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AB17932

Anti-Factor B 抗体 [9B8]

Anti-Factor B antibody [9B8]

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(2 Publications)

Anti-Factor B antibody [9B8] (ab17932) is a mouse monoclonal antibody detecting Factor B in Western Blot, ELISA. Suitable for Human.

- Trusted since 2005

別名を表示する

BF, BFD, CFB, Complement factor B, C3/C5 convertase, Glycine-rich beta glycoprotein, PBF2, Properdin factor B, GBG

Key facts

宿主種

Mouse

クローン性

Monoclonal

クローン番号

9B8

アイソタイプ

IgG1

軽鎖のタイプ

kappa

キャリアフリー

No

交差種

Human

アプリケーション

WB, ELISA

applications

免疫原

Native Full Length Protein corresponding to Human CFB.

P00751

特異性

ab17932 is specific for the Bb fragment of human factor B. In Western blotting, after SDS-PAGE, this antibody reacts with the Bb fragment of factor B in non-reduced form only. Antibody binding abolishes the formation of C3bBb complexes.

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Reactivity data

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製品の詳細

What is this antibody validated in?
Anti-Factor B antibody [9B8] (ab17932) is a mouse monoclonal antibody and is validated for use in Western Blot (WB), ELISA in Human samples.
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Protein G
バッファー組成
pH: 7.4 Preservative: 0.097% Sodium azide Constituents: PBS, 2.9% Sodium chloride
出荷温度
Blue Ice
短期保存期間
1-2 weeks
短期保存温度
+4°C
長期保存温度
-20°C
保管に関する情報
Avoid freeze / thaw cycle
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

Factor B also known as B-factor is a protein that plays an important role in the immune system specifically in the complement pathway. It is sometimes referred to as factor B complement and its gene identifier is often referenced as KY21 NNL or factor B 1001. Factor B has a molecular mass of approximately 93 kDa. It is mainly expressed in the liver but can also be found in blood plasma in its inactive form as part of the innate immune response.
Biological function summary

Factor B is involved in the alternative complement pathway which serves as a part of the body's defense mechanism. It participates in the formation of the C3 convertase together with factor D and properdin initiating a cascade that can lead to the opsonization and elimination of pathogens. Factor B undergoes cleavage by factor D which generates the Ba and Bb fragments with Bb functioning as a serine protease within the C3 convertase complex.

Pathways

Factor B contributes to the complement system interacting notably in the alternative and lectin pathways. In these pathways Factor B associates with proteins like complement component C3. The alternative pathway is activated on microbial surfaces independent of antibodies. The involvement of Factor B in these pathways illustrates its role in pathogen recognition and further highlights its cooperation with complement proteins such as C3 and properdin.

Factor B has been associated with atypical hemolytic uremic syndrome (aHUS) a rare and serious disease affecting kidney function. Factor B involvement in aHUS links it to abnormal complement activation leading to a pathological condition. Additionally Factor B connects to age-related macular degeneration (AMD) a disorder where complement pathway genetic variations including those involving Factor B have shown associations. Understanding interactions with other complement components such as factor H helps to elucidate its role in these diseases.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments : Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.
See full target information CFB
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文献 (2)

Recent publications for all applications. Explore the full list and refine your search

Cancers 13: PubMed34201241

2021

Development of EndoScreen Chip, a Microfluidic Pre-Endoscopy Triage Test for Esophageal Adenocarcinoma.

Applications

Unspecified application

Species

Unspecified reactive species

Julie A Webster,Alain Wuethrich,Karthik B Shanmugasundaram,Renee S Richards,Wioleta M Zelek,Alok K Shah,Louisa G Gordon,Bradley J Kendall,Gunter Hartel,B Paul Morgan,Matt Trau,Michelle M Hill

Frontiers in oncology 11:639980 PubMed33898314

2021

LncRNA LIPE-AS1 Predicts Poor Survival of Cervical Cancer and Promotes Its Proliferation and Migration via Modulating miR-195-5p/MAPK Pathway.

Applications

Unspecified application

Species

Unspecified reactive species

Jie Zhang,Pinping Jiang,Shoyu Wang,Wenjun Cheng,Shilong Fu
View all publications
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代替製品

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組合せ製品

Assay Kits

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Primary Antibodies

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BOND RX™ Validated|RabMAb|Recombinant|KO Validated

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Primary Antibodies

AB87424

Anti-C4d antibody

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Secondary Antibodies

AB150077

Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488)

Immunocytochemistry/ Immunofluorescence - Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (AB150077)

  • 5
  • 20
Primary Antibodies

AB118820

Anti-Factor H antibody [OX-24]

Trial Size

ELISA - Anti-Factor H antibody [OX-24] (AB118820)

  • 0
  • 0

Abcam product promise

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