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AB64909

Anti-ETV6 / Tel 抗体

Anti-ETV6 / Tel antibody

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(1 Publication)

Rabbit Polyclonal ETV6 / Tel antibody. Suitable for WB, ICC/IF and reacts with Human samples. Cited in 1 publication. Immunogen corresponding to Synthetic Peptide within Human ETV6.

別名を表示する

TEL, TEL1, ETV6, Transcription factor ETV6, ETS translocation variant 6, ETS-related protein Tel1, Tel

2 Images
Immunocytochemistry/ Immunofluorescence - Anti-ETV6 / Tel antibody (AB64909)
  • ICC/IF

Unknown

Immunocytochemistry/ Immunofluorescence - Anti-ETV6 / Tel antibody (AB64909)

ab64909, at 1/500 dilution, staining HeLa cells by immunofluorescence in the absence (left) or presence (right) of immunsing peptide.

Western blot - Anti-ETV6 / Tel antibody (AB64909)
  • WB

Unknown

Western blot - Anti-ETV6 / Tel antibody (AB64909)

All lanes:

Western blot - Anti-ETV6 / Tel antibody (ab64909) at 1/500 dilution

Lane 1:

extracts from HeLa cells at 30 µg

Lane 2:

extracts from HepG2 cells at 30 µg

Lane 3:

extracts from Jurkat cells at 30 µg

Lane 4:

extracts from Jurkat cells at 30 µg with immunising peptide

Predicted band size: 53 kDa

Observed band size: 53 kDa

false

Key facts

宿主種

Rabbit

クローン性

Polyclonal

アイソタイプ

IgG

キャリアフリー

No

交差種

Human

アプリケーション

WB, ICC/IF

applications

免疫原

Synthetic Peptide within Human ETV6. The exact immunogen used to generate this antibody is proprietary information.

P41212

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代替製品

Primary Antibodies

AB185816

Anti-ETV6 / Tel antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETV6 / Tel antibody (AB185816)

  • 0
  • 0
Primary Antibodies

AB223705

Anti-ETV6 / Tel antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-ETV6 / Tel antibody (AB223705)

  • 0
  • 0

組合せ製品

Primary Antibodies

AB186831

Anti-DP1 antibody

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - Anti-DP1 antibody (AB186831)

  • 2
  • 3
Primary Antibodies

AB134175

Anti-Cyclin D1 antibody [EPR2241] - C-terminal

20ul selling size|BOND RX™ Validated|KO Validated|RabMAb|Recombinant|Lab Essentials

Western blot - Anti-Cyclin D1 antibody [EPR2241] - C-terminal (AB134175)

  • 5
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Primary Antibodies

AB4729

Anti-Histone H3 (acetyl K27) antibody - ChIP Grade

BOND RX™ Validated

ChIP - Anti-Histone H3 (acetyl K27) antibody - ChIP Grade (AB4729)

  • 5
  • 85
Primary Antibodies

AB8580

Anti-Histone H3 (tri methyl K4) antibody - ChIP Grade

BOND RX™ Validated

ChIP - Anti-Histone H3 (tri methyl K4) antibody - ChIP Grade (AB8580)

  • 5
  • 90
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Reactivity data

{ "title": "Reactivity Data", "filters": { "stats": ["", "Species", "Dilution Info", "Notes"], "tabs": { "all-applications": {"fullname" : "All Applications", "shortname": "All Applications"}, "WB" : {"fullname" : "Western blot", "shortname":"WB"}, "ICCIF" : {"fullname" : "Immunocytochemistry/ Immunofluorescence", "shortname":"ICC/IF"} }, "product-promise": { "all": "all", "testedAndGuaranteed": "tested", "guaranteed": "expected", "predicted": "predicted", "notRecommended": "not-recommended" } }, "values": { "Human": { "WB-species-checked": "testedAndGuaranteed", "WB-species-dilution-info": "1/500 - 1/1000", "WB-species-notes": "<p></p>", "ICCIF-species-checked": "testedAndGuaranteed", "ICCIF-species-dilution-info": "1/500 - 1/1000", "ICCIF-species-notes": "<p></p>" }, "Mouse": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" }, "Rat": { "WB-species-checked": "predicted", "WB-species-dilution-info": "", "WB-species-notes": "", "ICCIF-species-checked": "predicted", "ICCIF-species-dilution-info": "", "ICCIF-species-notes": "" } } }
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出荷温度及び保存条件

製品の状態
Liquid
精製方法
Affinity purification Immunogen
バッファー組成
pH: 7.4 Preservative: 0.02% Sodium azide Constituents: PBS, 50% Glycerol (glycerin, glycerine), 0.87% Sodium chloride
出荷温度
Blue Ice
短期保存温度
+4°C
長期保存温度
-20°C
保管に関する情報
Stable for 12 months at -20°C
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補足情報

This supplementary information is collated from multiple sources and compiled automatically.

ETV6 also known as Tel is a transcription factor encoded by the ETV6 gene. It weighs approximately 57 kDa. The protein is expressed in various tissues including hematopoietic cells which are cells that form blood cells. ETV6 contains a pointed (PNT) domain and an ETS DNA-binding domain which allow it to regulate gene expression by binding to specific DNA sequences. It functions in the nucleus where it influences cell cycle progression and differentiation.
Biological function summary

ETV6 impacts processes key to hematopoiesis and is often part of transcriptional regulatory complexes. It guides critical decisions in hematopoietic stem cells promoting lineage commitment and modulating cell cycle regulation. This protein acts as a repressor or activator depending on the context influencing target gene expression and sustaining the balance necessary for blood cell differentiation and maintenance. Its ability to interact with co-factors like HDACs (histone deacetylases) broadens its regulatory potential.

Pathways

ETV6 integrates into signaling pathways that manage cellular development and proliferation. ETV6 participates in the Ras-MAPK pathway which influences cell growth by regulating transcription of genes essential for these processes. It also interacts closely with proteins like ABL1 in this pathway modulating both kinase activity and gene control highlighting the critical connections it maintains in cell signaling networks.

ETV6 exhibits pivotal roles in oncogenic processes such as those observed in leukemia. Its involvement in translocation events like the ETV6-RUNX1 fusion contributes to the pathogenesis of acute lymphoblastic leukemia (ALL) by altering normal gene regulation. Additionally mutations within ETV6 link it to myelodysplastic syndromes with associated proteins in these disorders including FLT3. This connection highlights the pathogenic impact ETV6 permutations can have within hematological malignancies.
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製品プロトコール

For this product, it's our understanding that no specific protocols are required. You can visit:
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ターゲットの情報

Transcriptional repressor; binds to the DNA sequence 5'-CCGGAAGT-3'. Plays a role in hematopoiesis and malignant transformation.
See full target information ETV6
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文献 (1)

Recent publications for all applications. Explore the full list and refine your search

Nucleic acids research 44:10644-10661 PubMed27604872

2016

A quantitative proteomics approach identifies ETV6 and IKZF1 as new regulators of an ERG-driven transcriptional network.

Applications

Unspecified application

Species

Unspecified reactive species

Ashwin Unnikrishnan,Yi F Guan,Yizhou Huang,Dominik Beck,Julie A I Thoms,Sofie Peirs,Kathy Knezevic,Shiyong Ma,Inge V de Walle,Ineke de Jong,Zara Ali,Ling Zhong,Mark J Raftery,Tom Taghon,Jonas Larsson,Karen L MacKenzie,Pieter Van Vlierberghe,Jason W H Wong,John E Pimanda
View all publications
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Abcam product promise

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