Anti-Factor Xa Heavy Chain 抗体 (ab180701)
Key features and details
- Rabbit polyclonal to Factor Xa Heavy Chain
- Suitable for: WB
- Reacts with: Human
- Isotype: IgG
製品の概要
-
製品名
Anti-Factor Xa Heavy Chain antibody
Factor Xa Heavy Chain 一次抗体 製品一覧 -
製品の詳細
Rabbit polyclonal to Factor Xa Heavy Chain -
由来種
Rabbit -
アプリケーション
適用あり: WBmore details -
種交差性
交差種: Human
交差が予測される動物種: Rat
-
免疫原
Recombinant fragment corresponding to Human Factor Xa Heavy Chain aa 235-488.
Sequence:IVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRF KVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITF RMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPY VDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVT GIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITS SPLK
Database link: P00742 -
ポジティブ･コントロール
- HepG2 cell extract.
-
特記事項
The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
-
製品の状態
Liquid -
保存方法
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle. -
バッファー
pH: 7.30
Preservative: 0.02% Sodium azide
Constituents: 49% PBS, 50% Glycerol -
Concentration information loading... -
精製度
Immunogen affinity purified -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
-
Compatible Secondaries
-
Isotype control
-
Positive Controls
-
Related Products
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab180701の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| WB |
1/500 - 1/2000. Predicted molecular weight: 55 kDa.
|
| 特記事項 |
|---|
|
WB
1/500 - 1/2000. Predicted molecular weight: 55 kDa. |
ターゲット情報
-
機能
Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. -
組織特異性
Plasma; synthesized in the liver. -
関連疾患
Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis. -
配列類似性
Belongs to the peptidase S1 family.
Contains 2 EGF-like domains.
Contains 1 Gla (gamma-carboxy-glutamate) domain.
Contains 1 peptidase S1 domain. -
翻訳後修飾
The vitamin K-dependent, enzymatic carboxylation of some glutamate residues allows the modified protein to bind calcium.
N- and O-glycosylated.
The activation peptide is cleaved by factor IXa (in the intrinsic pathway), or by factor VIIa (in the extrinsic pathway).
The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains. -
細胞内局在
Secreted. - Information by UniProt
-
参照データベース
- Entrez Gene: 2159 Human
- Entrez Gene: 29243 Rat
- Omim: 613872 Human
- SwissProt: P00742 Human
- SwissProt: Q63207 Rat
- Unigene: 361463 Human
- Unigene: 21393 Rat
-
別名
- Activated factor Xa heavy chain antibody
- Coagulation factor X antibody
- F10 antibody
see all
画像
-
Western blot - Anti-Factor Xa Heavy Chain antibody (ab180701)Anti-Factor Xa Heavy Chain antibody (ab180701) at 1/500 dilution + HepG2 cell extract
Predicted band size: 55 kDa
プロトコール
データシートおよび資料
-
SDS download
-
Datasheet download
参考文献 (1)
ab180701 は 1 報の論文で使用されています。
- Schuliga M et al. Annexin A2 contributes to lung injury and fibrosis by augmenting factor Xa fibrogenic activity. Am J Physiol Lung Cell Mol Physiol 312:L772-L782 (2017). PubMed: 28283478