Anti-Factor Va 抗体 (ab81460)
Key features and details
- Sheep polyclonal to Factor Va
- Suitable for: ELISA, WB
- Reacts with: Human
- Isotype: IgG
リコンビナント抗体で、ロット間での高い再現性を実現
- 異なるロット間での安定した再現性
- 容易なスケールアップ
- 評価試験による特異性の確認済み
- 倫理基準に準拠 - アニマル・フリーの生産
製品の概要
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製品名
Anti-Factor Va antibody -
製品の詳細
Sheep polyclonal to Factor Va -
由来種
Sheep -
アプリケーション
適用あり: ELISA, WBmore details -
種交差性
交差種: Human -
免疫原
Native, purified human Factor Va
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特記事項
Concentration 5-10mg/ml (lot specific).The Life Science industry has been in the grips of a reproducibility crisis for a number of years. Abcam is leading the way in addressing this with our range of recombinant monoclonal antibodies and knockout edited cell lines for gold-standard validation. Please check that this product meets your needs before purchasing.
If you have any questions, special requirements or concerns, please send us an inquiry and/or contact our Support team ahead of purchase. Recommended alternatives for this product can be found below, along with publications, customer reviews and Q&As
製品の特性
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製品の状態
Liquid -
保存方法
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles. -
バッファー
Constituent: 50% Glycerol -
Concentration information loading... -
精製度
Ion Exchange Chromatography -
特記事項（精製）
Salt fractionation followed by ion exchange chromatography on DEAE sepharose. -
ポリ/モノ
ポリクローナル -
アイソタイプ
IgG -
研究分野
関連製品
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Isotype control
アプリケーション
The Abpromise guarantee
Abpromise保証は、 次のテスト済みアプリケーションにおけるab81460の使用に適用されます
アプリケーションノートには、推奨の開始希釈率がありますが、適切な希釈率につきましてはご検討ください。
| アプリケーション | Abreviews | 特記事項 |
|---|---|---|
| ELISA |
Use at an assay dependent concentration.
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| WB |
Use at an assay dependent concentration.
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| 特記事項 |
|---|
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ELISA
Use at an assay dependent concentration. |
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WB
Use at an assay dependent concentration. |
ターゲット情報
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関連性
Factor Va is a cofactor for the serine protease factor Xa, and in the presence of calcium ions they collectively assemble on a phospholipid surface to form the prothrombinase complex. The prothrombinase complex is responsible for the rapid conversion of prothrombin to thrombin. Factor Va is derived from the pro-cofactor, factor V, upon limited proteolysis by alpha-thrombin. The thrombin cleavage of factor V liberates two heavily glycosylated activation peptides from the central portion of the molecule which have no cofactor function. Factor Va is comprised of an NH2-terminal derived heavy chain (MW 94kDa) and a COOH-terminal derived light chain (MW 74kDa) which remain associated in the presence of calcium ions. The cofactor binds to phospholipid (cell membrane) surfaces and effectively serves as a receptor for membrane bound factor Xa. Complete assembly of the prothrombinase complex (factor Xa, factor Va, phospholipid, and calcium) results in a 300,000-fold increase in the rate of prothrombin conversion relative to the rate observed with factor Xa alone. The interaction between factor Va and factor Xa is mediated by both the heavy and light chain of factor Va, while the binding of prothrombin to factor Va is mediated solely by the heavy chain. -
細胞内局在
Cell Membrane and Plasma membrane -
参照データベース
- Entrez Gene: 2153 Human
- Omim: 612309 Human
- SwissProt: P12259 Human
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別名
- Activated protein c cofactor antibody
- Coagulation factor V (proaccelerin, labile factor) antibody
- Coagulation factor V antibody
see all
データシートおよび資料
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SDS download
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Datasheet download
参考文献 (0)
ab81460 は論文での使用が確認できていません。