AB229254

Anti-FAM120A/OSSA 抗体

Name: Anti-FAM120A/OSSA 抗体 (ab229254) | Abcam
Brand: Abcam Limited
SKU: AB229254
Price: 74000 JPY
Availability: InStock

Anti-FAM120A/OSSA antibody

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(3 Publications)

Rabbit Polyclonal FAM120A/OSSA antibody. Suitable for WB, IHC-P, ICC/IF and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Fragment Protein within Human FAM120A.

別名を表示する

C9orf10, KIAA0183, OSSA, FAM120A, Constitutive coactivator of PPAR-gamma-like protein 1, Oxidative stress-associated SRC activator, Protein FAM120A

3 Images

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAM120A/OSSA antibody (AB229254)

IHC-P

Supplier Data

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAM120A/OSSA antibody (AB229254)

Paraffin-embedded human breast cancer tissue stained for FAM120A/OSSA with ab229254 at 1/250 dilution in immunohistochemical analysis.

Immunocytochemistry/ Immunofluorescence - Anti-FAM120A/OSSA antibody (AB229254)

ICC/IF

Supplier Data

Immunocytochemistry/ Immunofluorescence - Anti-FAM120A/OSSA antibody (AB229254)

A431 (human epidermoid carcinoma cell line) cells stained for FAM120A/OSSA (green) using ab229254 (1/500 dilution) in ICC/IF. Cells were fixed in 4% paraformaldehyde at RT for 15 minutes.

Nuclear counterstain : Hoechst 33342 (blue).

Supplier Data

Western blot - Anti-FAM120A/OSSA antibody (AB229254)

7.5% SDS-PAGE

All lanes:

Western blot - Anti-FAM120A/OSSA antibody (ab229254) at 1/1000 dilution

All lanes:

MCF7 (human breast adenocarcinoma cell line) whole cell lysate at 30 µg

Predicted band size: 121 kDa

true

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

交差種

Human

アプリケーション

WB, IHC-P, ICC/IF

applications

免疫原

Recombinant Fragment Protein within Human FAM120A. The exact immunogen used to generate this antibody is proprietary information.

Q9NZB2

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "IHCP" : {"fullname" : "Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)", "shortname":"IHC-P"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/3000", "WB-species-notes": "", "IHCP-species-checked": "testedAndGuaranteed", "IHCP-species-dilution-info": "1/100 - 1/1000", "IHCP-species-notes": "", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/100 - 1/1000", "ICCIF-species-notes": "" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Cow": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "IHCP-species-checked": "predicted", "IHCP-species-dilution-info": "", "IHCP-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }

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出荷温度及び保存条件

製品の状態

Liquid

精製方法

Affinity purification Immunogen

バッファー組成

pH: 7 Preservative: 0.01% Thimerosal (merthiolate) Constituents: 20% Glycerol (glycerin, glycerine), 1.21% Tris, 0.75% Glycine

出荷温度

Blue Ice

短期保存期間

1-2 weeks

短期保存温度

+4°C

長期保存温度

-20°C

分注に関する情報

Upon delivery aliquot

保管に関する情報

Avoid freeze / thaw cycle

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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

FAM120A also known as OSSA is a protein that plays a role in cellular signaling. It has a mass of approximately 120 kDa. Researchers observe the expression of this protein in various tissues including testis ovary and brain. FAM120A functions as a scaffolding protein which means it helps organize other proteins at specific locations within cells to facilitate interactions and signaling pathways.

Biological function summary

FAM120A interacts with numerous cellular components and exhibits roles in regulating stress response. It integrates into the RNA granule complex allowing it to influence RNA stability and translation. Through its interaction with the cytoplasmic polyadenylation element-binding proteins it modulates mRNA processing offering insight into how cells manage protein production in response to environmental changes.

Pathways

FAM120A becomes integrated into signaling cascades like the PI3K/Akt pathway. It influences cell survival and growth by modulating interactions with proteins such as Src and Grb2. These interactions contribute to the regulation of key signaling activities that impact various cell functions including proliferation and apoptosis.

FAM120A has connections to cancer and cardiomyopathies. Alterations in its expression or function may affect disease pathogenesis. For instance its relationship with Src contributes to oncogenic signaling pathways influencing cancer progression. In cardiac diseases this protein interacts with pathways that involve binding partners like PI3K where its dysregulation can lead to aberrant heart function or pathology.

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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:

Visit the General protocols
Visit the Troubleshooting

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ターゲットの情報

Component of the oxidative stress-induced survival signaling. May regulate the activation of SRC family protein kinases (PubMed : 19015244). May act as a scaffolding protein enabling SRC family protein kinases to phosphorylate and activate PI3-kinase (PubMed : 19015244). Binds IGF2 RNA and promotes the production of IGF2 protein (PubMed : 19015244).

See full target information FAM120A

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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Bioactive materials 53:737-753 PubMed40801020

2025

Inhibition of ARH2 by pH/ROS-responsive nanosystem for improved lung adenocarcinoma immunochemotherapy.

Applications

Unspecified application

Species

Unspecified reactive species

Rui Cai,Meng Wang,Mengting Pan,Zhiwu Zhang,Qiang Jia,Longbao Feng,Zhongjian Yu,Lu Liu,Tongyu Zhu,Silin Cai,Han Tian,Jiangyu Zhang,Rui Guo,Yanfang Zheng

Communications biology 7:399 PubMed38565940

2024

FAM120A deficiency improves resistance to cisplatin in gastric cancer by promoting ferroptosis.

Applications

Unspecified application

Species

Unspecified reactive species

Liangbo Niu,Yi Li,Guixiang Huang,Wei Huang,Jing Fu,Lu Feng

Journal of translational medicine 19:492 PubMed34861864

2021

CircSERPINA3 regulates SERPINA3-mediated apoptosis, autophagy and aerobic glycolysis of prostate cancer cells by competitively binding to MiR-653-5p and recruiting BUD13.

Applications

Unspecified application

Species

Unspecified reactive species

Zengshu Xing,Sailian Li,Zhenxiang Liu,Chong Zhang,Zhiming Bai

View all publications

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Abcam product promise

当社は、高品質な試薬を通じてお客様の研究を力強くサポートすることをお約束いたします。ご使用いただく各段階で、常にお客様をサポートできる体制を整えております。万が一、製品が期待通りに機能しない場合は、「Abcam Product Promise」による当社保証制度に基づき、安心してご利用いただけます。

保証に関する詳細については利用規約をご確認ください。

Please note: All products are 'FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES'.

For licensing inquiries, please contact partnerships@abcam.com

Anti-FAM120A/OSSA 抗体

Anti-FAM120A/OSSA antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-FAM120A/OSSA antibody (AB229254)

Immunocytochemistry/ Immunofluorescence - Anti-FAM120A/OSSA antibody (AB229254)

Western blot - Anti-FAM120A/OSSA antibody (AB229254)

Key facts

宿主種

クローン性

アイソタイプ

キャリアフリー

交差種

アプリケーション

免疫原

代替製品

Primary Antibodies

Primary Antibodies

組合せ製品

Primary Antibodies

Primary Antibodies

Primary Antibodies

Primary Antibodies

Reactivity data

出荷温度及び保存条件

製品の状態

精製方法

バッファー組成

出荷温度

短期保存期間

短期保存温度

長期保存温度

分注に関する情報

保管に関する情報

補足情報

Biological function summary

Pathways

製品プロトコール

ターゲットの情報

文献 (3)

Abcam product promise