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AB61370

Anti-Factor VIII 抗体

Anti-Factor VIII antibody

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(3 Publications)

Sheep Polyclonal Factor VIII antibody. Suitable for ELISA, FuncS (Neut/Block) and reacts with Human samples. Cited in 3 publications. Immunogen corresponding to Recombinant Full Length Protein corresponding to Human F8.

別名を表示する

F8C, F8, Coagulation factor VIII, Antihemophilic factor, Procoagulant component, AHF

Key facts

宿主種

Sheep

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

ELISA, FuncS (Neut/Block)

applications

免疫原

Recombinant Full Length Protein corresponding to Human F8.

P00451

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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "ELISA" : {"fullname" : "ELISA", "shortname":"ELISA"}, "FuncSNeutBlock" : {"fullname" : "Functional Studies (Neut/Block)", "shortname":"FuncS (Neut/Block)"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "ELISA-species-checked": "guaranteed", "ELISA-species-dilution-info": "", "ELISA-species-notes": "<p></p>", "FuncSNeutBlock-species-checked": "guaranteed", "FuncSNeutBlock-species-dilution-info": "", "FuncSNeutBlock-species-notes": "<p>Binds FVIII/vWF complex in plasma.</p>" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Ion exchange chromatography
精製に関する特記事項
Salt fractionation followed by ion exchange chromatography.
バッファー組成
Constituents: 50% Glycerol (glycerin, glycerine), 50% Water
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
分注に関する情報
Upon delivery aliquot
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Factor VIII also known as anti-hemophilic factor is a glycoprotein with a molecular mass of approximately 250 kDa. This protein circulates in the plasma mainly in the liver where hepatocytes produce it. Factor VIII remains inactive while circulating in the blood and exists within the factor VIII/von Willebrand factor complex. Upon activation it plays a significant role in the blood coagulation process.
Biological function summary

Factor VIII greatly contributes to hemostasis by serving as a cofactor for factor IXa forming the intrinsic tenase complex. This activation results in the conversion of factor X to factor Xa which is important for the common pathway of the coagulation cascade. By participating in the clotting process factor VIII ensures proper wound healing and prevention of blood loss.

Pathways

Factor VIII activity is pivotal within the coagulation cascade particularly the intrinsic and common pathways. Activation of the intrinsic pathway begins through interactions with factor IXa leading to efficient activation of factor X. This process closely relates factor VIII to proteins like factor IX and factor X ensuring proper clot formation and stabilization. Factor VIII products and assays are available to study and characterize its critical role in these pathways.

Factor VIII is closely associated with hemophilia A a genetic bleeding disorder resulting from deficiency or dysfunction of this protein. Patients with hemophilia A exhibit prolonged bleeding times due to impaired coagulation. The disorder links directly to von Willebrand factor as it protects factor VIII from degradation in circulation stabilizing its presence in the blood. Anti-factor VIII antibodies are important tools for diagnosing and studying factor VIII-related disorders.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Factor VIII, along with calcium and phospholipid, acts as a cofactor for F9/factor IXa when it converts F10/factor X to the activated form, factor Xa.
See full target information F8
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文献 (3)

Recent publications for all applications. Explore the full list and refine your search

Drug delivery 32:2449376 PubMed39789884

2025

In vivo antitumor activity of PHT-427 inhibitor-loaded polymeric nanoparticles in head and neck squamous cell carcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Joaquín Yanes-Díaz,Raquel Palao-Suay,Francisca Inmaculada Camacho-Castañeda,Juan Riestra-Ayora,María Rosa Aguilar,Ricardo Sanz-Fernández,Carolina Sánchez-Rodríguez

Journal of thrombosis and haemostasis : JTH 18:306-317 PubMed31562694

2019

A mathematical model of coagulation under flow identifies factor V as a modifier of thrombin generation in hemophilia A.

Applications

Unspecified application

Species

Unspecified reactive species

Kathryn G Link,Michael T Stobb,Matthew G Sorrells,Maria Bortot,Katherine Ruegg,Marilyn J Manco-Johnson,Jorge A Di Paola,Suzanne S Sindi,Aaron L Fogelson,Karin Leiderman,Keith B Neeves

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 26:755-61 PubMed26192111

2015

Comparison of human coagulation factor VIII expression directed by cytomegalovirus and mammary gland-specific promoters in HC11 cells and transgenic mice.

Applications

ELISA

Species

Unspecified reactive species

Qing Wang,Siguo Hao,Liyuan Ma,Wenhao Zhang,Jiangbo Wan,Xiaohui Deng
View all publications
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代替製品

Primary Antibodies

AB78852

Anti-Factor VIII antibody [GMA-012]

BOND RX™ Validated

Western blot - Anti-Factor VIII antibody [GMA-012] (AB78852)

  • 0
  • 0
Primary Antibodies

AB171825

Anti-Factor VIII antibody

Western blot - Anti-Factor VIII antibody (AB171825)

  • 0
  • 0
Primary Antibodies

AB203590

Anti-Factor VIII antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-Factor VIII antibody (AB203590)

  • 0
  • 0
Primary Antibodies

AB236284

Anti-Factor VIII antibody

Immunocytochemistry/ Immunofluorescence - Anti-Factor VIII antibody (AB236284)

  • 0
  • 0

組合せ製品

Assay Kits

AB108830

Factor VII Activity Assay Kit (Human, Colorimetric)

Functional Studies - Factor VII Activity Assay Kit (Human, Colorimetric) (AB108830)

  • 0
  • 0
Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB154193

Anti-Von Willebrand Factor antibody [EPSISR15]

RabMAb|Recombinant

Immunocytochemistry/ Immunofluorescence - Anti-Von Willebrand Factor antibody [EPSISR15] (AB154193)

  • 0
  • 0
Primary Antibodies

AB255824

Anti-Factor IX/PTC antibody [EPR22846-238]

RabMAb|Recombinant

Immunoprecipitation - Anti-Factor IX/PTC antibody [EPR22846-238] (AB255824)

  • 0
  • 0
Primary Antibodies

AB28364

Anti-CD31 antibody

BOND RX™ Validated|Lab Essentials

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-CD31 antibody (AB28364)

  • 4
  • 160

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