts with: Human
  • Isotype: IgG

製品の概要

  • 製品名

    Anti-FBP17 antibody
    FBP17 一次抗体 製品一覧

  • 製品の詳細

    Goat polyclonal to FBP17

  • 由来種

    Goat

  • アプリケーション

    適用あり: WB, IHC-Pmore details

  • 種交差性

    交差種: Human
    交差が予測される動物種: Mouse, Rat, Rabbit, Horse, Chicken, Dog, Pig, Zebrafish

  • 免疫原

    Synthetic peptide,

    KQLESSKRRFERDC

    , corresponding to internal sequence amino acids 132-145 of Human FBP17
    Run BLAST with BLAST the sequence with ExPASy Run BLAST with BLAST the sequence with NCBI

  • ポジティブ･コントロール

    • Human Small Intestine and Human Tonsil tissue Human testis lysate

  • 特記事項

    The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.

    If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As

製品の特性

  • 製品の状態

    Liquid

  • 保存方法

    Shipped at 4°C. Store at -20°C.

  • バッファー

    pH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 99% Tris buffered saline, 0.5% BSA
  • Concentration information loading...

  • 精製度

    Immunogen affinity purified

  • ポリ/モノ

    ポリクローナル

  • アイソタイプ

    IgG

  • 研究分野

アプリケーション

The Abpromise guarantee

Abpromise保証は、 次のテスト済みアプリケーションにおけるab113961の使用に適用されます

アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。

アプリケーション Abreviews 特記事項
WB
Use a concentration of 0.25 - 2 µg/ml. Predicted molecular weight: 71 kDa.
IHC-P
Use a concentration of 3.75 µg/ml.
特記事項
WB
Use a concentration of 0.25 - 2 µg/ml. Predicted molecular weight: 71 kDa.
IHC-P
Use a concentration of 3.75 µg/ml.

ターゲット情報

  • 機能

    May act as a link between RND2 signaling and regulation of the actin cytoskeleton (By similarity). Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. Binds to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promotes membrane invagination and the formation of tubules. Also enhances actin polymerization via the recruitment of WASL/N-WASP, which in turn activates the Arp2/3 complex. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. May be required for the lysosomal retention of FASLG/FASL.

  • 組織特異性

    Very highly expressed in the epithelial cells of the gastrointestinal tract, respiratory, reproductive and urinary systems. Also highly expressed in brown adipose tissue, cardiomyocytes, enteric ganglia and glucagon producing cells of the pancreas. Expressed in germ cells of the testis and all regions of the brain.

  • 関連疾患

    Note=A chromosomal aberration involving FNBP1 is found in acute leukemias. Translocation t(9;11)(q34;q23) with MLL. The relatively low incidence of the MLL-FNBP1 fusion protein in acute leukemia may reflect the marginal capacity of this fusion protein to induce cellular transformation.

  • 配列類似性

    Belongs to the FNBP1 family.
    Contains 1 FCH domain.
    Contains 1 REM (Hr1) repeat.
    Contains 1 SH3 domain.

  • 細胞内局在

    Cytoplasm. Cytoplasm > cytoskeleton. Cytoplasm > cell cortex. Lysosome. Cytoplasmic vesicle. Cell membrane. Enriched in cortical regions coincident with F-actin. Also localizes to endocytic vesicles and lysosomes.
  • Information by UniProt

  • 参照データベース

    see all

  • 別名

    • FBP1 antibody
    • FBP17 antibody
    • Fnbp1 antibody
    • FNBP1_HUMAN antibody
    • Formin binding protein 1 antibody
    • Formin binding protein 17 antibody
    • Formin-binding protein 1 antibody
    • Formin-binding protein 17 antibody
    • hFBP17 antibody
    • KIAA0554 antibody
    • MGC126804 antibody
    see all

画像

  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FBP17 antibody (ab113961)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FBP17 antibody (ab113961)
    Immunohistochemical staining of Human Small Intestine using ab113961 at 3.75µg/ml
  • Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FBP17 antibody (ab113961)
    Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FBP17 antibody (ab113961)
    Immunohistochemical staining of Human Tonsil using ab113961 at 3.75µg/ml
  • Western blot - Anti-FBP17 antibody (ab113961)
    Western blot - Anti-FBP17 antibody (ab113961)
    Anti-FBP17 antibody (ab113961) at 0.25 µg/ml + Human testis lysate at 35 µg

    Developed using the ECL technique.

    Predicted band size: 71 kDa



    Primary incubated for 1 hour.

参考文献 (0)

ab113961 を使用した論文を発表された方は、こちらまでお知らせください。データシートに掲載させていただきます。

ab113961 は論文での使用が確認できていません。

レビューと Q&A

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レビューを送る 質問を送る

1-2 of 2 Abreviews or Q&A

Question


Suite à notre conversation, je me suis rendue compte qu'une erreur s'était produite. Votre produit nous a donné pleinement satisfaction.
Je vous prie de m'excuser pour cette erreur.

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Answer

Merci beaucoup pour votre message et pour cette information.

J'ai mis à jour le système afin que l'anti-FBP17 ab113961 ne soit plus marqué comme étant problématique.

Bonne continuation dans vos travaux de recherche, n'hésitez pas à nous contacter de nouveau si nécessaire.

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Question

ab113961 reçu en remplacement du ab100918 ne fonctionne pas non plus.
Avoir ou remplacement par un anti-tubuline.

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Answer

Comme convenu par téléphone je serai ravi de demander au service financier d'Abcam d'éditer un avoir ou de procéder à un échange avec une unité d'anti-tubuline.

En échange, nous serions ravis si vous pouviez nous communiquer quelques détails concernant votre protocole en remplissant le questionnaire ci-joint. Ces informations sont très importantes pour nous car elles nous permettent d'investiguer la source du problème rencontré avec l'anticorps ab113961 et de prendre les dispositions nécessaires pour assurer une bonne qualité de nos produits.

Je vous remercie par avance de nous envoyer votre protocole.

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