AB121364

Anti-FAM172A 抗体

Name: Anti-FAM172A 抗体 (ab121364) | Abcam
Brand: Abcam Limited
SKU: AB121364
Price: 78000 JPY
Availability: InStock

Anti-FAM172A antibody

Be the first to review this product! Submit a review

(11 Publications)

Rabbit Polyclonal FAM172A antibody. Suitable for ICC/IF and reacts with Human samples. Cited in 11 publications. Immunogen corresponding to Recombinant Fragment Protein within Human ARB2A aa 1-150.

別名を表示する

C5orf21, FAM172A, ARB2A, Cotranscriptional regulator ARB2A, ARB2 cotranscriptional regulator A, Cotranscriptional regulator FAM172A, Protein FAM172A

1 Images

Immunocytochemistry/ Immunofluorescence - Anti-FAM172A antibody (AB121364)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-FAM172A antibody (AB121364)

Immunocytochemistry analysis of U-251 MG (human brain glioma cell line) cells labelling FAM172A with ab121364 at 2 μg/mL.

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

ICC/IF

applications

免疫原

Recombinant Fragment Protein within Human ARB2A aa 1-150. The exact immunogen used to generate this antibody is proprietary information.

Q8WUF8

style

left-column

Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "0.25-2 µg/mL", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

style

left-column

style

left-column

出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

pH: 7.2 Preservative: 0.02% Sodium azide Constituents: PBS, 40% Glycerol (glycerin, glycerine)

出荷温度

Blue Ice

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

style

left-column

補足情報

This supplementary information is collated from multiple sources and compiled automatically.

FAM172A also known as KIAA1690 is a protein that plays a significant role in the human body. It has an approximate molecular mass of 72 kDa. Researchers find FAM172A expression in various tissues indicating active participation in multiple cellular processes. Due to its widespread presence it attracts much interest in functional studies although specific details about its biochemical activity remain under investigation.

Biological function summary

The protein encoded by FAM172A participates in the cellular maintenance processes. While not conclusively part of any known complex its interactions suggest a regulatory role potentially in nucleic acid binding or cellular signaling processes. Studies also show its presence at the transcriptional level in cells indicating an influence on gene expression.

Pathways

FAM172A potentially connects to important cellular signaling pathways including the PI3K-Akt pathway. This pathway is important for cell survival and proliferation. Additionally FAM172A shows interaction tendencies with proteins like Akt1 reinforcing its participation in signaling networks that maintain cellular health and function.

FAM172A has associations with conditions like cancer. Its role in cellular growth pathways suggests that mutations or dysregulation of FAM172A might contribute to oncogenesis. Connections to proteins involved in cancer-related pathways including mTOR indicate potential targets for therapeutic intervention. Researchers continue to investigate how alterations in FAM172A expression or function contribute to disease states aiming for new treatment strategies.

style

left-column

style

left-column

製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

style

left-column

ターゲットの情報

Plays a role in the regulation of alternative splicing, by interacting with AGO2 and CHD7. Seems to be required for stabilizing protein-protein interactions at the chromatin-spliceosome interface. May have hydrolase activity.

See full target information ARB2A

style

left-column

文献 (11)

Recent publications for all applications. Explore the full list and refine your search

Advanced science (Weinheim, Baden-Wurttemberg, Germany) 12:e2414723 PubMed39960327

2025

Fam172a Mediates the Stimulation of Hypothalamic Oxytocin Neurons to Suppress Obesity-Induced Anxiety.

Applications

Unspecified application

Species

Unspecified reactive species

Baocheng Wan,Lina Zhang,Xinyu Wang,Rong Zhang,Lianxi Li,Yi Zhang,Zhuo Chen,Cheng Hu

Nature communications 15:10111 PubMed39578459

2024

Histone lactylation mediated by Fam172a in POMC neurons regulates energy balance.

Applications

Unspecified application

Species

Unspecified reactive species

Zhuo Chen,Baocheng Wan,Hong Zhang,Lina Zhang,Rong Zhang,Lianxi Li,Yi Zhang,Cheng Hu

International journal of oncology 63: PubMed37264959

2023

mA‑mediated LINC02038 inhibits colorectal cancer progression via regulation of the FAM172A/PI3K/AKT pathway via competitive binding with miR‑552‑5p.

Applications

Unspecified application

Species

Unspecified reactive species

Wenjun Liu,Zilang Zhang,Xitu Luo,Kai Qian,Baojun Huang,Jianmin Liang,Zhihao Ma,Jianzhong Deng,Chengyu Yang

Life science alliance 6: PubMed37221016

2023

The CHARGE syndrome-associated protein FAM172A controls AGO2 nuclear import.

Applications

Unspecified application

Species

Unspecified reactive species

Sephora Sallis,Félix-Antoine Bérubé-Simard,Benoit Grondin,Elizabeth Leduc,Fatiha Azouz,Catherine Bélanger,Nicolas Pilon

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 36:e22176 PubMed35129866

2022

CHARGE syndrome-associated proteins FAM172A and CHD7 influence male sex determination and differentiation through transcriptional and alternative splicing mechanisms.

Applications

Unspecified application

Species

Unspecified reactive species

Catherine Bélanger,Tatiana Cardinal,Elizabeth Leduc,Robert S Viger,Nicolas Pilon

Digestive diseases and sciences : PubMed32945983

2020

FAM172A Deletion May Enhance Hepatic Steatosis by Promoting ER Stress.

Applications

Unspecified application

Species

Unspecified reactive species

Fan Xiao,Meixin Gao,Junru Yang,Lingling He,Hongshan Wei

Translational cancer research 9:5637-5644 PubMed35117927

2020

FAM172A affects cell proliferation and apoptosis not by targeting β-tubulin in HepG2 cells.

Applications

Unspecified application

Species

Unspecified reactive species

Ai-Min Xu,Chuan-Jiang He,Zureguli Tuerxun,Abuduaini Anikezi

Biology open 9: PubMed31988090

2020

FAM172A inhibits EMT in pancreatic cancer via ERK-MAPK signaling.

Applications

Unspecified application

Species

Unspecified reactive species

Ying Chen,Peihui Liu,Di Shen,Han Liu,Lepeng Xu,Jian Wang,Daguang Shen,He Sun,Hongkui Wu

Oncology letters 14:3587-3593 PubMed28927116

2017

Expression of family with sequence similarity 172 member A and nucleotide-binding protein 1 is associated with the poor prognosis of colorectal carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Wenjun Liu,Shuang Wang,Kai Qian,Jinqian Zhang,Zhi Zhang,Hao Liu

Oncology reports 37:3554-3564 PubMed28440497

2017

miR‑27a promotes proliferation, migration, and invasion of colorectal cancer by targeting FAM172A and acts as a diagnostic and prognostic biomarker.

Applications

Unspecified application

Species

Unspecified reactive species

Wenjun Liu,Kai Qian,Xing Wei,Haijun Deng,Bei Zhao,Qing Chen,Jinqian Zhang,Hao Liu

View all publications

style

left-column

style

left-column

style

right-column

Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-FAM172A 抗体

Anti-FAM172A antibody

Immunocytochemistry/ Immunofluorescence - Anti-FAM172A antibody (AB121364)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (11)

組合せ製品

Secondary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Abcam product promise